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Method for near-infrared online monitoring content change of total flavonol glycosides in folium ginkgo extraction process

A total flavonol glycosides and extraction process technology, applied in the field of separation and purification of traditional Chinese medicine, can solve the problems of reagent consumption, information feedback lag, and inability to meet instant analysis, etc., to improve calculation speed, avoid redundant information and interference information, and be more practical value effect

Inactive Publication Date: 2015-04-22
NINGBO LIWAH PLANT EXTRACTION TECH
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Problems solved by technology

Traditional analysis methods, such as high performance liquid chromatography, ultraviolet spectrophotometry, etc., often require complex pretreatment of the samples taken, consume a lot of reagents, and information feedback lags behind, which cannot meet the needs of instant analysis in the production process

Method used

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  • Method for near-infrared online monitoring content change of total flavonol glycosides in folium ginkgo extraction process
  • Method for near-infrared online monitoring content change of total flavonol glycosides in folium ginkgo extraction process
  • Method for near-infrared online monitoring content change of total flavonol glycosides in folium ginkgo extraction process

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Embodiment 1

[0037] 1. Collection of calibration set samples

[0038] Twelve batches of different batches of Ginkgo extract, middle part of Ginkgo column solution, back part of Ginkgo column solution and Ginkgo analysis solution were collected. A total of 48 batches of extraction process liquid samples were used as calibration sets for near-infrared modeling.

[0039] Note: However, the middle part of the Ginkgo biloba column liquid and the back part of the Ginkgo biloba column liquid were tested by liquid phase, and quercetin, kaempferol and isorhamnetin were not detected, so it is really used for the correction of near-infrared modeling of Ginkgo biloba extract The set contains 12 batches of Ginkgo Extract and 12 batches of Ginkgo Analysis.

[0040] 2. Collection of near-infrared transmission spectra of samples

[0041] Instrument: MPA Fourier transform near-infrared spectrometer (Germany BRUKER company), the sample measuring device is a transmission sample cavity or transmission fiber ...

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Abstract

The invention discloses a method for near-infrared online monitoring content change of total flavonol glycosides in a folium ginkgo extraction process. The method comprises the following steps: associating data of a quercetin content, a kaempferide content and an isorhamnetin content measured by high performance liquid chromatography with near infrared spectral information by using a partial least squares method, and establishing a multivariate quantitative calibration model of the quercetin content, the kaempferide content and the isorhamnetin content in the folium ginkgo extraction process; quickly detecting the quercetin content, the kaempferide content and the isorhamnetin content in the unknown folium ginkgo extraction process by using the established multivariate quantitative calibration model. The method disclosed by the invention can be used for sampling an extracting solution in the folium ginkgo extraction process in real time and monitoring the content change of total flavonol glycosides in the folium ginkgo extracting solution in real time; the result is accurate and reliable.

Description

technical field [0001] The invention belongs to the technical field of separation and purification of traditional Chinese medicines, and in particular relates to a method for online near-infrared monitoring of the content change of total flavonol glycosides in the extraction process of ginkgo leaves. Background technique [0002] In the pharmaceutical process of traditional Chinese medicine, the extraction process, as one of the characteristic links in the production of traditional Chinese medicine, determines the proportion of different components in the finished product in traditional Chinese medicine, that is, determines the curative effect of the medicine. At present, the quality control of the extraction process of traditional Chinese medicine in my country is still very passive. Only the quality inspection of the end product is carried out, and the composition changes in the process are rarely considered. It is difficult to accurately control the production process, res...

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Application Information

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IPC IPC(8): G01N21/3577G01N21/359
Inventor 孙振蛟饶毅汪俊斯聪聪胡晓雁曾小飞
Owner NINGBO LIWAH PLANT EXTRACTION TECH
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