Recombinant human brain natriuretic peptide injection and preparation method thereof

A technology for human brain natriuretic peptides and injections, which is applied in pharmaceutical formulations, drug combinations, peptide/protein components, etc. It can solve the problems of high requirements for product dosage accuracy, cumbersomeness, secondary pollution, etc., and achieve good stability Sex and activity, easy to use, accurate effect of medication
CN104546702AInactive Publication Date: 2015-04-29SHIJIAZHUANG WOTAI BIOTECH
2 Cites 6 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHIJIAZHUANG WOTAI BIOTECH
Publication Date
2015-04-29
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a formula of a human brain natriuretic peptide liquid preparation which comprises human brain natriuretic peptide 0.5 mg / ml, a buffer solution system, polysaccharide alcohol, amino acid and a salt compound. The invention further discloses a preparation method of the human brain natriuretic peptide liquid preparation. Through selecting auxiliary materials, the recombinant human brain natriuretic peptide liquid preparation has favorable stability and activity so that the safety and effectiveness of medication are ensured.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of biomedical engineering, and in particular relates to a prescription of a recombinant human brain natriuretic peptide injection preparation and a preparation method thereof. Background technique

[0002] Protein instability mainly includes chemical instability and physical instability. Chemical instability leads to protein modification through bond formation or breakage, mainly including deamidation, racemization, hydrolysis, oxidation, β-elimination and binary Sulfur bond breaking or exchange, etc. Physical instability will not lead to covalent changes in proteins, but changes in higher-order structures (secondary structures and above) of proteins, mainly including denaturation, adsorption, aggregation, and precipitation. The purpose of research on the prescription of protein drug preparations is to stably prolong the storage time of protein drugs on the basis of maintaining the natural and pharmaceutical...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More