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Application of ilicin A to preparation of lipid-regulating drug preparation

A pharmaceutical preparation, the technology of Ilexin, applied in the field of medicine, can solve the problem that there is no research report on Ilexin A, etc.

Inactive Publication Date: 2015-04-29
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no research report on the lipid-lowering effect of hollyn A

Method used

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  • Application of ilicin A to preparation of lipid-regulating drug preparation
  • Application of ilicin A to preparation of lipid-regulating drug preparation
  • Application of ilicin A to preparation of lipid-regulating drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Preparation of granules Mix 200g hollyn A and 10g sweetener evenly, add binder 2% hydroxypropyl cellulose to dissolve, make soft material, pass through 20 mesh sieves, make granules. The obtained wet granules were dried in an oven at 80° C. for 2 hours, magnesium stearate was added to the granules, mixed evenly, and packed into bags.

Embodiment 2

[0017] Embodiment 2: the preparation of tablet 40g Ilexin A and 5g sweetener, 5g citric acid are mixed uniformly, add the ethanol of binder 50%, make soft material, cross 20 mesh sieves, make granule, the obtained wet The granules were dried in an oven at 70°C for 2 hours, magnesium stearate was added to the granules, mixed evenly, compressed into tablets and packaged separately.

Embodiment 3

[0018] Example 3: Preparation of Capsules 250g of Ilexin A and 2500g of starch were fully mixed with the dried starch and Ilexin A, passed through a 120 mesh sieve, and fully mixed to prepare 1000 capsules, each containing 250mg of Ilexin A.

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PUM

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Abstract

The invention discloses a novel medical application of a monomer component-ilicin A obtained from ilex hainanensis merr to the preparation of lipid-regulating drugs, and drug dosage forms such as granules and tablets prepared from the ilicin A as a raw material. In-vivo tests show that the ilicin A can remarkably improve blood lipid disorders of mice induced by high-lipid diets and reduce the serum apoprotein level of the mice within a certain dosage range. Therefore, the ilicin A can be used for preparing the lipid-regulating drugs and drugs for preventing and treating hyperlipemia.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the lipid-lowering activity of hollyn A and the new application of hollyn A in the preparation of lipid-lowering medicines. Background technique [0002] Ilexin A is a ursane-type triterpene derivative with a chemical structure such as figure 1 , with a higher content in Ilex plants, is the main characteristic component of camellia green tea (Johji Yamahara et al. Photochemistry, 1987, 26(7): 2023-2027). It has been reported that Ilexin A has a certain antibacterial effect (Xiao-Qing Chen et al. Food Chemistry, 2011.126(3):1454-1459). [0003] For example, patent document CN2012103974798 discloses a method for extracting hollyn A from camellia, and patent document CN103893188A discloses that hollyn A has potential development value in anti-tumor. [0004] At present, there is no research report on the lipid-lowering effect of hollylicin A. Contents of the invention [0005]...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P3/06
CPCA61K31/56A61K9/1652A61K9/2054A61K9/4866
Inventor 孙云赵珺娴沈彦君刘畅
Owner YANGZHOU UNIV
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