Preparation method of iodinated oil with stable quality

A technology of stable quality and iodized oil, which is applied in the fields of fat oil/fat refining, active ingredients of iodine compounds, and medical preparations containing active ingredients, etc., which can solve the problems of free iodine and easily exceeding the color and luster.

Active Publication Date: 2015-04-29
SHANGHAI WANXIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the most troublesome quality problem of iodized oil is that in the process of storage, transportation, sales, and waiting for use, free iodine and color are easily exceeded

Method used

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  • Preparation method of iodinated oil with stable quality

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 300g perilla seed oil is cooled to -10°C at a rate of 1-2°C per hour in a low-temperature thermostat (purchased from Kerui Instrument Co., Ltd., Gongyi City, model: Kerui brand DFY-50 / 30). degrees (about 20 hours), and continue to maintain at -10 degrees Celsius ± 0.5 degrees for 24 hours. In the Buchner suction funnel, take advantage of cold suction filtration to obtain 292g of defatted and dewaxed perilla seed oil.

[0039] In the hydrogen iodide gas generator (purchased from Dezhou Fukai Chemical Co., Ltd., model: 1000ml Qipu generator), add red phosphorus 15g, iodine sheet 200g, continuously and slowly drop hydriodic acid 70g, the generated The hydrogen iodide gas is absorbed into 292g of degreasing dewaxed perilla seed oil under stirring, to obtain 483g of iodized oil. The yield (according to the average iodine content of 40%) is 96.6%, the iodine content is 39.6%, the free iodine is qualified, and the color is qualified.

[0040] After the accelerated stability ...

Embodiment 2

[0048] With 300g walnut oil, in low-temperature thermostat (purchased from Kerui Instrument Co., Ltd., Gongyi City, model: Kerui brand DFY-50 / 30), drop the temperature by 1-2 degrees Celsius per hour to 5 degrees Celsius ( About 10 hours), continue to keep at 5 degrees Celsius ± 0.5 degrees for 24 hours. Take advantage of cold suction filtration in Buchner suction funnel to obtain 284g of degreasing and dewaxing walnut oil.

[0049] In the hydrogen iodide gas generator (purchased from Dezhou Fukai Chemical Co., Ltd., model: 1000ml Qipu generator), add red phosphorus 15g, iodine sheet 200g, continuously and slowly drop hydriodic acid 70g, the produced Hydrogen iodide gas is absorbed in the degreasing dewaxed walnut oil of 284g under stirring, obtains iodized oil 486g. The yield (according to the average iodine content of 40%) is 97.2%, the iodine content is 40.4%, the free iodine is qualified, and the color is qualified.

[0050] After the accelerated stability test at 54 deg...

Embodiment 3

[0055] With 300g grapeseed oil, in the low-temperature thermostat (purchased from Gongyi Kerui Instrument Co., Ltd., model: Kerui brand DFY-50 / 30), the temperature is lowered to -5°C at a rate of 1-2°C per hour. degrees (about 15 hours), and continue to maintain at -5 degrees Celsius ± 0.5 degrees for 24 hours. In the Buchner suction funnel, take advantage of cold suction filtration to obtain 287g of defatted and dewaxed grapeseed oil.

[0056] In the hydrogen iodide gas generator (purchased from Dezhou Fukai Chemical Co., Ltd., model: 1000ml Qipu generator), add red phosphorus 15g, iodine sheet 200g, continuously and slowly drop hydriodic acid 70g, the generated The hydrogen iodide gas is absorbed in the defatted dewaxed grapeseed oil of 287g under stirring, obtains 485g of iodized oil. The yield (according to the average iodine content of 40%) is 97.0%, the iodine content is 39.7%, the free iodine is qualified, and the color is qualified.

[0057] After the accelerated sta...

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Abstract

The invention relates to a preparation method of iodinated oil with stable quality and belongs to the technical field of organic synthesis. The preparation method is characterized in that vegetable oil is frozen at -10-10 DEG C to remove low-iodine substances such as wax and saturated fat before the vegetable oil and hydrogen iodide gas carry out additive reaction. The special treatment aims at removing the low-iodine substances such as the wax and the saturated fat to facilitate an increase in an iodine value of the oil, further improving bound firmness of the iodinated oil to bound iodine (improving stability of organic iodine), and reducing precipitation and color deepening of free iodine.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a method for preparing iodized oil with stable quality. Background technique [0002] According to the definition of Chinese Pharmacopoeia 2005 edition, iodized oil is iodized vegetable oil containing 37-41% iodine. It is mainly used in the treatment of iodine deficiency symptoms, radiodiagnostic contrast agent (contrast agent) and adjuvant therapy of tumors. [0003] The current iodized oil process is to directly add the vegetable oil and hydrogen iodide gas, then remove the colloid through the water washing process, convert the unstable iodine into free iodine through the aeration process, and then add sodium metabisulfite Remove free iodine. [0004] At present, the most troublesome quality problem of iodized oil is that in the process of storage, transportation, sale, and waiting for use, free iodine and color are easily exceeded. [0005] This field ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11C3/00C11B3/00A61K33/18A61K36/87A61K36/66A61K36/55A61K36/535A61K36/52A61K36/286A61K36/282A61P3/02A61P35/00A61K49/04
CPCC11B3/00C11C3/00
Inventor 袁相富张崇东赵铭
Owner SHANGHAI WANXIANG PHARMA
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