Design of fast capacitance compensation circuit
A technology of capacitance compensation and capacitance, which is applied in the field of biomedicine to achieve the effects of easy adjustment, accurate and fast compensation, and small design volume
Inactive Publication Date: 2015-04-29
TIANJIN POLYTECHNIC UNIV
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Problems solved by technology
[0006] The purpose of the present invention is to provide a fast capacitance compensation circuit, which aims to solve the fast capacitance interference generated in the measurement process of nanopore nucleic acid sequencing technology and patch clamp technology, and aim at the time delay component and timeless component in fast capacitance interference. Fast Capacitor Compensation Circuit for Compensating Delay Components Separately
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[0019] A design of a fast capacitor compensation circuit, including compensation channel 1 and compensation channel 2 connected by an adder with a gain of 1, respectively realizing the compensation of the component without time delay and the component with time delay in the fast capacitor interference, compensation channel 1 and Compensation channel 2 is connected through an adder with a gain of 1 and injected into the capacitor to obtain the final fast capacitor compensation current. The present invention will be described in detail below in conjunction with the accompanying drawings.
[0020] Such as figure 1 As shown, the system is mainly composed of four parts: compensation channel 1, compensation channel 2, adder and injection capacitor. where compensation channel 1 as figure 2 As shown, it is composed of a gain programmable amplifier 1, and its purpose is to realize the adjustment of the amplification factor of the compensation channel 1. Through the selection of diff...
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The invention is applicable to the field of biomedicine and provides a design method of a fast capacitance compensation circuit. The fast capacitance compensation circuit comprises a compensation channel 1 and a compensation channel 2, the compensation channel 1 is used for compensation of non-time-delay components in fast capacitance interference, and the compensation channel 2 is used for compensation of time-delay components in fast capacitance interference. The compensation channel 1 is formed by a programmable-gain amplifier 1, and compensation of different non-time-delay components in fast capacitance interference can be realized by adjusting amplification factors of the programmable-gain amplifier 1. The compensation channel 2 is formed by a resistor, a programmable-gain amplifier 2 and a programmable capacitor, and compensation of different time-delay components in fast capacitance interference can be realized by adjusting capacitance of the programmable capacitor and amplification factors of the programmable-gain amplifier 2. Outputs of the compensation channel 1 and the compensation channel 2 pass through a summator with a gain being 1 to obtain a final fast capacitance compensation output, and final fast capacitance compensation current can be obtained by the aid of an injection capacitor 8.
Description
technical field [0001] The invention belongs to the field of biomedicine, in particular, a fast capacitance compensation circuit is designed. Background technique [0002] As the third-generation gene sequencing technology, nanopore nucleic acid sequencing technology overcomes the shortcomings of existing nucleic acid sequencing technology such as long measurement time, high price, and complicated sequencing process. It is a gene sequencing technology with fast reading speed, low cost and simple operation. . The basic principle is to distinguish different DNA bases by measuring the current change caused by single-stranded DNA passing through a nanopore with a bias voltage, and then complete the sequencing. When the DNA is in contact with the nanopore, the measured current will appear a capacitive-dominated, extremely short-duration spike interference signal. The interference source causing this signal is generally called a fast capacitor, and its main source is the nanopore...
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Inventor熊慧董锟刘近贞
OwnerTIANJIN POLYTECHNIC UNIV