Detection reagents for fast and real-time dynamic monitoring and multimode imaging in early stage of cardio-cerebrovascular related diseases

A multi-modal imaging, cardiovascular and cerebrovascular technology, applied in MRI/MRI contrast agents, preparations for in vivo experiments, emulsion delivery, etc., to achieve precise and effective treatment, achieve precise marking, and avoid biological toxicity. Effect

Active Publication Date: 2015-05-06
SOUTHEAST UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, these methods have certain limitations, and it is particularly important to find a sensitive and specific minimally invasive detection technology for the early diagnosis of cardiovascu

Method used

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  • Detection reagents for fast and real-time dynamic monitoring and multimode imaging in early stage of cardio-cerebrovascular related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Detection reagents for metal ions and their nanoclusters and porphyrin derivatives for early, rapid, real-time, and multimodal detection of stroke

[0026] Firstly, the metal ion and its nano-cluster and porphyrin derivative reagent with excellent biocompatibility are prepared. 0.1~100mmol / L. The metal ion is one or a mixture of any two of gold ions, silver ions, platinum ions, zinc ions, etc. The nano-cluster is one of gold nano-cluster, silver nano-cluster, platinum nano-cluster or a mixture of any two; the porphyrin is a sulfonic porphyrin derivative.

[0027] When the reagent is used for stroke imaging, the metal ion and its nanocluster reagent and porphyrin derivative reagent are injected into the normal control model mice and stroke model mice induced by vascular injury through tail vein injection or local injection, and the metal ion And its nano-clusters and porphyrin derivative reagents can be quickly enriched in brain ischemia and hypoxia and oth...

Embodiment 2

[0033] Example 2 Metal ions and their nano-clusters and porphyrin derivative reagents applied to the early, rapid, real-time, and multimodal detection of atherosclerosis.

[0034] When the reagent is used for atherosclerosis imaging, reagent solutions such as metal ions and their nanocluster reagents and porphyrin derivatives are injected into normal control model mice and atherosclerosis model mice through tail vein injection or local injection. Metal ions and their nano-clusters and porphyrin derivative reagents can be quickly enriched in the lesions in blood vessels, and the model mice are imaged using small animal in vivo fluorescence imagers, CT, ultrasound, and MRI imaging instruments. Relevant specific steps include:

[0035] 1) Construct animal models such as atherosclerosis model mice;

[0036] 2) Inject 0.3 mL of sterile reagent solutions of metal ions and their nano-clusters and porphyrin derivatives with a concentration of 50 mmol / L into animal models such as norm...

Embodiment 3

[0042] Same as Example 2, except that the metal ion platinum ion of 100 mmol / L is the metal ion platinum ion that the difference is the 0.1mL sterile concentration that adopts; The nano-cluster is a silver nano-cluster; The porphyrin derivative is a sulfonic acid porphyrin derivative. The result is the same as in Example 2.

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Abstract

The invention discloses detection reagents for fast and real-time dynamic monitoring and multimode imaging in the early stage of cardio-cerebrovascular related diseases. The reagents consist of transition metal ions and precious metal ions with good biocompatibility and nano-cluster and porphyrin derivatives thereof; non-intrusive real-time dynamic high-sensitivity fast tracing and monitoring of cardio-cerebrovascular related diseases are realized through accurate targeted fast labeling and imaging of related focus parts; the detection reagents can be applied to accurate detection, imaging and real-time dynamic monitoring of the focus parts of the diseases such as stroke, atherosclerosis, myocardial infarction, cerebral ischemia and cardiac ischemia as well as reperfusion injury thereof; the treatment can be guided by use of related focus images without causing any biological toxic or side effects; and the detection method is simple and easy to implement.

Description

technical field [0001] The invention belongs to the technical field of cardiovascular and cerebrovascular, and in particular relates to a detection reagent applied to early, fast, real-time dynamic monitoring and multimodal imaging of cardiovascular and cerebrovascular related diseases. Background technique [0002] Cardiovascular and cerebrovascular diseases are diseases involving the circulatory system. The circulatory system refers to the organs and tissues that transport blood in the human body, mainly including the heart, blood vessels (arteries, veins, microvessels), etc., which can be subdivided into acute and chronic. related to hardening. These diseases all have similar etiology, pathogenesis and treatment methods. However, so far, there is still no particularly effective method for the treatment of cardiovascular and related diseases. Therefore, early diagnosis has become an important way to improve the survival rate of patients with cardiovascular and cerebrovas...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/08A61K49/18
Inventor 王雪梅来兰梅赵春秋
Owner SOUTHEAST UNIV
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