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Detection reagents for early, rapid, real-time dynamic monitoring and multimodal imaging of cardiovascular and cerebrovascular diseases

A multi-modal imaging, cardiovascular and cerebrovascular technology, applied in the direction of MRI/MRI contrast agents, preparations for in vivo tests, emulsion delivery, etc., to achieve simple and easy detection methods, avoid biological toxicity, and achieve accurate mark effect

Active Publication Date: 2017-11-28
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods have certain limitations, and it is particularly important to find a sensitive and specific minimally invasive detection technology for the early diagnosis of cardiovascular and related diseases
So far, there are still no reports on reagents capable of early, rapid, real-time, multimodal imaging of cardiovascular and cerebrovascular diseases and related diseases

Method used

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  • Detection reagents for early, rapid, real-time dynamic monitoring and multimodal imaging of cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Detection reagents for metal ions and their nanoclusters and porphyrin derivatives applied to early, rapid, real-time, multimodal detection of stroke

[0026] Firstly, the metal ion and its nano-cluster and porphyrin derivative reagent with excellent biocompatibility are prepared. 0.1~100mmol / L. The metal ion is one or a mixture of any two of gold ions, silver ions, platinum ions, zinc ions, etc. The nano-cluster is one of gold nano-cluster, silver nano-cluster, platinum nano-cluster or a mixture of any two; the porphyrin is a sulfonic porphyrin derivative.

[0027] When the reagent is used for stroke imaging, the metal ion and its nanocluster reagent and porphyrin derivative reagent are injected into the normal control model mice and stroke model mice induced by vascular injury through tail vein injection or local injection, and the metal ion And its nano-clusters and porphyrin derivative reagents can be quickly enriched in brain ischemia and hypoxia and ot...

Embodiment 2

[0033] Example 2 Metal ions and their nano-clusters and porphyrin derivative reagents applied to the early, rapid, real-time, and multimodal detection of atherosclerosis.

[0034] When the reagent is used for atherosclerosis imaging, reagent solutions such as metal ions and their nanocluster reagents and porphyrin derivatives are injected into normal control model mice and atherosclerosis model mice through tail vein injection or local injection. Metal ions and their nano-clusters and porphyrin derivative reagents can be quickly enriched in the lesions in blood vessels, and the model mice are imaged using small animal in vivo fluorescence imagers, CT, ultrasound, and MRI imaging instruments. Relevant specific steps include:

[0035] 1) Construct animal models such as atherosclerosis model mice;

[0036] 2) Inject 0.3 mL of sterile reagent solutions of metal ions and their nano-clusters and porphyrin derivatives with a concentration of 50 mmol / L into animal models such as norm...

Embodiment 3

[0042] Same as Example 2, except that the metal ion platinum ion of 100 mmol / L is the metal ion platinum ion that the difference is the 0.1mL sterile concentration that adopts; The nano-cluster is a silver nano-cluster; The porphyrin derivative is a sulfonic acid porphyrin derivative. The result is the same as in Example 2.

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Abstract

The invention discloses detection reagents for early, fast, real-time dynamic monitoring and multimodal imaging of cardiovascular and cerebrovascular related diseases. , through accurate targeted rapid labeling and imaging of relevant lesions, the non-invasive real-time dynamic high-sensitivity rapid tracking and monitoring of cardiovascular and cerebrovascular diseases can be applied to stroke, atherosclerosis, myocardial infarction, cerebral infarction, etc. Accurate detection, imaging, and real-time dynamic monitoring of lesion sites in diseases such as blood and cardiac ischemia and reperfusion injury, and can use related lesion images to guide treatment. There is no biological toxicity and side effects, and the detection method is simple and easy.

Description

technical field [0001] The invention belongs to the technical field of cardiovascular and cerebrovascular, and in particular relates to a detection reagent applied to early, fast, real-time dynamic monitoring and multimodal imaging of cardiovascular and cerebrovascular related diseases. Background technique [0002] Cardiovascular and cerebrovascular diseases are diseases involving the circulatory system. The circulatory system refers to the organs and tissues that transport blood in the human body, mainly including the heart, blood vessels (arteries, veins, microvessels), etc., which can be subdivided into acute and chronic. related to hardening. These diseases all have similar etiology, pathogenesis and treatment methods. However, so far, there is still no particularly effective method for the treatment of cardiovascular and related diseases. Therefore, early diagnosis has become an important way to improve the survival rate of patients with cardiovascular and cerebrovas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K49/08A61K49/18
Inventor 王雪梅来兰梅赵春秋
Owner SOUTHEAST UNIV
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