Hydrogel containing cyclodextrin and polyethylene glycol block polypeptide molecular brush as well as preparation method and application of hydrogel

Abstract

The invention discloses a polyethylene glycol block polypeptide molecular brush. The polyethylene glycol block polypeptide molecular brush has a structure as shown in a formula (1) in the specification, and comprises a main chain and a side chain, wherein the main chain is a two-block polymer composed of polyethylene glycol and polypeptide; the side chain is an alkoxy ether dendrimer. The preparation method comprises the following steps: preparing gamma-chloroethyl-L-glutamate from chlorohydrin and L-glutamic acid, and initiating the ring opening polymerization of alpha-amino acid-N-carboxyanhydride by use of amino polyethylene glycol monomethyl ether to obtain polyethylene glycol-b-poly(gamma-chloroethyl-L-glutamate; grafting the alkoxy ether dendrimer to the polypeptide chain by virtue of azidation and click reaction, thereby preparing the polyethylene glycol block polypeptide molecular brush. The invention also discloses a hydrogel containing alpha-cyclodextrin and the polyethylene glycol block polypeptide molecular brush. The hydrogel is prepared by mixing and stirring the molecular brush and the alpha-cyclodextrin in water and then performing ultrasonic and standing treatment. The hydrogel has unique structure andmorphology and excellent biocompatibility, and has wide application prospect in the fields of functional materials, cell culture medias, medicine carrier and the like.

Description

technical field [0001] The invention belongs to the technical field of new materials, specifically relates to a polymer material technology, and more specifically relates to a molecular brush hydrogel containing cyclodextrin and polyethylene glycol block polypeptides and its preparation method and application. Background technique [0002] Due to the similarity of the polymer hydrogel system in simulating the softness and network structure of the extracellular matrix and the response performance of multiple external stimuli, more and more scientists have paid more and more attention to it and studied it extensively. The gel system is used in drug loading, tissue engineering and other fields. Polypeptide has a structure similar to that of biological proteins, and due to the action of hydrogen bonds, it can form a unique ordered secondary conformation (α-helix, β-sheet, etc.) structure, which distinguishes it from traditional polymers. , the hydrogel system constructed by it ...

AI Technical Summary

Problems solved by technology

[0004] However, there is no report in the prior art on the construction of supramolecular gel systems based on the co-action of polypeptide copolymer molecular brushes with dendritic molecular structures and cyclodextrins

Images