Unlock instant, AI-driven research and patent intelligence for your innovation.

Cancer treatment

A compound and selected technology, applied in the field of cancer treatment, can solve the problems of infection and patient pain in multiple puncture sites, and achieve the effect of significant cost-effectiveness and improved quality of life

Inactive Publication Date: 2015-05-06
MOREX DEV PARTNERS
View PDF4 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Invasive nature of drug delivery creates risk of infection at multiple puncture sites
[0004] Most importantly, administration of radiosensitizers is painful for patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cancer treatment
  • Cancer treatment
  • Cancer treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Formulations containing compounds of the invention were made with the following components and are listed in Table 1 below:

[0111] Table 1

[0112]

[0113]

Embodiment 2

[0115] animal tumor model

[0116] SCCVII murine squamous cell carcinoma cells were cultured in D-MEM containing 10% fetal bovine serum, 1% penicillin / streptomycin and 1% L-glutamine. Only 1-3 passages were used to induce tumors. Then, the cells (2×10 5 each, 0.05 ml medium) were subcutaneously transplanted into the left thigh of 20-25 g female C3H mice (Charles River Laboratories, Wilmington, MA).

[0117] 9% CRM preparation

[0118] MTL005 (lot CS08-119A, 98% pure by % area analysis) supplied by Cambridge Major Laboratory was used to prepare three 15 mL batches of the ~3 mg / mL formulation (MX4-33). The final concentration by HPLC analysis was 2.80 mg / mL copper meso-5,15-bis[3-[(1,2-dicarbo-closed-dodecaboryl)methoxy]phenyl]-meso- 10,20-Dinitroporphyrin (MTL005), with a purity of 97% by HPLC analysis.

[0119] Boron and MTL005 Analysis

[0120] Direct current plasma atomic emission spectrometry [DCP-AES] (ARL / Fisons Model SS-7) was used to determine (limit of detection:...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A carborane-comprising porphyrin of Formula (1) is provided for use in cancer therapy that extends the period of time between the doses required while the patient is undergoing radiation therapy. The compound can be given not more often than once every 2 or more weeks, avoiding repeated administration, while radiation therapy can continue regularly.

Description

technical field [0001] The present invention relates to cancer treatment using radiation therapy. Background technique [0002] Cancer can be treated in many ways. One of these is radiation therapy with a radiosensitizer. This two-pronged approach increases the likelihood of successful cancer treatment. Radiosensitizers are compounds that, when administered to a patient, make tumors more sensitive to radiation therapy, or act as oxygen mimics, thereby increasing the free radicals available to ionizing radiation. The latter type of compound causes repair mechanisms in cells to overwhelm and cell death to occur. [0003] It is time-consuming for professionals to administer radiosensitizers, and medical institutions charge a lot for treatments involving radiosensitizers. Typically, radiosensitizers are administered intravenously or by injection, usually in large volumes of fluid, which require a significant amount of time to administer, and a single dose may take more than ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K51/04A61P35/00C07D487/22
CPCA61K31/555A61K31/69A61K41/0038A61K41/0057A61K41/0095A61K51/0485A61N2005/1098A61P35/00C07D487/22A61K41/0076A61K31/409A61K33/34A61N5/10
Inventor C·贝蒂A·沃兹沃思J·伦尼
Owner MOREX DEV PARTNERS
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com