Compound vitamin oral solution composition and preparation method thereof

A technology for compound vitamin and oral solution, which is applied to the formulation of compound vitamin oral solution and the field of preparation thereof, can solve the problems of unfavorable intensive breeding of livestock and poultry, difficult vitamin content, large addition amount and the like, and achieves beneficial egg production performance. , the preparation process is simple, the production cost is low

Inactive Publication Date: 2015-07-01
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product particles in vitamin products in the form of fine powder are not as small as possible. If the feed particles are large, the extremely small particles in the vitamin powder will sink to the bottom due to mixing and stirring. If the feed particles are small, the larger particles in the vitamin powder will The same is true for particles, resulting in uneven concentrations
[0005] (2) In order to prevent the vitamins from being damaged by the antioxidants in the feed after they are mixed with the feed, the fat-soluble vitamins in the vitamin premix are generally treated by the coating process. In contrast, its absorption and release pathways will change, and the absorption time will be prolonged, etc.
[0007] (4) It is difficult to determine the content of vitamins in finished feed additives, and there are many influencing factors, resulting in large errors in detection data and high detection costs
[0010] Most of the compound vitamin preparations in the existing patented technology are powders, tablets, and capsules, which are not conducive to intensive breeding of livestock and poultry, and are inconvenient to use
[0011] The dosage form of "a multivitamin for laying hens (CN102038111B; publication date: 2013.04.24)" is powder. The dosage form of this prescription is powder. The size of the feed particles affects the clinical use, resulting in uneven feed mixing and affecting individual absorption. , and is affected by the ambient temperature, because the fat-soluble vitamins in the formula are coated, so the release in the body is slow and the absorption route changes
[0012] "A multivitamin aqueous solution preparation (CN101564384B; publication date: 2012.03.07), the preparation form of this patent is an aqueous solution, the vitamin content in the formula is low, and the amount added in clinical use is large. Under the trend of large-scale breeding, it is difficult for transportation and inconvenience

Method used

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  • Compound vitamin oral solution composition and preparation method thereof
  • Compound vitamin oral solution composition and preparation method thereof
  • Compound vitamin oral solution composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]

[0036]

[0037] Preparation method:

[0038] (1) Heat polyoxyethylene 35 hydrogenated castor oil and maintain it at 60°C, add 2,6-di-tert-butyl-p-cresol, and keep stirring until the two are completely fused, and the solution is transparent and clear, and liquid A is obtained.

[0039] (2) Add vitamin A oil and vitamin D to liquid A at 60°C while stirring continuously 3 oil, vitamin E oil, stir evenly and fully dissolve to obtain liquid B;

[0040] (3) Mix propylene glycol and water for injection, heat to 60°C, stir and add vitamin B in turn 1 , Vitamin B 2 , Vitamin B 6 , pantothenic acid, folic acid, niacinamide, and vitamin C were stirred evenly and fully dissolved to obtain liquid C;

[0041] (4) Slowly add liquid C to liquid B at the same temperature, stir evenly, cool to room temperature, filter, and pack.

Embodiment 2

[0043]

[0044] Preparation method:

[0045] (1) Heat polyoxyethylene 40 castor oil and maintain it at 60°C, add 2,6-di-tert-butyl-p-cresol + tert-butylhydroxyanisole in sequence, and keep stirring until the two are completely fused and the solution becomes transparent Clarify to get liquid A.

[0046] (2) Cool liquid A to room temperature, add vitamin A oil and vitamin D under constant stirring 3 oil, vitamin E oil, stir evenly and fully dissolve to obtain liquid B;

[0047] (3) Mix propylene glycol and water for injection evenly, and add vitamin B successively under continuous stirring 6 , Vitamin B 12 , pantothenic acid, niacinamide, folic acid, biotin, β-carotene, stirred evenly and fully dissolved to obtain liquid C;

[0048] (4) Slowly add liquid C to liquid B, stir evenly, filter, and pack.

Embodiment 3

[0050]

[0051]

[0052] Preparation method:

[0053] (1) Heat polyoxyethylene 35 hydrogenated castor oil and maintain it at 60°C, add 2,6-di-tert-butyl-p-cresol, and keep stirring until the two are completely fused, and the solution is transparent and clear, and liquid A is obtained.

[0054] (2) Add vitamin A oil and vitamin D to solution A at 60°C under constant stirring. 3 oil, vitamin E oil, stir evenly and fully dissolve to obtain liquid B;

[0055](3) Mix propylene glycol and water for injection evenly, heat to 60°C, and add vitamin B sequentially under constant stirring 1 , Vitamin B 2 , Vitamin B 6 , Vitamin B 12 , Vitamin K 3 , vitamin C, pantothenic acid, nicotinamide, folic acid, biotin, β-carotene, stirred evenly and fully dissolved to obtain liquid C;

[0056] (4) Slowly add liquid C to liquid B at the same temperature, stir evenly, cool to room temperature, filter and bottle.

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Abstract

The invention relates to a compound vitamin oral solution composition and a preparation method thereof. The compound vitamin oral solution composition comprises a solubilizer, an antioxidant and a dispersion carrier, and is a liquid changing from bright yellow to orange red prepared through a special process. The compound vitamin oral solution composition disclosed by the invention has the advantages of simple preparation process, stable content, easy use and the like, and can be mutually soluble with water. Compared with powder vitamins, liquid vitamins are more convenient to use, manual mixing is not needed, mixing non-uniformity due to a particle size difference during a process of mixing with a feed is avoided, and use convenience is improved. The composition can be uniformly mixed with water in a random ratio.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a composition of a compound vitamin oral solution and a preparation method thereof. Background technique [0002] Vitamins, as the name suggests, are substances that maintain biological life, also known as vitamins. Vitamin is a very important ingredient in feed. Animals require very little of it, but it plays a great role in the body. If any one is lacking, it will cause disease. In recent years, the aquaculture industry has developed towards house feeding, cage breeding, and large-scale development. There is little or no green feed and high-quality grass powder, and vitamins cannot meet the needs. Moreover, livestock and poultry are intensively and professionally raised, and good breeds of livestock and poultry are used, which have high production performance and a large demand for vitamins. For this reason, vitamin additives are widely used. [0003] A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/593A61K31/714A61K9/08A61P3/02A61K31/355A61K31/07A61K31/525A61K31/519A61K31/51A61K31/455A61K31/4415A61K31/4188A61K31/375A61K31/197A61K31/015
Inventor 李梁孙俊刘拓
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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