33 results about "Vitamin products" patented technology

The invention belongs to the field of healthcare products and particularly relates to compound vitamin tablets and a preparation method thereof. Each compound vitamin tablet provided by the invention comprises a tablet core and a film coating layer, wherein the tablet core is mainly prepared from vitamin A acetate, sodium ascorbate, DL-alpha-tocopheryl acetate, nicotinamide, calcium pantothenate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, D-biotin, zinc oxide, sodium selenite, pre-gelatinized starch, maltodextrin, microcrystalline cellulose and silicon dioxide; and the film coating layer is mainly prepared from hydroxypropyl methyl cellulose, polyethylene glycol 4000, polyvinylpyrrolidone, titanium dioxide, castor oil and water. The compound vitamin tablets provided by the invention have the advantages of high safety and abundant nutrition and can provide the vitamins and minerals necessary for pregnant women so as to enhance immunity; meanwhile, the compound vitamin tablets can effectively reduce the abortion rate of pregnant women and oaf incidence; and therefore, the compound vitamin tablets are a perfect compound vitamin product for pregnant women.

The invention discloses a process for coating a multi-vitamin for a cow rumen. The process comprises the following specific steps of (1) weighing raw materials and mixing to obtain a first mixed raw material, adding carboxymethyl cellulose to the first mixed raw material for granulation to obtain a core material; and (2) adding a coating material to the core material and sampling the coating material through a peristaltic pump at a speed of 8-11 ml / min under the conditions that the atomization pressure is 1.2-1.8MPa, the air-induced frequency is 50HZ, the compressed air temperature is 52-60 DEG C, the air inlet temperature is 36-46 DEG C and the air outlet temperature is 22-25 DEG C to obtain a finished product. A compound polymer material sensitive to a pH value is a coating wall material, a bottom-spray fluidized bed coating process of coating after granulation is adopted and relatively ideal physical coating protection can be carried out on the multi-vitamin of a ruminant; and the ratio of the coating material and the core material is 6-8%, so that the rumen protection rate of a prepared multi-vitamin-coated product is greater than 70%, the release rate of a true stomach (abomasums) is greater than 60% and the economical benefit of a feeder can be improved.

The invention belongs to a nursing device and provides a suction type nursing rod combination and a suction type nursing set, so as to solve the problems that in the case of poor air quality or life and work in a special environment at present, adverse effects are likely to be caused to body health, and harm is caused to the body health when the user smokes the electronic cigarette product for a long time. The nursing rod combination comprises a carrier rod and a hollow outer rod body, wherein the carrier rod is placed in the outer rod body; one end of the outer rod body is provided with a suction nozzle and the other end is provided with an air hole; the suction nozzle and the air hole are communicated with the hollow part of the outer rod body; the carrier rod carries a suction type nursing material; the suction type nursing material is one or a combination of more than one of a traditional Chinese medicine extract, a plant extracting solution, a vitamin product and essential oil. The nursing set further comprises a packaging box or a packaging bag used for containing the suction type nursing rod combination. The number of the outer rod bodies is one or more, the number of the carrier rods is one or more, and the number of the containers is zero, one or more. When the number of the containers is more than one, the types of the suction type nursing materials are different.

The invention discloses a high performance liquid chromatographic analysis method for simultaneous determination of the content of 14 kinds of vitamins; octadecylsilane bonded silica gel is used as a filling agent, a 0.1 M sodium acetate solution-methanol is used as a mobile phase for gradient elution, gradient flow velocity of the mobile phase and a program change wavelength of an ultraviolet detector are combined, and intact separation and quantitative analysis of the 14 kinds of vitamins (including 4 kinds of fat soluble vitamins and 10 kinds of water soluble vitamins) can be achieved in 60 minutes. The method has the advantages of strong specificity, high precision, good stability, high accuracy, simple operation, and cheap and easily available reagents and consumable materials, is suitable for quality control of compound vitamin products in medicine and food industries, and can effectively save the cost and time of detection.

The invention discloses a method for removing mineral oil in natural vitamin E, which comprises the following steps: (1) sample loading: take a separating agent, add eluent a, fill it into a chromatographic column, wash it with eluent a Decompress the chromatography column, dissolve and load the sample according to raw material: eluent a (m / v) = 2: 1; (2) Elution: elute with the eluent a described earlier after loading the sample, and then Elute with eluent b; (3) Collection: collect the eluate in sections and concentrate to obtain natural vitamin E products; (4) Regeneration: wash and regenerate the chromatographic column with eluent c; the raw material is natural Vitamin E; the eluent a is a weak polar solvent; the eluent b is a mixed weak polar solvent composed of the eluent a and the eluent c; the eluent c It is a strong polar solvent. The invention well solves the problem of trace residue of mineral oil in natural vitamin E by utilizing the polarity difference between mineral oil and natural vitamin E.

The invention relates to a simple and convenient preparation method of a key intermediate (2-methyl-4-amino-5-amino methyl pyrimidine) for the vitamin B1. According to the method, lewis acid is used for catalyzing addition condensation reaction of acetamidine and 3-formyl amino ethyl cyanide and then catalyzing reaction of the condensation product and triethyl orthoformate to introduce a formyl chiral auxiliary, an imdo group and the formyl chiral auxiliary are subjected to ring formation to form 2- methyl-4-formyl amino-5- amino methyl pyrimidine, and finally basic hydrolysis is performed, so that 2-methyl-4-amino-5-amino methyl pyrimidine is obtained. The reaction procedures are carried out sequentially by adopting the one-pot method, the products in each step require no separation and purification, and the operation is simple and convenient. According to the method, highly toxic o-chloroaniline and other phenylamine compounds are not used, so that residue of o-chloroaniline compounds in the vitamin B1 product can be completely avoided. Meanwhile, the production wastewater is less and the yield is high.

The invention discloses a method for extracting vitamins from guavas. The method comprises the following steps of: (1) selecting the guavas, thoroughly cleaning the selected guavas, cutting the cleaned guavas in an extraction protective solvent, and removing seeds; (2) adding the flesh of the cut guavas and the extraction protective solvent in a vacuum pulping machine together, and pulping the guava flesh; (3) adding the pulp generated through pulping to a vacuum mixer to perform vacuum mixing; (4) filtering the materials obtained in the step (3) to obtain a filtrate, leaving the filtrate to stand for layering, and performing separation so as to obtain an organic phase; (5) adding water of which the pH is smaller than 7 to the organic phase obtained in the step (4), and performing vacuum mixing for 2 hours or more so as to obtain a solution; (6) leaving the solution to stand for layering, and performing separation so as to obtain an aqueous phase; and (7) performing vacuum concentration on the aqueous phase until the concentrated aqueous phase is dried, and performing freeze drying so as to obtain crude vitamin products. Through the adoption of the extraction method disclosed by the invention, the vitamins in the guavas can be extracted; the extraction method is simple, and is suitable for large-scale popularization and application; the content of the vitamins in extract is high.

The invention provides a method for refining thiothiamine and the resulting thiothiamine product and vitamin B1 product, and relates to the technical field of compound purification. The method firstly washes the crude product of thiothiamine with alcohol and water to obtain crude product A; then dissolves the crude product A in low-carbon alcohol to obtain solution A, and decolorizes to obtain solution B; then the thiothiamine is obtained from the solution Precipitate in B and dry to obtain refined thiothiamine. It is detected that the purity of the refined thiothiamine in the present invention can be significantly improved compared with the thiothiamine synthesized by the existing technology, which provides guarantee for the preparation of subsequent vitamin B1 products.

The invention provides a feed additive for improving the quality of the fur of a furry animal. The additive is obtained by mixing a semi-finished vitamin product, a semi-finished trace element product, dihydropyridine, methionine, cystine and corn gluten meal according to a weight ratio of 1:1:0.3-1:0.2-0.9:0.1-0.6:2, wherein the semi-finished vitamin product is prepared by uniformly mixing the following components: 5-22 parts of vitamin A, 3-8 parts of vitamin D, 10-25 parts of vitamin E, 3-8 parts of vitamin B1, 8-15 parts of biotin, 1-3 parts of vitamin B6, and 120-160 parts of the corn gluten meal, and the semi-finished trace element product is prepared by uniformly mixing the following components: 10-20 parts of methionine chelated zinc, 2-5 parts of methionine chelated copper, and 70-90 parts of zeolite powder. The additive of the invention allows the quality of the fur of the furry animals (martens, foxes and raccoon dogs) to be substantially improved, the hair density to be increased, the hair length to be improved, the hide toughness to be increased and the culture benefit to be improved.

The present invention relates to the technical field of vitamin K2 preparation, in particular to a calcium supplement composition containing vitamin K2 and its preparation method and application, comprising the following steps: (1) inoculating Flavobacterium into a culture medium for fermentation, and then fermenting Add a sedimentation accelerator to the liquid, and separate the bacterial cells after the bacterial cells in the fermentation liquid settle, and set aside. (2) Freeze-dry the bacteria and pulverize them into powder, then mix with acetone for extraction, take the extract after completion, and set aside. (3) adding clear water to the extract, and separating the precipitate after the precipitation of the precipitate is completed, to obtain the crude vitamin K2 product. (4) Mix the crude vitamin K2 product with acetone again for extraction, then add clear water, separate the precipitate after the precipitation of the precipitate is completed, and obtain the vitamin K2 product. The method of the invention can not only effectively extract the vitamin K2 in the flavobacterium, but also has the characteristics of convenient extraction and suitability for industrial application.

The invention relates to a method for removing zearalenone from natural vitamin E and a pure vitamin E product obtained by the method. The method for removing zearalenone comprises the steps of pretreatment with iminodiacetic acid type chelating resin, column packing, adsorption, washing, separation and the like. The process of the method for removing zearalenone in the present invention is simple, does not introduce other substances, does not require other separation steps, and does not cause secondary pollution to vitamin E products; compared with adsorbents such as diatomite montmorillonite, the adsorption The efficiency is about 80-90% high, and the material loss is small.

The invention relates to a method for removing natural vitamin E containing glycidyl ester, 3-chloropropanediol and esters thereof and a high-purity vitamin E product obtained by the method. The removal method comprises the steps of activated carbon acid treatment, activated carbon acylating chlorination, activated carbon amination, adsorption, separation and the like. The technical process is simple and easy to implement, no secondary pollution is caused to the natural vitamin E product, and compared with the used natural vitamin E raw material, the glycidyl ester content and the total content of 3-chloropropanediol and 3-chloropropanediol ester of the high-purity vitamin E product obtained through the method are reduced by 85% or above and 88% or above respectively.

The invention relates to a synthetic method of 2-methyl-4-amino-5-formyl aminomethylpyrimidine. The method comprises the following steps: a benzene solvent and a solid acid catalyst are added to a reaction flask and stirred, alpha-sodio formyl-beta-formyl aminopropionitrile is added, heating is performed, an acetamidine hydrochloride solution dissolved in an alcohol solvent is added dropwise, a thermal reaction and filtering are performed, the solid acid catalyst is recovered and treated for recycling, and a filtrate is a 2-methyl-4-amino-5-formyl aminomethylpyrimidine solution. O-chloroaniline as a raw material used in the traditional synthetic process is not used, 2-methyl-4-amino-5-formyl aminomethylpyrimidine is directly synthesized from alpha-sodio formyl-beta-formyl aminopropionitrile and acetamidine hydrochloride under the action of the solid acid catalyst, intermediate processes are omitted, the method is an environment-friendly process because the solid acid catalyst is recyclable, and trace cancerogen residues in a vitamin B1 product are avoided; synthesis yield is high, and the requirement for current green development is met.

The invention discloses a method for extracting natural vitamin C from capsicum granules. The method comprises the following steps: (1) degreasing: placing a proper amount of capsicum granules in a reaction tank, adding a degreasing solvent, carrying out stirring at a normal temperature, and carrying out filtering separation, so as to obtain degreased residues; (2) extracting: adding a vitamin C extracting solution into the degreased residues, carrying out vacuum stirring at a low temperature, and carrying out filtering separation, so as to collect filter liquor; (3) capsaicin removing: addingvegetable oil in the filter liquor, carrying out vacuum stirring at a normal temperature, and carrying out water-oil separating, so as to collect a vitamin C aqueous solution; and (4) drying: subjecting the vitamin C aqueous solution to vacuum depressurized concentration, and then, carrying out vacuum freeze drying, thereby obtaining the natural vitamin C. According to the method disclosed by theinvention, due to degreasing pretreatment, interference to detection on the vitamin C caused by lipids is avoided, and meanwhile, the rate of extraction can be increased; due to vacuum low-temperature extraction, the loss of the vitamin C is lowered to the maximum; due to capsaicin removing treatment, the purity of the vitamin C product is improved; and the method is simple in operation, easy toimplement and low in cost.

The invention discloses a method and a system for low-residual multi-stage stripping of a vitamin E by-product fatty acid solvent, and the method is as follows: distilling a deodorized distillate fromwhich sterol is removed to respectively obtain a distillate and a residual liquid; performing multi-stage stripping on the distillate, and evaporating a solvent to obtain a vitamin E product. The method has the advantages of extremely low residual capacity, low labor intensity, low environmental pollution, easy control of reaction, and high purity and high recovery rate of the vitamin E.