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Synthesis process of vitamin B5

A synthesis process and vitamin technology, applied in the field of vitamin B5 synthesis technology, can solve the problems of high pollution and high cost, and achieve the effects of protecting the environment, reducing direct emissions and rationalizing the synthesis process.

Inactive Publication Date: 2020-08-11
XIANTAO XIANSHENG FINE CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has disadvantages such as high cost and large pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A synthesis process of vitamin B5, comprising the following steps:

[0015] 1) Add 130 parts of glyoxylic acid and 3 parts of triethylamine into the reaction kettle, stir until the solution is yellow and transparent, then slowly add 50 parts of isobutyraldehyde dropwise, after the dropwise addition, raise the temperature to 60°C, react for 3 hours, and the reaction ends Finally, transfer the reaction materials directly to the high-pressure reaction kettle, add 200 parts of water, 0.1 part of catalyst, feed hydrogen, keep the pressure at 2-3Mpa, filter and remove the catalyst after the reaction is completed, recycle and reuse, and transfer the filtrate to the esterification kettle. Add sulfuric acid to the esterification kettle and heat up to 80°C for 3 hours. After the reaction, cool down to 45°C, extract with 100 parts of 1,2-dichloroethane, and neutralize the organic phase with 30 parts of 1% sodium carbonate aqueous solution to 6-7, separate the water layer for waste...

Embodiment 2

[0021] A synthesis process of vitamin B5, comprising the following steps:

[0022] 1) Add 140 parts of glyoxylic acid and 4 parts of triethylamine into the reaction kettle, stir until the solution is yellow, transparent and clear, then slowly add 55 parts of isobutyraldehyde dropwise, after the dropwise addition, raise the temperature to 60°C, react for 3 hours, and the reaction ends Finally, the reaction materials are directly transferred to the high-pressure reactor, and 220 parts of water and 0.2 parts of catalyst are added, and hydrogen gas is introduced to keep the pressure at 2-3Mpa. After the reaction is completed, the catalyst is filtered and removed for recycling, and the filtrate is transferred to the esterification kettle. Add sulfuric acid to the esterification kettle and raise the temperature to 80°C for 3 hours. After the reaction, cool down to 45°C, extract with 110 parts of 1,2-dichloroethane, and neutralize the organic phase with 32 parts of 1% sodium carbonate...

Embodiment 3

[0028] A synthesis process of vitamin B5, comprising the following steps:

[0029] 1) Add 145 parts of glyoxylic acid and 5 parts of triethylamine into the reaction kettle, stir until the solution is yellow, transparent and clear, start to slowly add 60 parts of isobutyraldehyde, after the dropwise addition, raise the temperature to 60°C, react for 3 hours, and the reaction ends Finally, transfer the reaction materials directly to the high-pressure reactor, add 250 parts of water, 0.3 parts of catalyst, feed hydrogen, keep the pressure at 2-3Mpa, filter and remove the catalyst after the reaction, recycle and reuse, and transfer the filtrate to the esterification kettle. Add sulfuric acid to the esterification kettle and heat up to 80°C for 3 hours. After the reaction, cool down to 45°C, extract with 120 parts of 1,2-dichloroethane, and neutralize the organic phase with 35 parts of 1% sodium carbonate aqueous solution to 6-7, separate the water layer for wastewater treatment, d...

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Abstract

The invention discloses a synthesis process of vitamin B5. The process comprises the following steps: adding glyoxylic acid and triethylamine into a reaction kettle; stirring until an obtained solution is yellow, transparent and clear; slowly dropwise adding isobutyraldehyde; extracting by using 1, 2-dichloroethane; removing a water layer for wastewater treatment; distilling to remove 1, 2-dichloroethane, continuously distilling to obtain a DL-pantolactone finished product, then splitting to obtain 99% d-pantolactone, mixing methanol, calcium oxide and alanine for calcium salt reaction, addingthe d-pantolactone for synthesis after the reaction is finished, and then crystallizing, drying and packaging to finally obtain a vitamin B5 product. The method is reasonable in synthesis process, low in cost and small in pollution, generated wastewater is neutralized through liquid caustic soda, an organic phase is neutralized through 10% sodium carbonate, direct emission of wastewater and wastegas is greatly reduced, and environment protection is facilitated.

Description

technical field [0001] The invention relates to the field of synthesis technology of additives, in particular to a synthesis technology of vitamin B5. Background technique [0002] Vitamin B5 is a vitamin drug and a component of coenzyme A. Among the helical calcium pantothenate, only the dextro-form has vitamin activity and participates in the metabolism of protein, fat and sugar in the body. For vitamin B deficiency and peripheral neuritis, as well as intestinal colic after surgery. Combined with vitamin C to treat disseminated lupus erythematosus. The lack of calcium pantothenate in the human body has the following symptoms: (1) growth arrest, weight loss, and sudden death. (2) Skin and hair disorders. (3) Nervous system disorder. (4) Digestive organ disorders, liver dysfunction. (5) Affect antibody formation. (6) Accessory kidney disorder. [0003] At present, the main method of synthesizing vitamin B5 is to mix D-pantoate lactone and 3-aminopropionate calcium in...

Claims

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Application Information

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IPC IPC(8): C07C231/02C07C231/20C07C231/24
CPCC07B2200/07C07C231/20C07C231/24C07D307/33C07C235/12
Inventor 邵新华徐亚华徐保华程永进
Owner XIANTAO XIANSHENG FINE CHEM
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