Cefpodoxime proxetil rapid-release preparation and preparation method thereof
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A cefpodoxime axetil and preparation technology, applied in the field of medicine, can solve the problems of cumbersome production process, high equipment requirements, and low dissolution rate of preparations, and achieve the effects of avoiding hydrogelation, improving dissolution rate, and ensuring stability
Active Publication Date: 2015-07-15
SHIJIAZHUANG NO 4 PHARMA
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[0016] The object of the present invention is to provide a kind of cefpodoxime axetil immediate-release solid preparation and preparation method thereof, to solve the problem that in the existing cefpodoxime axetil immediate-release solid preparation technology, the raw material is in a gel state when meeting water, and the dissolution rate of the preparation is low; Need special treatment and dry granulation requires high equipment requirements and cumbersome production process
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Embodiment 1
[0043] Embodiment 1 (1000 bag amounts)
[0044]
[0045] making process:
[0046] (1) Dissolve the prescribed amount of cefpodoxime axetil and polyoxyethylene hydrogenated castor oil in absolute ethanol to obtain mixture 1.
[0047] (2) Put anhydrous lactose, sucrose and carboxymethyl cellulose calcium in a fluidized bed and mix evenly, slowly spray into the mixture 1, granulate, and dry at 30°C in a fluidized bed to obtain the mixture 2.
[0048](3) Add xanthan gum, citric acid, talcum powder and orange essence to mixture 2, mix them all, and pack them separately.
Embodiment 2
[0049] Embodiment 2 (1000 bag amounts)
[0050]
[0051] making process:
[0052] (1) Dissolve the prescribed amount of cefpodoxime axetil and polyoxyethylene hydrogenated castor oil in absolute ethanol to obtain mixture 1.
[0053] (2) Put anhydrous lactose, sucrose and carboxymethyl cellulose calcium in a fluidized bed and mix evenly, slowly spray into the mixture 1, granulate, and dry at 30°C in a fluidized bed to obtain the mixture 2.
[0054] (3) Add xanthan gum, citric acid, talcum powder and orange essence to mixture 2, mix them all, and pack them separately.
Embodiment 3
[0055] Embodiment 3 (1000 bag amounts)
[0056]
[0057] making process:
[0058] (1) Dissolve the prescribed amount of cefpodoxime axetil and polyoxyethylene hydrogenated castor oil in absolute ethanol to obtain mixture 1.
[0059] (2) Put anhydrous lactose, sucrose and carboxymethyl cellulose calcium in a fluidized bed and mix evenly, slowly spray into the mixture 1, granulate, and dry at 30°C in a fluidized bed to obtain the mixture 2.
[0060] (3) Add xanthan gum, citric acid, talcum powder and orange essence to mixture 2, mix them all, and pack them separately.
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Abstract
The invention provides a cefpodoxime proxetil rapid-release solid preparation and a preparation method thereof. The cefpodoxime proxetil rapid-release solid preparation comprises cefpodoxime proxetil and a surfactant, wherein cefpodoxime proxetil accounts for 2.5-15wt% of the total preparation, and the surfactant accounts for 0.8-15.0wt% of the total preparation. The method for preparing the rapid-release solid preparation adopts wet granulation and specifically comprises the following steps: (1) dissolving cefpodoxime proxetil and the surfactant in absolute ethyl alcohol to obtain a mixture I; (2) after mixing a diluting agent with a disintegrating agent uniformly, slowly adding or spraying the mixture I and carrying out granulation and fluidized bed drying to obtain a mixture II; (3) adding a suspending aid, a flavoring agent and a lubricating agent to the mixture II and carrying out total mixing and subpackaging. The rapid-release solid preparation can be quickly dissolved out when meeting water and can not be gelated. Meanwhile, technology improvement is adopted, thus avoiding the processes of raw material grinding and micronization treatment; and special equipment, such as a dry type granulator, is unnecessary to be used, thus ensuring the product stability while simplifying the production operation.
Description
technical field [0001] The invention belongs to the technical field of medicines, in particular to a cefpodoxime axetil immediate-release solid preparation and a preparation method thereof. Background technique [0002] Cefpodoxime axetil chemical name: (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)-acetamido]-3-methanol Oxymethyl-8-oxo-5-thio-1-azabicyclo-[4,2,0]oct-2-ene-2-carboxylic acid isopropoxycarbonyloxyethyl ester, its structural formula is: [0003] [0004] Molecular formula: C 21 h 27 N 5 o 9 S 2 [0005] CAS: 87239-81-4 [0006] The trade name of cefpodoxime axetil is: VANTIN, which is the third-generation oral broad-spectrum cephalosporin developed in Japan. On August 7, 1992, cefpodoxime axetil tablet and dry suspension passed the FDA’s marketing application, and it was launched in the United States. listed. Cefpodoxime axetil is a third-generation cephalosporin with the advantages of broad antibacterial spectrum, long half-life, convenien...
Claims
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