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A kind of personalized customized porous tantalum implant and preparation method thereof

A technology of porous tantalum and implants, which is applied in the field of personalized customized porous tantalum implants and its preparation, which can solve the problems of poor fusion of new bone and scaffolds, difficult spherical holes, insufficient scaffold strength, etc., to achieve It is beneficial to the delivery of nutrients, promotes good fusion, and improves the mechanical properties

Active Publication Date: 2017-05-10
宁波创导三维医疗科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are two main methods for preparing porous tantalum. One is to carbonize organic foam at high temperature, and then use vapor deposition to deposit tantalum on the carbon support. This method is expensive, the support strength is insufficient, and the pores are non-spherical polygons. holes; the other is to use liquid materials as dispersants and pore-forming agents, and then dry and sinter them into porous tantalum. This method is not easy to obtain spherical holes suitable for cell growth, and the consistency of the holes is poor.
The pores of porous tantalum prepared by the two methods are easily blocked, resulting in poor fusion of new bone and scaffold

Method used

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  • A kind of personalized customized porous tantalum implant and preparation method thereof
  • A kind of personalized customized porous tantalum implant and preparation method thereof
  • A kind of personalized customized porous tantalum implant and preparation method thereof

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Effect test

Embodiment 1

[0043] Such as Figure 1 to Figure 6 As shown, a method for preparing a personalized porous tantalum implant of the present invention comprises the following steps:

[0044] 1) Use the CT multi-planar reconstruction image of bone tissue to reconstruct the three-dimensional model of bone tissue in three-dimensional modeling software (such as figure 1 shown), and then import the three-dimensional model of bone tissue into the reverse software to design a three-dimensional model of a personalized bone implant;

[0045] 2) Carry out shelling processing on the three-dimensional model of the personalized bone implant to obtain the shell 1 of the model after shelling, and then add criss-cross grids 3 inside the shell 1 of the shelled model to obtain a personalized model containing the grid 3 inside. The three-dimensional shell model of the bone implant, wherein the space 2 filled with the model slurry is between the criss-cross grids 3, the thickness h of the three-dimensional shell...

Embodiment 2

[0054] Such as Figure 1 to Figure 6 As shown, a method for preparing a personalized porous tantalum implant of the present invention comprises the following steps:

[0055] 1) Use the CT multi-planar reconstruction image of bone tissue to reconstruct the three-dimensional model of bone tissue in three-dimensional modeling software (such as figure 1 shown), and then import the three-dimensional model of bone tissue into the reverse software to design a three-dimensional model of a personalized bone implant;

[0056] 2) Carry out shelling processing on the three-dimensional model of the personalized bone implant to obtain the shell 1 of the model after shelling, and then add criss-cross grids 3 inside the shell 1 of the shelled model to obtain a personalized model containing the grid 3 inside. The three-dimensional shell model of the bone implant, wherein the space 2 filled with the model slurry is between the criss-cross grids 3, the thickness h of the three-dimensional shell...

Embodiment 3

[0065] Such as Figure 1 to Figure 6 As shown, a method for preparing a personalized porous tantalum implant of the present invention comprises the following steps:

[0066] 1) Use the CT multi-planar reconstruction image of bone tissue to reconstruct the three-dimensional model of bone tissue in three-dimensional modeling software (such as figure 1 shown), and then import the three-dimensional model of bone tissue into the reverse software to design a three-dimensional model of a personalized bone implant;

[0067] 2) Carry out shelling processing on the three-dimensional model of the personalized bone implant to obtain the shell 1 of the model after shelling, and then add criss-cross grids 3 inside the shell 1 of the shelled model to obtain a personalized model containing the grid 3 inside. The three-dimensional shell model of the bone implant, wherein the space 2 filled with the model slurry is between the criss-cross grids 3, the thickness h of the three-dimensional shell...

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Abstract

The invention discloses a customized porous tantalum implant and a preparation method thereof. The preparation method comprises the following steps: firstly, adopting CT or MRI scanning to obtain a multiplanar reconstruction image of a natural bone, designing the appearance of a customized implant, shelling the customized implant, and designing net racks in a shell; manufacturing prototypes of the thin shell and the net racks by a rapid prototyping machine; uniformly mixing tantalum powder and pellets capable of burning loss to obtain a mixture, adding the mixture in a dispersant to prepare mixed slurry of the powder and the pellets, filling a prototype stent with the mixed slurry, performing vacuum drying to obtain a green body, carrying out low-temperature sintering and skimming in protecting gas at the temperature of 1,000-1,200 DEG C to obtain low-strength porous tantalum body, and performing low-temperature sintering and skimming in the protecting gas at the temperature of 1,800-2,500 DEG C to obtain the final customized porous tantalum implant. The net racks and the pellets can form communicated main pipelines and communicated spherical holes, and the main pipelines can prevent passages from blockage, so that nutriment conveying is facilitated, the spherical holes are beneficial to bone cell adhesion and growth, and the elasticity modulus of the implant is equivalent to that of that of the human bone.

Description

[0001] Technical field: [0002] The invention belongs to the field of biomanufacturing of bone substitute implants, in particular to a personalized customized porous tantalum implant and a preparation method thereof. [0003] Background technique: [0004] At present, the bone replacement implants used in medicine are generally titanium alloys, but compared with titanium alloys, tantalum has better performance. On the one hand, the biocompatibility of tantalum is better than that of titanium alloy. A layer of oxide film can be formed on the surface of tantalum, which does not react with acid and alkali at room temperature, so it will not be corroded after being implanted in the human body; on the other hand, tantalum The modulus of elasticity is close to that of human bone, and after implantation in the human body, it can effectively avoid the stress shielding effect and promote the formation of new bone. At present, there are two main methods for preparing porous tantalum. O...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/56
Inventor 刘亚雄陈旭王玲李涤尘靳忠民
Owner 宁波创导三维医疗科技有限公司
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