Traditional Chinese medicine coating agent for preventing and treating piglet diarrhea and preparation method of traditional Chinese medicine coating agent

A technology for piglet diarrhea and film coating, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, antiviral agents, etc. Fast absorption, enhance the effect of tonifying the spleen and kidney

Inactive Publication Date: 2015-08-19
DALIAN NATIONALITIES UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the problems of poor palatability and poor drug efficacy of existing oral Chinese medicines for treating piglet diarrhea, the invention provides a traditional Chinese medicine film-coating agent for preventing piglet diarrhea and a preparation method thereof. The Chinese medicine film-coating agent can be directly applied to the navel of piglets Drug ingredients can be absorbed in the site, quick effect, no drug residue, low cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Weigh 18 parts of Atractylodes macrocephala, 25 parts of plantago seed, 10 parts of woody fragrance, 8 parts of Huoxiang, 7 parts of licorice, 15 parts of Smilax chinensis, 13 parts of Scutellaria baicalensis, 25 parts of astragalus, and crush the raw materials to 120 mesh , put into water with 15 times the mass of each raw material and cook on high heat for 2 hours, and then heat and reflux in 60vt% ethanol at a concentration of 5 times the mass of each raw material to extract 3 times at a temperature of 60°C. Liquid is filtered with filter paper, is mixed with each Chinese medicine fluid extract of 1:1, promptly every 1g raw material obtains 1ml fluid extract;

[0033] (2) Mix each Chinese medicine liquid extract prepared in step (1), collect the supernatant after centrifuging at 1800r / min for 30min, concentrate the supernatant into a mixed liquid extract of 2:1, and set aside;

[0034](3) Polyvinyl alcohol, chitosan and sodium alginate are respectively dissolved ...

Embodiment 2

[0038] (1) Weigh 20 parts of Atractylodes macrocephala, 30 parts of plantago seed, 15 parts of woody fragrance, 10 parts of Huoxiang, 10 parts of licorice, 20 parts of Smilax chinensis, 15 parts of Scutellaria baicalensis, 30 parts of astragalus, and crush the raw materials to 120 mesh , put into water with 15 times the mass of each raw material and cook for 3 hours on high heat, then heat and reflux extract 3 times in 75vt% ethanol at a concentration of 6 times the mass of each raw material after boiling, the extraction temperature is 65°C, and each extract Filter with filter paper, be mixed with each Chinese medicine fluid extract of 1:1, promptly every 1g raw material obtains 1ml fluid extract;

[0039] (2) Mix each Chinese medicine liquid extract prepared in step (1), collect the supernatant after centrifuging at 2000r / min for 20min, concentrate the supernatant into a mixed liquid extract of 2:1, and set aside;

[0040] (3) Polyvinyl alcohol, chitosan and sodium alginate a...

Embodiment 3

[0044] (1) Weigh 30 parts of Atractylodes macrocephala, 35 parts of Plantaginaceae, 25 parts of woody fragrance, 15 parts of Huoxiang, 15 parts of licorice, 22 parts of Smilax chinensis, 18 parts of Scutellaria baicalensis, and 33 parts of Astragalus membranaceus, and crush the raw materials to 120 mesh , put into water with 20 times the mass of each raw material and cook on high heat for 4 hours, then heat and reflux extract 3 times in 65vt% ethanol at a concentration of 5 times the mass of each raw material after boiling, the extraction temperature is 63°C, and each extract Filter with filter paper, be mixed with each Chinese medicine fluid extract of 1:1, promptly every 1g raw material obtains 1ml fluid extract;

[0045] (2) Mix each Chinese medicine liquid extract prepared in step (1), collect the supernatant after centrifuging at 2000r / min for 20min, concentrate the supernatant into a mixed liquid extract of 2:1, and set aside;

[0046] (3) Polyvinyl alcohol, chitosan and...

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PUM

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Abstract

The invention provides a traditional Chinese medicine coating agent for preventing and treating piglet diarrhea as well as a preparation method and application of the traditional Chinese medicine coating agent, belonging to the field of veterinary drugs. The traditional Chinese medicine coating agent is prepared through the following steps of with rhizoma atractylodis macrocephalae, semen plantaginis, radix aucklandiae, agastache rugosus, liquorice, rhizoma smilacis glabrae, radix scutellariae and astragalus as raw materials, smashing the raw materials, and then, boiling, filtering, extracting and concentrating to obtain a liquid extract; and uniformly mixing the liquid extract, a film-forming solution and a penetration enhancer to prepare the traditional Chinese medicine coating agent. The traditional Chinese medicine coating agent can be directly coated on the navel of a piglet, the drug absorption effect can be effectively improved, the effects can be rapidly taken, the optimal curative ratio of piglet diarrhea can be up to 90.0%, a favorable treating effect is achieved, and the traditional Chinese medicine coating agent has the advantages of no skin irritation, antibacterial and anti-inflammation effects, no residues and the like; and the preparation method is simple and easy in process, low in cost and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, and in particular relates to a traditional Chinese medicine coating agent for preventing and treating piglet diarrhea and a preparation method thereof. Background technique [0002] Diarrhea is the most common disease in piglets. Since 2014, the epidemic of piglet diarrhea has occurred in the United States, and nearly 6 million piglets have died. Later, diarrhea epidemics have also occurred in many places. Recently, epidemic diarrhea ransacked Japanese farms again, killing nearly 70,000 pigs. In the face of the epidemic sweeping the world, countries are stepping up the development of drugs against piglet diarrhea. [0003] Piglet epidemic diarrhea is an acute intestinal infectious disease of pigs caused by porcine epidemic diarrhea virus, which is characterized by watery diarrhea, vomiting and dehydration. It is sensitive to ether, chloroform, etc., and has weak resistance to the external enviro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61K9/70A61P1/12A61P31/14
Inventor 杜雄伟李叶邹民发王玉山梁军陈朝喜
Owner DALIAN NATIONALITIES UNIVERSITY
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