Bacterial-cellulose dressing with antibacterial and bacteriostatic functions and preparation method as well as application thereof

A technology of bacterial cellulose and bacterial cellulose film is applied in the field of biomedical materials to achieve the effect of controllable modification reaction degree, good antibacterial and bacteriostatic function, and promoting wound healing.

Active Publication Date: 2015-09-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Bacterial-cellulose dressing with antibacterial and bacteriostatic functions and preparation method as well as application thereof
  • Bacterial-cellulose dressing with antibacterial and bacteriostatic functions and preparation method as well as application thereof
  • Bacterial-cellulose dressing with antibacterial and bacteriostatic functions and preparation method as well as application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Prepare the bacterial cellulose dressing with antibacterial and antibacterial function with low grafting rate and low load according to the following steps:

[0047] (1) Weigh 0.4 g bacterial cellulose dry film with a thickness of about 0.2mm (about 2.46 mmol, the molecular weight of its structural unit is 162 g / mol, the same below) and add it to 100ml LiCl / DMAc solution containing 7% LiCl , stirring slowly for 1 hour at room temperature, so that the bacterial cellulose membrane has obvious uniform swelling, and the thickness reaches about 1.0mm;

[0048] (2) After raising the temperature of the bacterial cellulose system above to 50°C, add 0.6 g of maleic anhydride under stirring conditions, without adding a catalyst, and continue stirring for 2 hours;

[0049] (3) After the reaction is completed, fully wash the bacterial cellulose membrane in a sufficient amount of anhydrous methanol;

[0050] (4) Transfer the cleaned bacterial cellulose membrane to 50ml methanol sol...

Embodiment 2

[0055] Prepare the bacterial cellulose dressing with antibacterial and antibacterial function in the grafting rate in the following steps:

[0056] (1) Weigh 0.2 g dry film of bacterial cellulose (about 1.23 mmol) with a thickness of about 0.1 mm and add it to 100 ml of LiCl / DMAc solution containing 8% LiCl, and stir slowly for 3 hours at room temperature to make the bacterial cellulose film There is obvious uniform swelling, and the thickness reaches about 1.5mm;

[0057] (2) After raising the temperature of the bacterial cellulose system above to 65°C, add 0.85g of maleic anhydride and 0.01g of DMAP catalyst under stirring conditions, and continue stirring for 3 hours;

[0058] (3) After the reaction is completed, fully wash the bacterial cellulose membrane in a sufficient amount of absolute ethanol;

[0059] (4) Transfer the cleaned bacterial cellulose membrane to 50ml ethanol solution containing 0.01mol / L zinc acetate, and stir continuously at 50°C for 1.5h;

[0060] (5)...

Embodiment 3

[0065] Prepare the bacterial cellulose dressing with antibacterial and antibacterial function in the high grafting rate according to the following steps:

[0066] (1) Weigh 0.2 g bacterial cellulose dry film (about 1.23 mmol) with a thickness of about 0.2 mm and add it to 100 ml of LiCl / DMAc solution containing 10% LiCl, and stir slowly for 3 hours at room temperature to make the bacterial cellulose film There is obvious uniform swelling, and the thickness reaches about 2.0mm;

[0067] (2) After raising the temperature of the bacterial cellulose system above to 60°C, add 1.2g of maleic anhydride and 0.015g of DMAP catalyst under stirring conditions, and continue stirring for 3 hours;

[0068] (3) After the reaction is completed, fully wash the bacterial cellulose membrane in a sufficient amount of absolute ethanol;

[0069] (4) Transfer the washed bacterial cellulose membrane to 50ml ethanol solution containing 0.02mol / L zinc acetate, and stir continuously at 50°C for 1.5h; ...

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Abstract

The invention relates to a bacterial-cellulose dressing with antibacterial and bacteriostatic functions and a preparation method as well as application thereof, and belongs to the field of biomedical materials. The dressing comprises bacterial cellulose and nano zinc oxide, wherein the nano zinc oxide is loaded onto the bacterial cellulose in the manner of a reaction in-situ. The preparation method comprises the following steps of after the bacterial cellulose is subjected to swelling treatment to some extent, reacting the bacterial cellulose with an acid anhydride in an anhydrous solvent for modification, and then, loading the nano zinc oxide inside the bacterial cellulose through the reaction in-situ, and sufficiently cleaning and drying a product to obtain the bacterial-cellulose dressing with the antibacterial and bacteriostatic functions. In the procedures of the method, the modification extent of the bacterial cellulose can be effectively controlled; the effective and stable loading of the nano zinc oxide is realized; the obtained product is stable in performances, and can be stored for a long time. The obtained bacterial-cellulose dressing with the antibacterial and bacteriostatic functions has favorable biocompatibility, and can be applied to a body-surface wound surface with certain adaptation diseases.

Description

technical field [0001] The invention relates to a bacterial cellulose dressing with antibacterial and antibacterial functions, a preparation method and application thereof, and belongs to the field of biomedical materials. technical background [0002] Bacterial cellulose is an important natural polymer material, which is widely used in various fields of tissue engineering because of its good biocompatibility. Due to the good mechanical properties and excellent water retention capacity of bacterial cellulose materials, their application in wound dressings has attracted great attention. In the clinical process, body surface wounds are often accompanied by infection, and bacterial cellulose itself has no antibacterial and antibacterial ability, so it is difficult to be used for large-area burn wounds with high infection risks and chronic refractory wounds. Bacterial cellulose wound dressings have put forward new requirements. Functional wound dressings can effectively improv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/36A61L15/18A61L15/42A61L15/44
Inventor 林海樊渝江张兴栋
Owner SICHUAN UNIV
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