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Rivaroxaban tablets and preparation method thereof

A technology for rivaroxaban and tablets, applied in the field of medicine, can solve the problems of difficulty in guaranteeing mixing uniformity, large particle size difference, etc., and achieve the effects of improving drug safety and simple preparation process

Active Publication Date: 2015-09-09
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new technology simplifies the manufacturing processes while maintaining its benefits such as ease-of use, improved security during storage or transport, quicker release time when needed, easy handling by users, etc., making it ideal for large scale commercialization purposes like pharmaceutical companies.

Problems solved by technology

This patented describes different methods for making drugs called rivarximab that have good water solubilities and faster disintegration rates compared to existing ones like rivarimod gelatin. These new techniques involve improving the properties of these agents through specific design principles and combining them together into one entity.

Method used

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  • Rivaroxaban tablets and preparation method thereof
  • Rivaroxaban tablets and preparation method thereof
  • Rivaroxaban tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024]

[0025] Preparation Process:

[0026] Rivaroxaban was crushed through an 80-mesh sieve, and the prescription amount was weighed, added to a pure aqueous solution of sucrose, stirred evenly, and then added to a nano-bead mill for grinding until the particle size D90 was 480nm; the suspension was used as The adhesive is granulated on a mixed powder of microcrystalline cellulose, pregelatinized starch and sodium carboxymethyl starch, dried at 60°C, granulated through a 18-mesh sieve, added with magnesium stearate, mixed evenly, and pressed into tablets.

Embodiment 2

[0028]

[0029] Preparation Process:

[0030] Rivaroxaban was crushed through an 80-mesh sieve, and the prescription amount was weighed, added to a pure aqueous solution of sucrose, stirred evenly, and then added to a nano-bead mill for grinding until the particle size D90 was 180nm; the suspension was used as The binder is granulated on a mixed powder of microcrystalline cellulose, lactose and croscarmellose sodium, dried at 60°C, granulated with a 18-mesh sieve, added with magnesium stearate, mixed evenly, and pressed into tablets.

Embodiment 3

[0032]

[0033] Preparation Process:

[0034] Rivaroxaban was crushed through an 80-mesh sieve, and the prescription amount was weighed, added to a pure aqueous solution of sucrose, stirred evenly, and then added to a nano-bead mill for grinding until the particle size D90 was 150nm; the suspension was used as The adhesive is granulated on a mixed powder of microcrystalline cellulose and crospovidone, dried at 60°C, granulated with a 18-mesh sieve, added with magnesium stearate, mixed evenly, and compressed into tablets.

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Abstract

The present invention belongs to the technical field of medicine, and particularly relates to rivaroxaban tablets and a preparation method thereof. The preparation method comprises: dispersing rivaroxaban in an aqueous solution containing sucrose, adding to a nanometer bead mill to grind, granulating the obtained suspension on a pharmaceutically-acceptable excipient, drying, adding a lubricant, uniformly mixing, and tabletting. According to the present invention, the preparation process is simple, and the raw material does not require the separate micro-powder treatment; any surfactants are not added so as to improve medication safety; the drug dissolution is rapid, wherein the 5 min dissolution achieves more than or equal to 90%; and the preparation process is simple, and the method is suitable for industrial production.

Description

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Claims

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Application Information

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Owner SHANDONG NEWTIME PHARMA
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