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Application of aloperine in the preparation of drugs for treating myocardial hypertrophy

A technology for myocardial hypertrophy and sophorine, which can be used in drug combinations, pharmaceutical formulations, cardiovascular system diseases, etc., and can solve problems such as decompensated myocardial hypertrophy and heart failure.

Active Publication Date: 2019-01-29
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But as the overload persists, this compensatory mechanism can develop into decompensated cardiac hypertrophy, leading to heart failure

Method used

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  • Application of aloperine in the preparation of drugs for treating myocardial hypertrophy
  • Application of aloperine in the preparation of drugs for treating myocardial hypertrophy
  • Application of aloperine in the preparation of drugs for treating myocardial hypertrophy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The purposes of aloperine in the preparation of the medicine for treating cardiac hypertrophy, wherein, the molecular structural formula of aloperine is as shown in formula (1):

[0025]

[0026] The single application dose of aloperine in rats is 10 mg / kg body weight, and the dosage form of the medicine is a pharmaceutically allowed powder injection dosage form.

Embodiment 2

[0028] The purposes of aloperine in the preparation of the medicine for treating cardiac hypertrophy, wherein, the molecular structural formula of aloperine is as shown in formula (1):

[0029]

[0030] The single application dose of aloperine in rats is 20 mg / kg body weight, and the dosage form of the medicine is an injection dosage form allowed in pharmacy.

Embodiment 3

[0032] The purposes of aloperine in the preparation of the medicine for treating cardiac hypertrophy, wherein, the molecular structural formula of aloperine is as shown in formula (1):

[0033]

[0034] The single application dose of aloperine in rats is 40 mg / kg body weight, and the dosage form of the medicine is an oral dosage form allowed in pharmacy.

[0035] The effect of embodiment 1-3 can be verified by following animal experiments:

[0036] 1 Experimental materials

[0037] 1.1 Animals

[0038] Spargue-Dawley (SD) rats, weighing 280-320 g, were provided by the Animal Experiment Center of Ningxia Medical University.

[0039] 1.2 Drugs, reagents and instruments

[0040] Aloperine powder (Ningxia Zijinhua Pharmaceutical Co., Ltd., purity 99%); isoproterenol; cTnI and ADMA kits; SOD, GSH-PX and MDA kits; low-temperature high-speed centrifuge; standard instrument.

[0041] 1.3 Preparation of medicine

[0042] Preparation of 0.5% sodium carboxymethylcellulose (CMC) ...

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Abstract

The invention discloses application of aloperine serving as a drug for treating myocardial hypertrophy. Due to the fact that a rat myocardial hypertrophy model is established, the protecting effect and the mechanism of the aloperine on rat myocardial hypertrophy are explored and researched. An experiment result shows that when the aloperine is used within the safety dosage range, certain dosage-drug function relevance is shown when the dosage is 40 mg / kg, the heart weight, the left ventricle weight, the whole ventricle mass / the body mass and the left ventricle mass / the body mass can be remarkably improved, myocardial fibrosis is remarkably inhibited, cardiomyocyte hypertrophy and cardiomyocyte necrosis are reduced, myocardial compliance and the left ventricle diastole function are improved, myocardial contractility is improved, the serum NO concentration is improved, SOD activity and GSH-Px activity are improved, the ADMA level is reduced, the cTn-I content and the MDA content are reduced, the body oxidation resistance is improved, the lipid peroxidation level is reduced, and it is shown that the aloperine has the function of treating the myocardial hypertrophy.

Description

technical field [0001] The present invention relates to the application of aloperine (Aloperine, ALO), in particular to the application of aloperine in the preparation of drugs for treating myocardial hypertrophy. Background technique [0002] Cardiac hypertrophy is the adaptive response of the heart to adapt to various mechanical and neurohormonal stimuli. During the compensatory phase, the heart improves its pumping function by increasing the work output of the cardiomyocytes. But as the overload persists, this compensatory mechanism can develop into decompensated myocardial hypertrophy, leading to heart failure. The pathological changes of cardiac hypertrophy include the hypertrophy of cardiomyocytes and the proliferation and differentiation of fibroblasts, which are manifested as the increase of heart volume and mass. [0003] Nitric oxide (NO) is a vasodilator factor synthesized and released by vascular endothelial cells. It is formed with L-arginine as a substrate an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4748A61P9/00A61P9/04
Inventor 周茹郑婕郝银菊姚婉霞徐清斌张鹏汪静杜娟吴淑霞戴贵东
Owner NINGXIA MEDICAL UNIV
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