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A kind of Bacillus subtilis spray

A Bacillus subtilis, spray technology, applied in the direction of aerosol delivery, bacteria, organic active ingredients, etc., can solve the problems of poor film-forming effect, poor hemostatic effect, single effect, etc., to achieve acceleration, prevent infection aggravation, growth-inhibiting effect

Active Publication Date: 2016-08-17
H H T WHITE SWAN PHARMACY GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] One of the objectives of the present invention is to solve the problem of low survival rate and poor film-forming effect when the Bacillus subtilis inoculum is applied to the treatment of burns in order to solve the problem of drug resistance in the existing treatment of burns, and to provide a Bacillus subtilis spray agent
[0010] Another purpose of the present invention is to solve the problem that the existing Bacillus subtilis inoculum has too single effect and poor hemostatic effect when applied to burn treatment, and provides a kind of application of Bacillus subtilis spray

Method used

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  • A kind of Bacillus subtilis spray
  • A kind of Bacillus subtilis spray
  • A kind of Bacillus subtilis spray

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specific Embodiment approach 1

[0022] Specific embodiment one: this embodiment is a kind of Bacillus subtilis spray, and it is made up of Bacillus subtilis and matrix; The bacterial content of Bacillus subtilis in described Bacillus subtilis spray is 5.6~5.9×10 8 CFU / mL; the matrix is ​​composed of 85-94% nutrient solution, 5-10% glycerin and 1-5% dispersant by mass percentage, and the nutrient solution is composed of carbon source, nitrogen source, It is made by mixing inorganic salt and water, wherein the concentration of carbon source in the nutrient solution is 3-5mg / mL, the concentration of nitrogen source in the nutrient solution is 10-13mg / mL, and the concentration of inorganic salt in the nutrient solution is 0.05-0.1mg / mL The carbon source is composed of glucose, aloe polysaccharide and mint polysaccharide in a mass ratio of 1: (2-3): (2-3); the nitrogen source is soybean peptone, yeast powder, beef extract or soybean powder; the dispersant is sodium naphthalenesulfonate formaldehyde condensate or ...

specific Embodiment approach 2

[0033] Specific embodiment two: the difference between this embodiment and specific embodiment one is that the inorganic salt is composed of 0.05% by mass percentage of calcium chloride solution, 0.05% by mass percentage of manganese chloride solution, The magnesium sulfate solution with a mass percentage of 0.1% and the disodium hydrogen phosphate solution with a mass percentage of 0.2% are mixed in equal proportions. Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0034] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the carbon source is composed of glucose, aloe polysaccharide and mint polysaccharide in a mass ratio of 1:2:2. Other steps are the same as those in Embodiment 1 or 2.

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Abstract

The invention relates to a bacillus subtilis spray, which relates to a spray. One of the purposes of the present invention is to solve the problems of drug resistance existing in the existing medicines for treating burns. When the Bacillus subtilis bacterial agent is applied to the burn treatment, the effect is too single and the hemostatic effect is poor. It is prepared from bacillus subtilis, 85-94% nutrient solution, 5-10% glycerin and 1-5% dispersant. The invention relates to a bacillus subtilis spray, which is used for antibacterial infection of burns. The bacillus subtilis (BS224) spray of the present invention implants the dominant bacteria on the wound to rapidly form a bacterial film and utilize the biological antagonism thereof to play a biological barrier and antibacterial effect on the burn wound. The bacillus subtilis spray prepared by the invention is used for antibacterial infection of burns.

Description

technical field [0001] The invention relates to a spray and its application. Background technique [0002] Burns are common sores both in peacetime and in wartime, and are generally treated with thermal burns (including hot liquids, such as water, soup, oil, etc., steam, high-temperature gas, flames, hot metal or plastic liquids and solids, such as molten steel, steel ingots, etc.) High temperature plastics, etc.) mainly. With the development of modern industrial and agricultural production technology, chemical and electronic burns show an increasing trend, which can cause batches of wounded in forest fires, flammable and explosive, fires in public places and modern wars. [0003] Burn infection is an important cause of wound deepening and sepsis, so prevention and control of wound infection is a content of burn research. Due to the tissue necrosis caused by burns, a good culture environment for the growth and reproduction of microorganisms is formed, and the local circula...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/742A61K9/12A61P17/02A61K31/715A61K31/717A61K31/734
Inventor 周云久鲁丽杨慧姜玉娟冯媛肖颖于凯吕雪董志玲
Owner H H T WHITE SWAN PHARMACY GRP
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