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Bioactive coating on the surface of a porous metal material and its preparation method

A porous metal, bioactive technology, applied in the field of biomedical materials, to achieve the effects of strong controllability, warm conditions, and easy batch production

Active Publication Date: 2017-05-31
CHANGZHOU GEASURE MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no coating or its preparation technology that can satisfy this ideal condition at the same time

Method used

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  • Bioactive coating on the surface of a porous metal material and its preparation method
  • Bioactive coating on the surface of a porous metal material and its preparation method
  • Bioactive coating on the surface of a porous metal material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Low porosity porous titanium features: cylindrical (Φ8×20 mm), porosity ~40%, macropore size: ~230 microns, such as figure 2 shown.

[0054] 1) Preprocessing

[0055] a) Degreasing: Wash the porous titanium with ultrasonic oscillation in acetone and ethanol for 5-10 minutes in turn, repeat twice, then wash twice with ultrasonic oscillation in deionized water for later use.

[0056] b) Acid-base treatment: Immerse the deoiled porous titanium in 2M HNO 3 solution, put it at room temperature for half an hour, take it out, rinse it with deionized water until it is neutral; then, immerse it in a polytetrafluoroethylene cup filled with 6 M NaOH solution, keep it in an oven at 60°C for 4 hours, and remove it. Ultrasonic cleaning with deionized water until the pH of the washing solution is close to neutral. The typical multi-pit network morphology of the porous titanium surface after strong alkali treatment is as follows: image 3 shown.

[0057] 2) Anodizing treatment

...

Embodiment 2

[0070] High porosity porous titanium features: cylindrical shape (Φ8×20 mm), porosity ~73%, macropore size ~400 microns, such as Figure 5 shown.

[0071] 1) pretreatment and anodic oxidation step are with embodiment 1;

[0072] 2) Pulse electrodeposited calcium phosphate coating

[0073] The composition of the electrolyte, the pouring of the porous titanium and the electrodeposition temperature are the same as those in Example 1. The cathodic electrodeposition conditions are: the cathode pulse current density is 6 mA / cm 2 , the pulse duration is 0.8s, the pulse pause (current density is 0) time is 9.2s, mechanical stirring, electrodeposition (counted by the number of cycles) ends after 90 cycles, soaked in deionized hot water and washed three times before use.

[0074] 3) Hydrothermal treatment: Same as Example 1. After steps 2) and 3), the surface morphology of porous titanium is as follows Image 6 shown.

Embodiment 3

[0075] Example 3: Characterization of Porous Titanium Surface Coatings

[0076] Taking the coating prepared in Example 1 as an example, the coating structure, thickness, crystal form and adhesion of the surface calcium phosphate were evaluated.

[0077] 1) Coating structure and thickness

[0078] Figure 7 The typical cross-sectional morphology of the multilayer coating prepared on the porous titanium surface of the present invention is shown. The thickness of the HAP coating prepared under the conditions of Example 1 is 1.0 micron, and the thickness of the dense oxide film and intermediate gel layer on the titanium surface is about 0.5 micron.

[0079] 2) Crystal form and composition of calcium phosphate on coating surface

[0080] Typical XRD characteristics of coatings on porous titanium surfaces ( Figure 8 ), the four strongest diffraction peaks correspond to the main characteristic peaks of HAP. At the same time, the characteristic peaks of TiO2 and titanium also app...

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Abstract

The invention relates to a bioactive coating on the surface of a porous metal material and a preparation method of the bioactive coating and belongs to the field of biomedical materials. The preparation method of the bioactive coating is characterized by preparing a multilayer coating on the surface of the porous metal material by chemical and electrochemical methods; the method is simple in preparation process, short in consumed time and high in repeatability; the controllable batch production is liable to implement. The bioactive coating prepared by the method has a three-layer microstructure, wherein a bottom layer serving as a metal surface is a metal oxide dense layer; a middle layer is a metal oxide gel layer; a top layer serving as the surface layer is a calcium phosphate film layer; the thickness and microstructures of the three film layers can be regulated in a range from nano to micron according to the requirements. The bioactive coating has the function of inhibiting self-corrosion of substrate metal, also has the characteristics of high substrate adhesion, high specific surface area and abundant micropores, can be used for greatly improving osteoconduction and even osteo inductivity of the porous metal material, and is especially applicable to repairing or replacement of bone defect of weight bearing parts.

Description

technical field [0001] The invention relates to a bioactive coating on the surface of a porous metal material and a preparation method thereof, belonging to the field of biomedical materials. [0002] technical background [0003] The excellent mechanical properties of metal materials make them widely used in the field of biomedicine, especially in orthopedics. [0004] Titanium and its alloys have good biocompatibility, low toxicity, sufficient mechanical strength and corrosion resistance, so they have become the materials of choice for replacement of damaged hard tissues (teeth, joints, etc.) in the weight-bearing parts of the human body. However, titanium and its alloys without special surface treatment are biologically inert. Due to the difficulty of forming effective osseointegration with the surrounding tissue, this kind of surface bioinert implant often leads to loosening of the implant and chronic inflammation, and finally has to be removed by a second operation, whi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25D11/26C25D9/08C25D5/18C25D5/48
Inventor 朱向东肖占文陈宏杰王春利张凯樊渝江张兴栋
Owner CHANGZHOU GEASURE MEDICAL DEVICES CO LTD
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