Magnetic resonance imaging method and application based on spin-locking technology to detect oscillating magnetic field

Abstract

The invention discloses a magnetic resonance imaging method used for oscillatory magnetic field detection and based on a spin-locked technology and application, and names as Spin-Locked Oscillatory Excitation, SLOE. SLOE comprises a spin-locked preparation sequence insensitive to main magnetic field and radio frequency field inhomogeneity and spin planar echo acquisition. According to the method, after the spin-locked preparation sequence, any additional excitation pulse is no longer applied, and all acquired signals are magnetization vector signals deflected by oscillatory magnetic field excitation. In a data processing process, due to the fact that the initial phase of oscillatory current scanned every time is random, the fluctuation of a check signal time sequence is statistically used to detect an activation signal. According to the invention, defects of conventional neuronal discharge sequence detection are solved; the sensitivity of tiny oscillatory magnetic field detection is greatly improved; neuronal discharge can be successfully detected through magnetic resonance detection in vivo; and technological innovation in the field can be promoted.

Description

technical field [0001] The invention relates to the field of magnetic resonance imaging, and relates to a magnetic resonance imaging method and application for detecting an oscillating magnetic field based on a spin-locking technology, in particular to an application of the magnetic resonance method for neuron current magnetic resonance imaging. Background technique [0002] The functional Magnetic Resonance Imaging (fMRI) method based on Blood-Oxygen-Level-Dependence (BOLD) has achieved unprecedented development since Ogawa et al. BOLD fMRI has now become an important research tool in cognitive neuroscience. However, the BOLD principle is mainly based on the change of the magnetization properties of deoxyhemoglobin based on the hemodynamic response, and the hemodynamic response itself is a very slow process (on the order of 1s) in the living body, and its speed is much lower than that of the nervous system. Therefore, BOLD fMRI detection of neural activity has a relatively...

AI Technical Summary

Problems solved by technology

However, such detection methods have not yielded consistent positive results

The main reasons are that the contrast between the magnetic field caused by neuron discharge and the change of BOLD magnetic field is smaller, and there are: 1) the interference of BOLD signal during the imaging time; The signals cancel each other out; 3) The spatial arrangement of neurons causes the collective firing of different neurons to cancel each other out

The first two reasons are insurmountable by GE-EPI technology itself

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