The invention discloses a cross-
modal sEEG-to-iEEG generation method based on a multi-scale condition regularization
stream, and the method comprises the steps: obtaining sEEG and iEEG signals which are collected synchronously, and carrying out the preprocessing, and obtaining qualified condition input and target signals; then, a multi-scale conditional regularization flow model containing a multi-scale framework, multiple processes and a core reversible transformation module is constructed, and iEEG
signal distribution conversion is achieved through reversible channel
hybrid operation and a conditional affine
coupling layer; training the model by using a maximum likelihood
estimation method, and optimizing parameters until convergence; and after a new sEEG
signal is preprocessed, inputting the trained model, and generating a corresponding iEEG
signal through inverse transformation. According to the method, complex probability distribution is modeled through conditional regularization flow, mode collapse is avoided,
nerve activity randomness is reserved, deep
temporal lobe full-region iEEG generation is achieved by combining a multi-scale framework with a self-attention mechanism, high-fidelity iEEG is generated in a non-invasive mode, medical risks and cost are reduced, and the method is suitable for large-scale popularization and application. And reliable
technical support is provided for epileptic focus positioning and
cognitive neuroscience research.