Novel bone ununion experiment model and manufacturing method for same

An experimental model and nonunion technology, applied in the field of basic medical experiments, can solve the problems of not being able to imitate the real state of high-energy fractures, not being able to effectively prevent nonunion, and not being able to display

Inactive Publication Date: 2015-09-23
潘治军
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  • Application Information

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Problems solved by technology

As for the reason of nonunion, it can only show the impact of bone defect and damage to the inner and outer periosteum on fracture healing, but cannot show the many other causes of nonunion, let alone show the "neither bone defect nor Absence of callus growth in "unstable" conditions - a disorder of callus formation
It also cannot imitate the real state of high-energy fractures, so it cannot reveal the biological mechanism that causes bone nonunion, so it cannot effectively prevent bone nonunion

Method used

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  • Novel bone ununion experiment model and manufacturing method for same
  • Novel bone ununion experiment model and manufacturing method for same
  • Novel bone ununion experiment model and manufacturing method for same

Examples

Experimental program
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Embodiment Construction

[0028] 1. Experimental steps

[0029] 1) Preparation of canine femur simple fracture combined with occult soft tissue injury model: Randomized controlled animal experiments were used. 20 experimental dogs were randomly divided into experimental group and control group, 10 dogs in each group. Intramuscular injection anesthesia with Sumianxin II at a dose of 0.15mL / kg in the neck. Routine skin preparation, disinfection, and draping. A fine Kirschner wire was driven into the greater trochanter and the femoral condyle as a mark, and the distance between the two marked pins was measured and recorded with a scale, and the midpoint of the femoral shaft was determined at the same time. Pierce percutaneously with a Kirschner wire at the midpoint of the femoral shaft, pass through the muscle layer to reach the bone cortex, and drill through the double cortex three times in different directions perpendicular to the longitudinal axis of the shaft to reduce the bone strength. Adjacent p...

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Abstract

The invention relates to a novel bone ununion experiment model and a manufacturing method for the same. A simple fracture with closed femur is manufactured when two fracture ends are adjacent to muscle and then operation for open reduction 8-hole internal fixation with a steel plate is conducted, so fracture ends are aligned upon anatomy and no bone defect is left; necrosis seepage cavity is formed in fracture part after two weeks of operation; internal and external callus growth can be prevented after ten weeks of the operation; bone end absorbs; fracture gap is enlarged and scar is filled in the gap; the steel plate and screws loose; and an atrophic bone ununion model is established.

Description

1. Technical field [0001] The invention belongs to the technical field of basic medical experiments, and in particular relates to a novel nonunion experimental model and a manufacturing method thereof. 2. Technical background [0002] The traditional method of making a nonunion model is to create a bone defect equal to the diameter of the diaphysis, or to create a smaller bone defect + destroy the inner and outer periosteum. This model can only show the current situation after nonunion occurs, so that it can be used to study the treatment of nonunion. As for the reason of nonunion, it can only show the impact of bone defect and damage to the inner and outer periosteum on fracture healing, but cannot show the many other causes of nonunion, let alone show the "neither bone defect nor Absence of callus growth in "unstable" conditions - impaired callus formation. It also cannot imitate the real state of high-energy fractures, so it cannot reveal the biological mechanism that c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00G09B23/30G09B23/36
Inventor 潘治军李忠杨振邦潘静心杜苗
Owner 潘治军
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