Whole blood perfusion bioartificial liver system

A bioartificial, perfusion technology, applied in the medical field, can solve the problems of increasing patient waiting time, increasing the risk of system pollution, and prolonging treatment time, so as to improve the efficiency of material exchange, reduce the burden on the kidneys, and increase the effect of liquid convection

Active Publication Date: 2015-10-07
WEST CHINA HOSPITAL SICHUAN UNIV
View PDF9 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the biological hepatic circulation part is the main body, which is based on the cultivation of liver cells, with the bioreactor as the core carrier, providing functions such as secretion, metabolism, biotransformation and detoxification, and basically includes the following parts: bioreactor, circulation pump, thermostat , oxygenator and ci

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Whole blood perfusion bioartificial liver system
  • Whole blood perfusion bioartificial liver system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0024] Such as figure 1 The whole blood perfusion bioartificial liver system disclosed in the present invention includes four parts: blood circulation part, biohepatic circulation part, liquid input part and dialysate discharge part, and the four parts are connected through connecting pipelines or hollow fiber semi-permeable membranes. The blood circulation part includes blood input port 1, blood pump 2, heparin pump 19, defoamer A3, hollow fiber column 4, defoamer A3, blood return port 5 connected in sequence, and hollow fiber column 4 is a high-throughput The hollow fiber column (hollow fiber membrane molecular cutoff is 60-67kD), the blood pump 2 draws the blood in the human body, and the heparin pump 19 seals the tube.

[0025] The biological liver circulatio...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a whole blood perfusion bioartificial liver system which comprises a blood circulation part and a bioartificial liver circulation part. The blood circulation part comprises a blood input port, a blood pump, a hollow fiber column and a blood feedback port which are sequentially connected. The bioartificial liver circulation part comprises a circulation pump, a constant temperature heater, an oxygenator and a bioreactor which are sequentially connected. An inlet of the circulation pump is connected with an outlet of an outer cavity of the hollow fiber column. A liquid outlet of the bioreactor is connected with an inlet of the outer cavity of the hollow fiber column. The bioartificial liver circulation part is further provided with two bypass pipelines. The whole blood perfusion bioartificial liver system further comprises a liquid input part and a dialyzate drainage part. The whole blood perfusion bioartificial liver system is safe, reliable and efficient, achieves continuous treatment, combines the venous transfusion and part kidney dialysis functions, is comprehensive, and provides effective support for hepatic failure patients.

Description

technical field [0001] The present invention and the medical field particularly relate to a whole blood perfusion bioartificial liver system. Background technique [0002] my country is the country with the most serious liver disease in the world, with more than 1 million new cases of liver failure each year, and about 500,000 liver failure patients die each year due to lack of effective treatment. The mortality rate of liver failure is extremely high, and the effect of conservative medical treatment is not good. As one of the effective treatment methods for patients with severe hepatitis and liver failure, artificial liver support therapy has been recognized all over the world. At present, people are working on the research and development of various artificial livers, especially biological and hybrid artificial livers, hoping that they can replace the damaged liver to perform related functions and help patients recover themselves or wait for liver transplantation. Among t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61M1/16
CPCA61M1/1627A61M1/1694
Inventor 包骥步宏
Owner WEST CHINA HOSPITAL SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap