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Fluorescent recognition cupper ion (CU2+) sensor molecules and composition and application thereof

A fluorescence recognition and copper ion technology, applied in the field of cation detection and chemical synthesis, can solve the problem of fewer chemical sensors

Inactive Publication Date: 2015-10-07
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few reports on chemical sensors for copper ion detection.

Method used

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  • Fluorescent recognition cupper ion (CU2+) sensor molecules and composition and application thereof
  • Fluorescent recognition cupper ion (CU2+) sensor molecules and composition and application thereof
  • Fluorescent recognition cupper ion (CU2+) sensor molecules and composition and application thereof

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Embodiment Construction

[0035] The structure and synthesis of the sensor molecule of the present invention, the fluorescence recognition method for copper ions, the preparation and application of the detection test paper will be described in detail below through specific examples.

[0036] 1. Synthesis and characterization of sensor molecules

[0037] In a 250 mL round bottom flask, add 0.237 g (1.5 mmol) of naphthalene diamine, 0.770 g (4.0 mmol) of N,N-diethyl salicylaldehyde, 1 mL (0.017 mmol) of glacial acetic acid for catalyst, 30 mL of N,N- Dimethylimide (DMF) was used as a solvent, refluxed and stirred at 85°C for 8 hours, a yellow precipitate was precipitated, and the crude product was recrystallized with DMF to obtain a brownish-yellow crystal, which was the sensor molecule T. The yield: 83% (m.p. > 300°C). Its structure is characterized as follows:

[0038] 1 H NMR (DMSO– d 6 , 400 MHz) ? / ppm1.16 (t 12H,-CH 3 ), 3.41 (m 8H,-CH 2 -), 8.78 (s 1H, N CH),6.38-8.05 (m 12H, ArH),. IR (KBr)...

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Abstract

The invention discloses fluorescent recognition copper ion (CU2+) sensor molecules and belongs to the field of chemical synthesis and cation detection. DMF as solvent, glacial acetic acid as a catalyst and N,N-diethyl salicylic aldehyde and naphthalene diamine as a substrate are subjected to a reflux reaction and then are subjected to cooling, suction filtration, washing and recrystallization, and then brown yellow crystals are obtained. Experiments show that in a DMSO / H2O HEPES buffer system for the sensor molecules, only CU2+ can be added to quench green fluorescence of the system under an ultraviolet lamp, but other cations cannot quench fluorescence of the system when added; only CU2+ can enable the color of the system to change from yellow to colorless, but other cations cannot enable the color of the system to change when added. Thus, the sensor can be used for quick naked-eye detection of CU2+, the lowest fluorescence detection limit of the sensor can reach 3.37*10-8M, and the other cations have no obvious interference on recognition of CU2+.

Description

technical field [0001] The present invention relates to a copper ion sensor molecule and a synthesis method thereof, in particular to a sensor molecule for fluorescently recognizing copper ions; the present invention also relates to the application of the sensor molecule for highly selective fluorescently recognizing copper ions, belonging to the field of chemical synthesis and cationic detection field. Background technique [0002] Among the indispensable trace elements in the human body, the content of copper ranks third after iron and zinc. Copper plays a vital role in the human body. For example, it is an important component of blood, liver and brain proteins. It also has an important impact on iron metabolism and the hematopoietic function of the human body. However, there are also strict standards for the content of copper in the human body, too much or too little will cause harm to various functions of the human body. If the content is lower than the normal standard...

Claims

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Application Information

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IPC IPC(8): C07C251/24C07C249/02C09K11/06G01N21/64G01N21/78
Inventor 张有明逯桃桃王芹芹林奇姚虹魏太保
Owner NORTHWEST NORMAL UNIVERSITY
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