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A compound preparation for external use

A compound preparation, hyaluronic acid technology, applied in the field of medicine, can solve problems such as side effects, and achieve the effect of avoiding side effects

Active Publication Date: 2018-04-27
QINGDAO HUINUODE BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because this type of drug has a certain curative effect, it is the main drug commonly used in treatment, but frequent use of effective doses of corticosteroids will cause systemic or local side effects, therefore, large doses of corticosteroids must be avoided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Objective: Production method of bioactive hyaluronic acid fragments.

[0024] Method: The raw material is 800-1500KD macromolecular hyaluronic acid with a purity of 90.0%-99.9%, which is cut with recombinant human hyaluronidase PH20 produced by CHO cells, and 2000-4000 units of hyaluronidase is used per gram of hyaluronic acid. Digest at 37 degrees for 4-6 hours, pH5.0-5.5, 130-160mM NaCl, 0.5-1.0mM MgSO 4 , 1.5~2.5mM CaCl 2 , the final molecular weight is 0.7KD ~ 300KD hyaluronic acid fragments; said hyaluronic acid fragments with a molecular weight of 0.7KD ~ 300KD have glycosylated hyaluronic acid that does not cause human allergic reactions produced by CHO cells and can recognize normal hyaluronic acid The cleaved end of recombinant human hyaluronidase PH20 has the biological activity of promoting cell secretion of defensin 2, killing microorganisms and inhibiting inflammation of skin and mucous membranes. The biological activity depends on the hyaluronic acid clea...

Embodiment 2

[0026] Objective: To compare the anti-inflammatory effects of bioactive hyaluronic acid carbomer gel and synthetic corticosteroid triamcinolone acetonide carbomer gel on skin wounds.

[0027] Method: manufacture 3.0% carbomer gel of 3% bioactive hyaluronic acid 15 g / branch (preparation 1); manufacture 3.0% carbomer gel of 3% bioactive hyaluronic acid and contain 0.2 mg triamcinolone acetonide 15 g / branch (preparation 2); manufacture 3.0% carbomer gel containing 1 mg triamcinolone acetonide 15 g / branch (preparation 3); manufacture 1.5% bioactive hyaluronic acid and contain 3.0% of 0.2 mg triamcinolone acetonide Carbomer gel 15 g / branch (preparation 4); manufacture 3.0% carbomer gel containing 0.2 mg triamcinolone acetonide 15 g / branch (preparation 5). Compare the anti-inflammatory effects of the above five preparations on skin wounds, apply 2ml 3 times a day, and observe the redness, swelling and pain on the first day of the wounds formed by skin laser treatment in each prepara...

Embodiment 3

[0033] Objective: To compare the anti-inflammatory effects of bioactive hyaluronic acid + low-dose triamcinolone acetonide spray and high-dose triamcinolone acetonide spray on nasal mucosa.

[0034] Method: make 3% bioactive hyaluronic acid nasal spray (preparation 1), 5 sprays in each nostril; manufacture 3% bioactive hyaluronic acid nasal spray containing triamcinolone acetonide 0.1mg / 12ml (preparation 2), spray in each nostril 5 sprays; manufacture 1.5% biologically active hyaluronic acid containing triamcinolone acetonide 0.1mg / 12ml nasal spray (preparation 3) manufacture triamcinolone acetonide 1.1mg / 12ml nasal spray (preparation 4), 5 sprays per nostril; Comparing the therapeutic effects of the above four preparations on seasonal allergic rhinitis and cold and flu, the evaluation symptoms mainly include nasal itching, nasal obstruction, runny nose and sneezing. Efficacy evaluation of signs: markedly effective: signs of nasal itching, nasal obstruction, runny nose and sne...

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PUM

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Abstract

The invention discloses an external compound preparation, which includes bioactive hyaluronic acid with anti-inflammatory activity, and antimicrobial drug or 8-50 μg / ml corticosteroid, and the antimicrobial drug is antifungal agent and / or antibacterial drug. The bioactive hyaluronic acid with anti-inflammatory effect in the preparation of the present invention replaces all or most of the corticosteroids, does not contain or only contains a small amount of corticosteroids, therefore, there is no or greatly reduces the effects of corticosteroids. side effect. In addition, bioactive hyaluronic acid with anti-inflammatory effects can be compounded with antifungal agents and / or antibacterial drugs to have antifungal and / or antibacterial effects at the same time, and can effectively treat gum, nasal mucosa, and skin diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an external compound preparation which can be used for treating inflammatory diseases of gums, nasal mucosa or skin. Background technique [0002] Inflammatory diseases of the gums, nasal mucosa, and skin occur frequently in China, and now most of them are treated with drugs containing corticosteroids, or corticosteroids, antibacterial drugs, and antifungal compound drugs. Commonly used corticosteroids such as triamcinolone acetonide. Because this type of drug has a certain curative effect, it is the main drug commonly used in treatment, but frequent use of effective doses of corticosteroids will cause systemic or local side effects. Therefore, the use of large doses of corticosteroids must be avoided. Therefore, for the above-mentioned diseases, it is urgent to develop a reliable pharmaceutical preparation with good curative effect, small side effects and curative effect equal to that of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/728A61P31/04A61P31/10A61P29/00A61P1/02A61P11/02A61P17/00A61K31/496A61K31/4164A61K31/58
Inventor 惠觅宙
Owner QINGDAO HUINUODE BIOLOGICAL TECH CO LTD
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