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Central pulse systole average normalization blood flow waveform model and method for obtaining aorta pulse wave transmission time based on same

A technology of central arterial and arterial blood flow, applied in the field of biomedical engineering, can solve the problems of inconsistency of waveform shape blood flow waveform and low amount of information, etc.

Active Publication Date: 2015-10-21
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, compared with the real central artery blood flow waveform, the central artery triangular blood flow waveform carries less information, and the waveform shape does not match the real blood flow waveform.

Method used

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  • Central pulse systole average normalization blood flow waveform model and method for obtaining aorta pulse wave transmission time based on same
  • Central pulse systole average normalization blood flow waveform model and method for obtaining aorta pulse wave transmission time based on same
  • Central pulse systole average normalization blood flow waveform model and method for obtaining aorta pulse wave transmission time based on same

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Experimental program
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Embodiment 1

[0059] In this embodiment, the central artery blood flow waveform is selected as the aortic blood flow waveform, and the corresponding central artery pressure waveform is selected as the aortic pressure waveform.

[0060] figure 1 In order to construct the flow chart of the average normalized blood flow waveform model of the aortic systole, the specific steps are as follows:

[0061] (a) Select m=100 healthy subjects to form a construction group, and use Doppler ultrasound equipment to collect aortic blood flow waveform Q at the supraclavicular fossa of each subject i (t), i=1, 2, ..., m, t is the time serial number of sampling point;

[0062] (b) Identify the aortic flow waveform Q for each subject in the construction group i The ejection end point ed of (t) i , and intercept the aortic blood flow waveform before the ejection end point, the aortic blood flow waveform before the ejection end point is the subject's aortic systolic blood flow waveform Q i (n), where 0≤n≤ed ...

Embodiment 2

[0101] In this embodiment, the carotid artery pressure waveform is obtained directly from the carotid artery, instead of using the generalized transfer function to construct the aortic pulse waveform from the radial artery pulse waveform; Aortic blood flow waveform used in Example 1.

[0102] Figure 9 Flowchart for constructing the average normalized blood flow waveform model of carotid artery systole. The specific steps are:

[0103] (a) Select m=100 healthy subjects to form a construction group, and use the Doppler ultrasound device to collect the carotid artery blood flow waveform Q at the carotid artery of each subject i (t), i=1, 2, ..., m, t is the time serial number of sampling point;

[0104] (b) Identify the carotid blood flow waveform Q of each subject in the construction group i The ejection end point ed of (t) i , and intercept the carotid artery blood flow waveform before the ejection end point, the carotid artery blood flow waveform before the ejection end ...

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Abstract

The invention provides a central pulse systole average normalization blood flow waveform model and a method for obtaining aorta pulse wave transmission time based on the same. The method comprises establishing a central pulse systole average normalization blood flow waveform model, and obtaining central pulse pressure waveform and central pulse blood waveform of a measured object based on the above model; and carrying out Fourier analysis on the central pulse pressure waveform and the central pulse blood waveform to calculate the characteristic impedance, and the calculating the aorta pulse wave transmission time (aoPTT). The central pulse blood waveform can be obtained without a blood flow detector by using the central pulse systole average normalization blood flow waveform model and the method for obtaining aorta pulse wave transmission time based on the same, so a method for obtaining the central pulse blood waveform can be simpler and safer. The central pulse blood waveform acquired using the model and the method is closer to human actual central pulse blood waveform, and the accuracy of calculation of aoPTT and the measurement of aoPWV can be raised.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a method for obtaining the transit time of aortic pulse wave based on the average normalized blood flow waveform model of central artery systole. Background technique [0002] Cardiovascular disease is the leading cause of death worldwide. According to the statistics of the World Heart Federation, one out of every three deaths worldwide is caused by cardiovascular disease, and the mortality rate of cardiovascular disease is much higher than that including Other diseases, including cancer and AIDS, have become the "number one killer" that threatens human health. "China Cardiovascular Report 2013" shows that there are 290 million patients with cardiovascular disease in my country, and 1 in every 5 adults suffers from cardiovascular disease. In my country, about 3.5 million people die from cardiovascular diseases every year, accounting for 41% of the total death caus...

Claims

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Application Information

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IPC IPC(8): A61B5/026A61B5/0285
CPCA61B8/06A61B8/5223
Inventor 叶骏张永亮杨剑胡福松何子军吴庆园吴漳洋马祖长孙怡宁
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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