A kind of nano-medicine with tumor therapeutic effect and preparation method thereof

A nano-drug and tumor treatment technology, applied in the field of drugs with tumor treatment effect, can solve problems such as the inability to completely overcome drug resistance, and achieve the effects of overcoming drug resistance, reducing toxic and side effects, and having a good therapeutic effect.
CN104983687BActive Publication Date: 2018-03-02SOUTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTHWEST UNIV
Publication Date
2018-03-02

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Abstract

The invention discloses a nano-medicine with tumor therapeutic effect and a preparation method thereof. It first loads doxorubicin with hollow mesoporous silica nanoparticles (HMSNs), and then treats it with bicarbonate to make a "nano bomb". When the drug enters the cell lysosome through endocytosis, the H+ in the lysosome can react with the drug and quickly generate CO2 gas; the generated gas destroys the integrity of the lysosome or improves the permeability of the lysosomal membrane Sex, induces lysosome-associated cell death, thereby killing cancer cells. The "nanometer bomb" also has a good therapeutic effect on drug-resistant strains, and can effectively overcome the drug resistance of cancer cells.
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Description

technical field

[0001] The present invention relates to a kind of medicament with function of treating tumor. Background technique

[0002] According to the report of the International Agency for Research on Cancer (IARC), by 2030, there will be 21.4 million new cancer patients worldwide, and at the same time, 13.2 million new cancer patients will also die (Document 1: Allen T M, Cullis P R. Science, 2004 , 303(5665):1818-1822).

[0003] Chemotherapy, referred to as chemotherapy, is one of the three major means of treating cancer, but the emergence of toxic side effects and multi-drug resistance of cancer cells has limited its application (Document 2: Luqmani Y A. Medical principles and practice: international journal of the Kuwait University, Health Science Centre, 2004, 14:35-48).

[0004] A variety of methods have been used to solve the drug resistance of cancer cells, such as mitochondria-targeted photodynamic therapy (Document 3: Han K, Lei Q, Wang S B, et al. Advance...

Claims

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