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Medical application of notoginsenoside ST-4

A technology of ST-4 and notoginseng saponin, applied in the field of medical application of notoginseng saponin ST-4, can solve problems such as poor blood sugar control, affecting wound healing, and reduced ability to eliminate bacteria

Active Publication Date: 2015-11-04
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the blood sugar control of diabetic patients is not good, and the body's ability to eliminate bacteria will be reduced
High blood sugar can reduce the ability of cells to transport oxygen to tissues, resulting in poor blood circulation and affecting wound healing

Method used

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  • Medical application of notoginsenoside ST-4
  • Medical application of notoginsenoside ST-4
  • Medical application of notoginsenoside ST-4

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Experimental program
Comparison scheme
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specific Embodiment approach

[0036] 1. Experimental materials

[0037] 1.1 Herbs

[0038] Notoginsenoside ST-4 (molecular weight: 917.13, HPLC purity ≥ 99%, Institute of Chinese Materia Medica)

[0039] 1.2 Experimental animals

[0040] db / db female mice (12 weeks) weighing 50±5 g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal certificate number: SCXK (Shanghai) 2012-0002. Placed in a conventional feeding environment, housed in separate cages, free to eat and drink.

[0041] 2. Experimental method

[0042] 2.1 Establishment of diabetes injury model

[0043] Using the modeling method in the literature (Nature Protocols, 2013, 8: 302-309), after isoflurane anesthesia, the back skin was shaved, depilatory cream was removed, and routine skin disinfection was performed. A circular incision is made on both sides, reaching deep to the fascia. In order to prevent the wound from shrinking automatically, silicone gaskets (0.5mm thick, inner diame...

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Abstract

The invention relates to the field of medicine science, in particular to the medical application of notoginsenoside ST-4. According to the medical application disclosed by the invention, an animal experiment verifies that wound healing of diabetes can be effectively promoted by the notoginsenoside ST-4, and great significance on the treatment of diabetic gangrene is obtained.

Description

technical field [0001] The invention relates to the field of medicine and health care products, in particular to the medical use of notoginseng saponin ST-4. Background technique [0002] Diabetes is a metabolic disease that seriously threatens human health, and has become the fourth leading cause of death after cardiovascular, tumor and AIDS. Statistics show that there are currently 285 million diabetic patients in the world, and it is predicted that by 2030, the number of diabetic patients in the world will reach 439 million, and the complications caused by diabetes have become the main cause of disability and death of patients. Among the many complications of diabetes, the impaired wound healing ability of diabetic patients is a typical complication of diabetes. If chronic injuries and ulcers occur in the feet, it may cause diabetic foot, and even lead to amputation in severe cases. Diabetes is the disease with the highest hospitalization rate, and it is reported that th...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K8/63A61Q11/00A61P17/02A61P7/04A61P3/10A23L1/29A23L33/00
Inventor 王峥涛张二云王如锋高波刘青吴晓俊杨莉
Owner SHANGHAI UNIV OF T C M
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