Application of Akkermansia muciniphila BAA-835 strain

A technology of strains and drugs, applied in the application field of probiotics, can solve the problem of no long-term effective treatment method, achieve the effect of effective blood sugar control and broaden the application field

Inactive Publication Date: 2015-11-11
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Application Information

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Problems solved by technology

At present, there is no long-term effective treatment for diabetes, except for the tr

Method used

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  • Application of Akkermansia muciniphila BAA-835 strain
  • Application of Akkermansia muciniphila BAA-835 strain
  • Application of Akkermansia muciniphila BAA-835 strain

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[0019] Example 1

[0020] C57 / BL6 male SPF mice were randomly divided into a control group and a perfusion group, each with 8-10 mice. The control group was given sterile PBS gavage once a day; the perfusion group was given Akkermansiamuciniphila BAA-835 strain suspension according to 2*10 9 cfu / mouse, perform gastric gavage test once a day. Test for 5 weeks. After the test, the glucose tolerance of mice was tested.

[0021] The specific glucose tolerance situation is shown in Table 1 below.

[0022] Table 1

[0023]

[0024]

[0025] It can be seen from the table that after gavage of Akkermansiamuciniphila BAA-835 strain suspension to mice, the glucose tolerance increased significantly slower than that of mice in the control group, indicating that Akkermansiamuciniphila BAA-835 strain is very effective in controlling blood sugar. Specific as figure 1 with figure 2 Shown.

[0026] The area under the glucose tolerance curve of mice was calculated, as shown in Table 2:

[0027] Table...

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Abstract

The invention belongs to the field of probiotic application and particularly relates to application of an Akkermansia muciniphila BAA-835 strain in preparation for treating or preventing diabetes mellitus. According to the application, controlled experiments on C57/BL6 male SPF mouse littermates which are randomly divided into a control group and a strain gavage group are adopted, an Akkermansia muciniphila BAA-835 strain suspension gavage test is given to the strain gavage group once a day for 5 weeks. By means of the tests, the glucose tolerance area under the curve of the strain gavage group is reduced by 21.3 percent in comparison with that of the control group, which verifies that the Akkermansia muciniphila BAA-835 strain has an effect of improving glycometabolism and can be applied to the field of treatment or prevention of diabetes mellitus.

Description

technical field [0001] The invention belongs to the application field of probiotics, in particular to the application of Akkermansiamuciniphila BAA-835 bacterial strain in treating or preventing diabetes. Background technique [0002] Due to the changes in the lifestyle and diet structure of modern people, the incidence of diabetes is increasing day by day. As a risk factor for cardiovascular events and tumors, diabetes has become a global social health problem. At present, there is no long-term effective treatment for diabetes, except for the traditional five carriages and the application of insulin in the late stage of diabetes. Since the 2004 GORDON laboratory proposed that intestinal flora can regulate lipid metabolism as an environmental factor, research on the correlation between intestinal flora and obesity and diabetes has emerged in an endless stream in recent years. In 2012, Shenzhen Huada used the next-generation sequencing technology based on shotgun sequencing...

Claims

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Application Information

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IPC IPC(8): A61K35/741A23K1/16A23L1/29A61P3/10
Inventor 宁光王计秋洪洁王卫庆刘瑞欣赵少倩刘文石娟
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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