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Preparation method for acidity-controllable drug carrier

A drug and carrier technology, applied in the field of drug carrier preparation, can solve the problems of side effects, leakage of sensitive tissues, liposome instability, etc., and achieve the effect of no cytotoxicity, low cost and simple operation

Active Publication Date: 2015-11-11
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to solve the problem that when the existing liposome is used as a drug carrier, the liposome is unstable in the human body and is easily broken to cause internal drug leakage, which has side effects on sensitive tissues

Method used

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  • Preparation method for acidity-controllable drug carrier
  • Preparation method for acidity-controllable drug carrier
  • Preparation method for acidity-controllable drug carrier

Examples

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specific Embodiment approach 1

[0016] Embodiment 1: The preparation method of a drug carrier with controllable acidity described in this embodiment is specifically carried out according to the following steps:

[0017] 1. ITO surface cleaning: first clean two pieces of ITO glass electrodes with absolute ethanol for 15min-20min, then use distilled water for ultrasonic cleaning for 15min-20min, and then dry them with nitrogen to obtain two pieces of cleaned ITO glass electrodes;

[0018] 2. Preparation of vesicle solution: Add palmitoyl oleoyl phosphatidylcholine to chloroform to obtain a phospholipid solution with a concentration of 5 mg / mL, and coat the surfaces of two cleaned ITO glass electrodes with 5 μL to 7 μL of 5 mg / mL of the phospholipid solution, after the chloroform volatilizes, two ITO glass electrodes covered with phospholipids are obtained, the polytetrafluoroethylene rectangular frame is placed in the middle of the two ITO glass electrodes covered with phospholipids on the surface, and the ele...

specific Embodiment approach 2

[0024] Embodiment 2: This embodiment differs from Embodiment 1 in that the water-soluble drug described in step 2 is an aqueous solution of 5-fluorouracil. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0025] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the concentration of the aqueous solution of 5-fluorouracil is 0.15 μmol / L˜77 μmol / L. Others are the same as in the first or second embodiment.

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Abstract

The invention relates to a preparation method for a drug carrier, in particular to a preparation method for an acidity-controllable drug carrier. The problems that when existing lipidosome is used as a drug carrier, the lipidosome is unstable in a human body and is prone to breaking, internal drug leaks, and consequently a side effect is caused to sensitive tissue; meanwhile, not all the lipidosome can be used as the carrier of acidity-controllable slow release drugs, and limitation exists are solved. The preparation method comprises the steps that 1, ITO surface cleaning is carried out; 2, a vesicle solution is prepared; 3, a phospholipid vesicle-poly-dopamine complex is prepared. The preparation method is used for preparing the acidity-controllable drug carrier.

Description

technical field [0001] The invention relates to a preparation method of a drug carrier. Background technique [0002] At present, there have been some reports on liposome as a drug carrier at home and abroad, but it is undeniable that the defect of liposome as a drug carrier is that liposome is unstable in the human body, and it is easy to break and cause internal drug leakage, which has side effects on sensitive tissues. . The environment near cancer cells is a neutral acidic environment, so it is very important to prepare an anticancer drug carrier with acid control properties. Although some liposomes are composed of acid-sensitive phospholipids, not all liposomes are suitable as acid-sensitive phospholipids. Carriers for controlled and sustained-release drugs have limitations. Contents of the invention [0003] The present invention solves the problem that when the existing liposome is used as a drug carrier, the liposome is unstable in the human body and is easily br...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/24A61K9/127A61P35/00C25B3/00
Inventor 韩晓军宗薇
Owner HARBIN INST OF TECH
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