Diagnosis marker suitable for esophagus cancer early-stage diagnosis

A diagnostic marker and early diagnosis technology, applied in the field of food, can solve the problems of inability to achieve early diagnosis of esophageal cancer, high sensitivity of advanced esophageal cancer, and complicated diagnostic operations, and achieve a simple diagnosis process, reduce pain, and reduce mortality. Effect

Active Publication Date: 2015-11-11
SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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Problems solved by technology

[0007] For the diagnosis of esophageal cancer (also known as esophageal squamous cell carcinoma) in the prior art is complicated, expensive, and invasive, the current markers are only highly sensitive to advanced esophageal cancer, and cannot achieve early diagnosis of esophageal cancer, etc. Insufficient, the present invention provides a kind of diagnostic marker that is suitable for the early diagnosis...

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  • Diagnosis marker suitable for esophagus cancer early-stage diagnosis
  • Diagnosis marker suitable for esophagus cancer early-stage diagnosis
  • Diagnosis marker suitable for esophagus cancer early-stage diagnosis

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Embodiment Construction

[0070] Below, the present invention is further explained through the following specific embodiments, and the advantages of the present invention are further proved.

[0071] The screening of the diagnostic markers of the present invention, the construction method of the diagnostic model and the effect verification are as follows:

[0072] 1. Research object

[0073] Relying on the esophageal cancer screening platform of "National Demonstration Base for Early Diagnosis and Treatment of Esophageal Cancer (Feicheng City, Shandong Province)", this study targeted iodine-stained biopsy subjects aged 40-69 under gastroscope in Feicheng City, Shandong Province (confirmed as the gold standard) Collect esophageal carcinoma in situ (39 cases at stage 0), early esophageal cancer (17 cases at stage I, 11 cases at stage II) and advanced esophageal cancer (30 cases at stage III); The test subjects were 105 healthy subjects without upper gastrointestinal lesions as healthy samples.

[0074]...

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Abstract

The invention discloses a diagnosis marker suitable for an esophagus cancer early-stage diagnosis. The diagnosis marker is a combination of two or more than two kinds of materials from the following seven kinds of serum metabolic markers including LPA (lysophosphatidic acid) [18 to 1(9Z)/0 to 0], LysoPC (lysolecithin) (14 to 0/0 to 0), LysoPC (lysolecithin) [18 to 2(9Z,12Z)], LysoPC (lysolecithin) (24 to 0), phospholipids PC [14 to 1(9Z)/P-18 to 1(11Z)], phospholipids PC [16 to 0/18 to 2(9Z,12Z)] and phospholipids PC [24 to 1(15Z)/22 to 6(4Z,7Z,10Z,13Z,16Z,19Z)]. When the diagnosis marker provided by the invention is adopted, a diagnosis model can be built. The diagnosis model has the advantages of good effect, high sensitivity and good specificity, is suitable for late-stage and early-stage esophagus cancer diagnoses, and has good clinic use and popularization value.

Description

technical field [0001] The present invention relates to the diagnosis of esophageal cancer, in particular to a diagnostic marker for esophageal cancer, a screening method for the diagnostic marker, a diagnostic model constructed on the basis of the diagnostic marker, and a method for constructing the diagnostic model, the diagnostic marker and the diagnosis method. The model has good diagnostic effect on esophageal carcinoma in situ, early and advanced esophageal cancer, is particularly suitable for early diagnosis of esophageal cancer, and belongs to the technical field of esophageal cancer diagnosis. Background technique [0002] Esophageal cancer is a malignant lesion formed by abnormal proliferation of esophageal squamous epithelium or glandular epithelium. According to the latest data from the World Health Organization, about 400,000 people die from esophageal cancer every year in the world. my country is the country with the highest incidence and mortality rate of esop...

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Application Information

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IPC IPC(8): G01N33/574
CPCG01N33/57446
Inventor 王家林张涛朱正江薛付忠赵德利于金明
Owner SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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