Application of chenodeoxycholic acid as active constituent to preparing medicine for treating echinococcosis granulosa

Abstract

The invention discloses application of chenodeoxycholic acid as an active constituent to preparing medicine for treating echinococcosis granulosa. The application has the advantages that pathogen-echinococcosis granulosus tapeworms of the echinococcosis granulosa can be killed by the chenodeoxycholic acid, obvious echinococcosis granulosus protoscolex inhibiting and killing effects can be realized, and accordingly theechinococcosis granulosa can be treated.

Description

technical field [0001] The invention relates to the pharmaceutical application of chenodeoxycholic acid and belongs to the field of medicinal chemistry. Background technique [0002] Echinococcus granulosus (Echinococcus granulosus, Eg), also known as cystic echinococcosis (CE), is a serious threat to people's health and Zoonotic parasitic diseases of livestock development. The disease is distributed globally and is mainly prevalent in Xinjiang, Qinghai, Inner Mongolia, Tibet and other provinces with developed animal husbandry in my country. Cystic echinococcosis primarily affects the liver, but can also develop in the lungs. At present, the treatment for this disease is mainly a surgical method, that is, complete resection of the outer and outer capsules of the hepatic hydatid adventitia. Although the complete excision of the outer and outer capsules of the hepatic hydatid cysts adopted in recent years can greatly reduce the recurrence rate of echinococcosis and minimize...

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Problems solved by technology

Therefore, on the whole, extravasation of the scoliosis and improper handling of the scoliosis during surgery are insurmountable defects in the surgical treatment of cystic echinococcosis.

[0003] For the problems referred to above, this area attempts to adopt high-concentration acidic (HCl) and alkaline solution (KOH) in vitro, and the local chemotherapeutic drug commonly used in clinic has 20% hypertonic saline, but has certain destructive effect to surrounding normal liver tissue; Studies in the field have also found that bile can inhibit the development of hydatid cysts, but bile has complex components, multiple targets, and variable pharmaceutical effects. For example, the retention of bile and bile acids in the liver and blood will produce a variety of toxic effects, including cytotoxicity. The effects of acute and chronic toxicity can cause liver damage and systemic multi-system and multi-organ damage, and eventually lead to liver cirrhosis, liver failure and death; studies have also found that bile acids can cause damage to pancreatic acinar cells, etc.

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