Preparation process of deoxycholeic acid of bear

A technology of ursodeoxycholic acid and chenodeoxycholic acid, which is applied in the field of artificial synthesis of bear bile, can solve the problems of limited sources of bear bile, inability to meet medical needs, and many processing steps

Inactive Publication Date: 2008-10-22
SHANDONG AOCTER CHEM
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Problems solved by technology

In the past, bile was extracted from bear bile to make ursodeoxycholic acid. However, live bears are protected by the animal protection law, and the source of bear bile is limited. At the same time, the processing process has many steps, long cycle time, and low production rate, which cannot meet medical needs.

Method used

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  • Preparation process of deoxycholeic acid of bear
  • Preparation process of deoxycholeic acid of bear
  • Preparation process of deoxycholeic acid of bear

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Embodiment Construction

[0012] The specific embodiments of the present invention will be further described below in conjunction with the accompanying drawings.

[0013] refer to figure 1 , the preparation process of ursodeoxycholic acid comprises: oxidation process A, hydrogenation process B, purification process C. Add chenodeoxycholic acid 1, solvent I 2, and oxidizing agent 3 during oxidation process A, and precipitate solvent I 2 through reaction to form intermediate 4. Enter hydrogenation process B process, mix solvent II 5 and intermediate 4, Add catalyst 6, add nitrogen gas 7 for gas protection during this process, then add hydrogen gas 8 to replace nitrogen gas 7, and combine reaction to generate crude ursodeoxycholic acid 9. Then the purification process C is carried out, the crude ursodeoxycholic acid 9 is completely dissolved with the solvent III 10, and then the purifying agent 11 is added, and the finished ursodeoxycholic acid 12 is produced through a compound reaction. The specific co...

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Abstract

A preparation method for ursodeoxycholic acid regards chenodeoxycholic acid (1) as raw materials; in technological processes, after adopting corresponding equipment and adding excipient according to the proportional variety and dosage, chemical reactions are carried out through the process flow of an oxidation process (A), a hydrogenation process (B), and a purification process (C) in particular temperature and environmental conditions. In the oxidation process (A), an oxidant (3) and a solvent I 2 are added for oxidation reaction to generate an intermediate (4); in the hydrogenation process (B), a catalyst (6) and a solvent II(5) are added for hydrogenation reaction to get ursodeoxycholic acid crude products (9); in the purification process (C), a passivating agent (11) and a solvent III (10) are added for producing the products of ursodeoxycholic acid (12). The process route of the invention is reasonable; the chemical reactions are mild and safe; the operating conditions are easy to be controlled; the yield is high and the invention makes great progress in the research and production of artificially synthesizing ursodeoxycholic acid (12).

Description

technical field [0001] The invention relates to a famous and precious traditional Chinese medicine bear bile, in particular to an artificial synthesis method of bear bile. Background technique [0002] Bear bile is a traditional precious medicinal material. As the main active ingredient contained in bear bile, ursodeoxycholic acid has a strong effect of promoting the hydrolysis of fat and fatty acid. It is mainly used clinically to treat various liver and gallbladder diseases and digestive tract diseases. Diseases, such as intrahepatic cholestasis of pregnancy, gallbladder fibrosis liver disease, alcoholic liver disease, fatty liver, gallstones, viral hepatitis, etc., all have good curative effects. New research shows that ursodeoxycholic acid not only has good curative effect in the treatment of primary biliary cirrhosis, primary sclerosing cholangitis, chronic active hepatitis, etc., but also can be used in the treatment of chronic hepatitis and liver transplantation reje...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00
CPCY02P20/584
Inventor 曹俊山郝秀利潘维民王淑华刘俊红
Owner SHANDONG AOCTER CHEM
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