Preparation process of deoxycholeic acid of bear

A technology of ursodeoxycholic acid and chenodeoxycholic acid, which is applied in the field of artificial synthesis of bear bile, can solve the problems of limited sources of bear bile, inability to meet medical needs, and many processing steps
CN101289488AInactive Publication Date: 2008-10-22SHANDONG AOCTER CHEM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG AOCTER CHEM
Publication Date
2008-10-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

A preparation method for ursodeoxycholic acid regards chenodeoxycholic acid (1) as raw materials; in technological processes, after adopting corresponding equipment and adding excipient according to the proportional variety and dosage, chemical reactions are carried out through the process flow of an oxidation process (A), a hydrogenation process (B), and a purification process (C) in particular temperature and environmental conditions. In the oxidation process (A), an oxidant (3) and a solvent I 2 are added for oxidation reaction to generate an intermediate (4); in the hydrogenation process (B), a catalyst (6) and a solvent II(5) are added for hydrogenation reaction to get ursodeoxycholic acid crude products (9); in the purification process (C), a passivating agent (11) and a solvent III (10) are added for producing the products of ursodeoxycholic acid (12). The process route of the invention is reasonable; the chemical reactions are mild and safe; the operating conditions are easy to be controlled; the yield is high and the invention makes great progress in the research and production of artificially synthesizing ursodeoxycholic acid (12).
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Description

technical field

[0001] The invention relates to a famous and precious traditional Chinese medicine bear bile, in particular to an artificial synthesis method of bear bile. Background technique

[0002] Bear bile is a traditional precious medicinal material. As the main active ingredient contained in bear bile, ursodeoxycholic acid has a strong effect of promoting the hydrolysis of fat and fatty acid. It is mainly used clinically to treat various liver and gallbladder diseases and digestive tract diseases. Diseases, such as intrahepatic cholestasis of pregnancy, gallbladder fibrosis liver disease, alcoholic liver disease, fatty liver, gallstones, viral hepatitis, etc., all have good curative effects. New research shows that ursodeoxycholic acid not only has good curative effect in the treatment of primary biliary cirrhosis, primary sclerosing cholangitis, chronic active hepatitis, etc., but also can be used in the treatment of chronic hepatitis and liver transplantation reje...

Claims

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