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Selection method of solid phase extraction packing

A solid-phase extraction column and extraction technology, applied in the field of analytical chemistry, can solve problems such as inaccuracy and fuzzy evaluation of compound properties

Active Publication Date: 2017-11-07
SHANDONG WATER & WASTEWATER MONITORING CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the fuzzy and inaccurate evaluation of compound properties during the development of the SPE method, the present invention provides a set of methods suitable for compound property evaluation and filler optimization in the SPE application process based on SPE fillers

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  • Selection method of solid phase extraction packing
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  • Selection method of solid phase extraction packing

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Experimental program
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Embodiment 1

[0036] Development of solid-phase extraction enrichment method for 2-chlorophenol, 2,4-dichlorophenol and 2,4,6-trichlorophenol in water quality. Applying the property evaluation method of this compound, the TPSA value of the three chlorophenol compounds is 20.2, and the number of carbon atoms is 6, so the calculation of TPSA / n cThe value is 3.37, which is a medium polar compound. After inquiry, 2-chlorophenol log (KOW) = 2.15, 2,4-dichlorophenol log (KOW) = 2.87, 2,4,6-trichlorophenol log (KOW) = 3.63, all three are insoluble in water substance. Therefore, after evaluating according to Table 2, HLB and its equivalent PEP column or PS column should be selected for the solid phase extraction of the three compounds.

[0037] Using tetrahydrofuran as the elution solvent and HLB column as the extraction column, the SPE recoveries of the three chlorophenols are shown in Table 3. Experiments show that the HLB column directly selected after the evaluation of this method has a good...

Embodiment 2

[0042] The development of SPE extraction enrichment method for four kinds of HCH in water quality. Select α-666, β-666, γ-666, and δ-666 as the experimental objects. After evaluation by this method, the TPSA / n of the four 666 c The value is 0, all of which are non-polar substances, and the range of log(KOW) is between 3.78-3.83, which is poorly soluble in water. After evaluation by the methods in Table 2, non-polar extraction columns such as C18 should be selected.

[0043] In the experiment, dichloromethane is used as the eluting solvent, C18 is selected as the experimental column, and HLB and PEP are selected as the contrast column by the two general-purpose columns excluded by this method. The recovery rates of four kinds of HHC are as follows: figure 1 shown. Experiments show that the C18 column optimized by this method has a good recovery rate for the four kinds of HCH. At the same time, in the control column experiment excluded by this method, the recovery rate is muc...

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Abstract

The invention discloses a selecting method for solid-phase extraction packing, and the method is applied to the development process of an SPE method. A compound property assessment method comprises compound polarity assessment and compound solubility assessment; compound polarity assessment divides compounds into four classes by taking per unit carbon atom polar molecular surface area TPSA / nc as the index; the compound solubility assessment divides the compound into water-soluble substances and water-insoluble substances by taking an octanol / water partition coefficient log(Kow) as the index; a solid-phase extraction column is selected according to a compound polarity assessment result and a compound solubility assessment result. According to the selecting method for the solid-phase extraction packing, after the polarity and solubility of the compounds are assessed, the SPE column is preferably selected according to the assessment results, and the preferably selected SPE column can well meet the experimental requirements.

Description

technical field [0001] The invention relates to a compound analysis method, which is applied in the process of solid phase extraction packing optimization and method development, and belongs to the field of analytical chemistry. Background technique [0002] Solid-phase extraction (Solid-phase extraction, SPE) is a widely used sample pretreatment method, which is suitable for the separation and extraction of analytes in gas, liquid and other mobile phases. SPE separates and extracts the analyte according to the selective distribution between the solid-phase adsorption filler and the sample mobile phase. The analyte must have a better distribution coefficient in the filler to achieve the retention and adsorption of the substance. [0003] At the beginning of the development of SPE, it was used as a supplement to the traditional liquid-liquid extraction method. Now, with its outstanding advantages: strong selectivity, short separation time, less use of organic solvents, and go...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F19/00B01D15/20
Inventor 贾瑞宝王永朝孙韶华王明泉
Owner SHANDONG WATER & WASTEWATER MONITORING CENT