Tamponade method of card bottle and device of tamponade method

Abstract

The invention discloses a tamponade method of a card bottle and a device of the tamponade method, and belongs to the technical field of card bottle freeze-drying and card bottle subpackaging / filling. According to the tamponade method of the card bottle disclosed by the invention, an interspace is produced between a rubber plug and inner walls of a card bottle as a gas passage in the process of tamponade. The tamponade device of the card bottle disclosed by the invention comprises a piston rod used for tamponade, and a separation device, wherein the separation device enables that the rubber plug and the inner walls of the card bottle are partly or wholly separated in the process of tamponade so that the gas passage is produced. According to the tamponade method disclosed by the invention, a plug stuffing movement of a reagent in the card bottle can be completed in the process of freeze-drying, and the preparation of needle preparations of freeze-dried powder of the card bottle can be realized; the traditional filling technology of the squirt cut preparations and the subpackaging technology of needle preparations of sterile powder of the card bottle are changed; the problems that the conventional technology process is miscellaneous and the consistency is difficult to guarantee are solved; the tamponade device of the card bottle is convenient to operate and simple in structure; the conventional equipment is easy to reform, so that the automatic production of the tamponade device of the card bottle is convenient to popularize.

Description

technical field [0001] The invention relates to the technical field of cartridge freeze-drying and cartridge subpackaging / filling, in particular to a cartridge corking method and device. Background technique [0002] Cartridge bottle, also known as borosilicate glass sleeve for pen-type syringe, is the container inside the pen-type syringe for containing water or powder injection preparations. A cartridge is similar to a syringe without a plunger, which is equivalent to a "bottomless bottle". The head of the bottle is equipped with an injection needle protected by a rubber seal, the mouth of the bottle is sealed with a rubber stopper and an aluminum cover, and the tail is sealed with a rubber piston. The cartridge is placed in a reusable cartridge injection rack or injection pen for use, and the liquid medicine does not come into contact with any part of the syringe during use. [0003] At present, the filling and dispensing process of cartridge preparations (including car...

AI Technical Summary

Problems solved by technology

Conversely, if the process is changed to capping→filling / dispensing medicine→adding piston, since the internal and external pressure of the cartridge bottle is the same during the stoppering process, the pressure inside the bottle after stoppering is greater than the pressure outside the bottle, and the rubber stopper is affected by the pressure difference between the inside and outside of the bottle. The effect will be ejected from the bottle, making the stoppering process impossible

[0004] At the same time, it is also impossible to stopper the cartridges in the freeze-drying process by using the above method

On the contrary, if the lyophilized cartridge is stoppered in a vacuum environment, although the stoppering process can be completed, when the stoppered cartridge is repressurized, the external pressure of the cartridge is greater than the internal pressure of the cartridge. , at this time, the rubber stopper will be directly pressed to the deepest part of the cartridge under the action of the pressure difference, and destroy the drug in the cartridge

Therefore, it is precisely because there is currently no stoppering method for cartridges that the freeze-dried powder preparations for cartridges cannot be achieved.

In addition, in the traditional cartridge filling process, the filling volume of the water injection preparation is determined by the stroke of the piston in the cartridge, and the inconsistency and instability of the piston position during the filling process directly leads to the inconsistency of the filling volume sex

In order to further ensure the consistency of the filling volume, the process of filling the liquid medicine needs to be divided into one filling and two supplementary fillings. The consistency of the filling volume is difficult to guarantee, and the filling process is cumbersome.

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