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Silicone gel adhesive with hydrophilic and antimicrobial properties

An antimicrobial, adhesive technology, used in adhesives, surgical adhesives, bandages, etc., to solve problems such as discomfort, patient discomfort, and reduced bond strength

Active Publication Date: 2017-10-13
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some properties of PSA limit its application to adhere to skin
For example, a PSA with an excessively high degree of adhesive strength can cause skin damage when removed
Alternatively, if the bond strength is reduced, the PSA may lack sufficient holding power to be useful, or will lose sufficient tack for room temperature use
Additionally, PSAs that are relatively rigid or conformable compared to skin often cause significant patient discomfort during use
Furthermore, even adhesives with low measured peel adhesion to skin can cause discomfort when removed, for example if the adhesive becomes tangled with hair

Method used

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  • Silicone gel adhesive with hydrophilic and antimicrobial properties
  • Silicone gel adhesive with hydrophilic and antimicrobial properties
  • Silicone gel adhesive with hydrophilic and antimicrobial properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1: a kind of adhesive composition, adhesive composition comprises:

[0062] a) silicone gel, said silicone gel comprising 1 )(R 2 ) 2 The cross-linked poly(diorganosiloxane) of the terminal group, wherein R 1 is hydroxy, alkyl or aryl, and each R 2 are independently alkyl or aryl;

[0063] b) a hydrophilic component dispersed in the silicone gel, wherein the hydrophilic component comprises carbohydrates having at least 3 hydroxyl groups, carbohydrate derivatives having at least 3 hydroxyl groups , or a combination of them; and

[0064] c) an antimicrobial agent dispersed in the silicone gel, wherein the antimicrobial agent comprises elemental copper, elemental silver, copper-containing compounds, silver-containing compounds, or combinations thereof;

[0065] wherein less than 10% by weight of the hydrophilic component is extractable from the adhesive composition into a phosphate buffered saline solution having a pH of 7 within 24 hours at room temperatu...

Embodiment 2

[0066] Embodiment 2: The adhesive composition of embodiment 1, wherein the silicone gel is crosslinked in the absence of a peroxide, condensation catalyst, or hydrosilylation catalyst.

Embodiment 3

[0067] Embodiment 3: The adhesive composition of any one of embodiments 1 or 2, wherein the silicone gel is substantially free of -SiH groups.

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Abstract

The present invention provides an adhesive composition comprising a cross-linked silicone gel, a hydrophilic component dispersed in the silicone gel, and an anti-aging component dispersed in the silicone gel. Microbial agent. The adhesive composition is easy to apply to the skin (and easy to remove), and has the desired hydrophilic and antimicrobial properties. Advantageously, the hydrophilic components of the cross-linked silicone gel are not easily extracted (eg, in a pH 7 buffer). Surprisingly, the combination of a hydrophilic component and an antimicrobial agent in the crosslinked silicone gel can provide a synergistically enhanced level of antimicrobial activity.

Description

technical field [0001] The present disclosure relates to hydrophilic silicone gel adhesives, and more particularly, to crosslinked hydrophilic silicone gel adhesives by comprising Manufactured by electron beam or gamma ray curing methods. Background technique [0002] Application of pressure sensitive adhesives (PSAs) (including silicone pressure sensitive adhesives) to adhere skin is known in the art and many examples of pressure sensitive adhesives are commercially available. However, some properties of PSA limit its application to adhere to skin. For example, a PSA with an excessively high degree of adhesive strength can cause skin damage when removed. Alternatively, if the bond strength is reduced, the PSA may lack sufficient holding power to be useful, or will lose sufficient tack for use at room temperature. Additionally, PSAs that are relatively rigid or conformable compared to skin often cause significant discomfort to the patient during use. Furthermore, even ad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09J183/04
CPCC09J183/04A61L31/06A61L31/16A61L15/46A61L15/58A61L24/0015A61L24/046A61L2300/102A61L2300/104A61L2300/404C08L9/02C08K5/101C08L83/04C09J183/02
Inventor M·D·德特曼谢乔远J·查特杰
Owner 3M INNOVATIVE PROPERTIES CO