Compositions and methods for treating surface wounds

A composition and trauma technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of dangerous complications, slow healing, difficult healing, etc.

Inactive Publication Date: 2015-12-09
波利斯格林施泰恩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the medical community dismisses that efficacy as marginal and unsatisfactory at best
[0022] As shown for burns, decubitus ulcers and diabetic ulcers, localized wounds are still common, difficult to heal, slow to heal, and dangerous in their complications

Method used

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  • Compositions and methods for treating surface wounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0154] Example 1: Exemplary preparation of reconstituted extract composition:

[0155] The following is an exemplary embodiment of the composition of the present invention, in which a single plant extract is reconstituted in a fluid to be combined with other ingredients. The upper end of the range that can be used for the weight% incorporation of the extract is largely determined by its solubility; the lower end is determined by the potency of the concentration. The selection of the organic solvent and the ratio of the liquid components are also variable, and may depend, for example, on whether the anticorrosive effect is desired from the solvent. The specific formulations shown in the following table have been found to be particularly useful, but the present invention is not limited thereto.

[0156] Dry ingredients

[0157] Liquid ingredients

Embodiment 2A

[0158] Example 2A: Exemplary preparation of liquid and gel compositions

[0159] The following is an exemplary embodiment of the composition of the present invention. The upper end of the range of weight% incorporation that can be used for each extract is largely determined by its solubility; the lower end is determined by the potency of the concentration. The choice of organic solvent and the ratio of liquid components are also variable. The specific formulations shown in the following table have been found to be particularly useful, but the present invention is not limited thereto.

[0160]

[0161] Liquid ingredients

Volume basis

Hydrogen peroxide (optional)

1 liter (3%H 2 O 2 ,97% water, by weight)

Ethanol (optional)

1 liter (90% EtOH, 10% H 2 O)

Water (purified)

Bring the total volume of the composition to 4 gallons

[0162] The standardized dry extract was obtained from NatureX (375 Huyler St., South Hackensack, NJ07606 (201) 440-5000) in pharmaceutical grade,...

Embodiment 2B

[0165] Example 2B: Exemplary preparation of the emulsion composition of the present invention:

[0166] 30g of a mixture of three dry extracts with the same species identity shown in Example 2A and a dry mass ratio of about 1:1:1 was combined with 4kg of Medica’s Versapro TM The emulsion base (which is further supplemented with 0.5% by weight of allantoin) is mixed and dissolved therein. In this case, the emulsion base also contains aloe extract.

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Abstract

The invention provides synergistic compositions and methods to prevent and treat dermal wounds and topical ulcers rapidly, efficaciously and economically. It comprises a synergistic combination of natural products, specifically the combination of an extract of Hydrastis canadensis, an extract of a species of the genus Panax and an extract of a Aloe barabadensis L. that are essentially free of extract of Passiflora incarnata L. The combination can be administered to wounded skin and or a wound topical cavity of a patient as a prophylactic or therapeutic dose, and may optionally be delivered by means of a wetted dressing. The invention further provides kits that may be used for topical application of the combination.

Description

[0001] Federal grants [0002] No funds from federal resources were used in the development of this invention. Invention field [0003] The invention belongs to a composition and a method for healing local wounds and preventing their formation. Background of the invention [0004] Fleshwounds are widespread but mistakenly considered trivial. Currently, for 75% of otherwise healthy individuals, moderate bedsores (i.e. stage II) require 8 weeks of careful care. For stage IV sores (the most advanced stage), 38% never heal; the remaining part usually requires at least 1 year of care. D.R. Thomas et al., J. Am. Med. Dir. Assoc., 6(1): 46-49 (2005). Pressuresores are common: the incidence is 0.4-38% in short-term care, 2.2-23.9% in long-term care, and 29% in home care. NPUAP Board of Directors, "Pressure ulcers in America: prevalence, incidence, and implications for the future," in An Executive Summary of the NPUAP Monograph, ed. Cuddigan, J., etc., (Jul / August 2001). In fact, at the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P17/00A61K36/71A61K36/258A61K36/886
CPCA61K45/06A61K31/21A61K31/4166A61K31/7008A61K31/7036A61K31/728A61K33/40A61K36/258A61K36/71A61K36/886A61K38/39A61P17/00A61P17/02A61P31/04A61P43/00A61K2300/00
Inventor 波利斯.格林施泰恩
Owner 波利斯格林施泰恩
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