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Total ziyuglycoside extract and preparation method and application thereof

A technology of saponins and extracts of Burnet burnet, applied in the field of total saponins of Burnet burnet and its preparation, can solve the problems of large loss of total saponins of Burnet burnet, unfavorable industrial production, cumbersome steps, etc., achieve low production cost, increase content, The effect of simple process operation

Active Publication Date: 2015-12-16
SICHUAN YINGLU WEITE PHARMA TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Application number: 200910082470.6, Invention name: Preparation method of Burnet eucalyptus and Burnet eucalyptus saponin I, this method needs to be separated and purified by macroporous resin, the cost is high, the efficiency is low, and it is not conducive to industrial production
Application number: 201210129134.4 Invention name: Separation and purification method of total saponins of Burnet burnet. The loss is large, the steps are cumbersome, and it is not conducive to industrial production

Method used

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  • Total ziyuglycoside extract and preparation method and application thereof
  • Total ziyuglycoside extract and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of embodiment 1 Burnet burnet total saponins extract

[0035] Take 1 kg of Burnet decoction pieces, crush them properly, add 8 times the amount of 90% ethanol to reflux and extract twice, each time for 1.5 hours, filter, combine the two extracts, let stand and let cool, add 10% NaOH solution to adjust the pH to 12 ~14, let it stand overnight, centrifuge to remove the precipitate, and filter the filtrate with suction to obtain the supernatant. Concentrate the supernatant to an appropriate volume under reduced pressure, add an appropriate amount of water until the ethanol concentration is about 20%, adjust the pH to 11-12 with 10% NaOH solution, let it stand for 12 hours, and collect the precipitate by centrifugation; continue to use 10% NaOH solution for the supernatant Adjust the pH of the solution to 12-13, let it stand for 12 hours, and collect the precipitate by centrifugation; combine the precipitates on both sides, depressurize to dryness at ...

Embodiment 2

[0036] The preparation method of embodiment 2 Burnet Burnet total saponins extract

[0037] Take 1kg of Burnet decoction pieces, crush them properly, add 8 times the amount of 90% methanol to reflux and extract twice, each time for 1.5 hours, filter, combine the two extracts, let stand and let cool, add 10% NaOH solution to adjust the pH to 12 ~14, let it stand overnight, centrifuge to remove the precipitate, and filter the filtrate with suction to obtain the supernatant. Concentrate the supernatant to an appropriate volume under reduced pressure, add an appropriate amount of water to reach a methanol concentration of about 20%, adjust the pH to 11-12 with 10% NaOH solution, let it stand for 12 hours, and collect the precipitate by centrifugation; continue to use 10% NaOH solution for the supernatant Adjust the pH of the solution to 12-13, let it stand for 12 hours, and collect the precipitate by centrifugation; combine the precipitates on both sides, depressurize to dryness a...

Embodiment 3

[0038] The preparation method of embodiment 3 Burnet Burnet total saponins extract

[0039] Take 1 kg of Burnet decoction pieces, crush them properly, add 8 times the amount of 90% ethanol to reflux and extract twice, each time for 1.5 hours, filter, combine the two extracts, let stand and let cool, add 10% KOH solution to adjust the pH to 12 ~14, let it stand overnight, centrifuge to remove the precipitate, and filter the filtrate with suction to obtain the supernatant. Concentrate the supernatant to an appropriate volume under reduced pressure, add an appropriate amount of water until the ethanol concentration is about 20%, adjust the pH to 11-12 with 10% KOH solution, let it stand for 12 hours, and collect the precipitate by centrifugation; continue to use 10% KOH for the supernatant Adjust the pH of the solution to 12-13, let it stand for 12 hours, and collect the precipitate by centrifugation; combine the precipitates on both sides, depressurize to dryness at 70°C, reflux...

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Abstract

The invention provides total ziyuglycoside extract and a preparation method and application thereof. The total ziyuglycoside extract has total saponins content up to 98.50%. Compared with existing methods, the preparation method has the advantage that content of total ziyuglycoside in the total ziyuglycoside extract is significantly increased, with activity of rising white blood cells being significantly improved. The preparation method is simple to operate, high in efficiency and low in production cost, and industrial production of the total ziyuglycoside is benefited. The rising white blood cells in the total ziyuglycoside extract prepared by the invention are high in activity, and a new pharmaceutical for the clinical treatment of leukopenia is provided.

Description

technical field [0001] The invention relates to a total saponin extract of Burnet eucalyptus, a preparation method and application thereof, and belongs to the field of medicines. Background technique [0002] Bone marrow suppression often occurs during tumor radiotherapy and chemotherapy, resulting in leukopenia. The decrease in the number of white blood cells will weaken the body's immune ability, and severe infection and bleeding often occur clinically. Therefore, the treatment of leukopenia caused by tumor radiotherapy and chemotherapy needs to start with the protection of bone marrow hematopoietic function. [0003] Burnet has been used as a prescription preparation for the treatment of myelosuppression for more than 20 years. It has the advantages of small dosage, significant curative effect, safety and non-toxicity, wide range of sources, simple preparation process, and low price. Therefore, it is expected to be developed into clinical medicine. An irreplaceable natu...

Claims

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Application Information

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IPC IPC(8): A61K36/739A61P7/00
Inventor 杨世林
Owner SICHUAN YINGLU WEITE PHARMA TECH CO LTD
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