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Nanostrip dopo-hq cyclotriphosphazene derivative and preparation method thereof

A DOPO-HQ, cyclotriphosphazene technology, applied in the field of DOPO-HQ cyclotriphosphazene derivatives and their preparation, achieves the effects of no inflammatory reaction, good biocompatibility, and mild reaction conditions

Inactive Publication Date: 2017-09-12
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are six active chlorine atoms in the structure that can be replaced to produce a variety of cyclotriphosphazene derivatives. There have been some reports on the synthesis and application of cyclotriphosphazene derivatives, but cyclotriphosphazene derivatives are used in biomedicine There are few studies on it, only Sohn et al. have synthesized amphiphilic cyclic triphosphazene derivatives, which are used to include anticancer drugs, improve the targeting of drug delivery, and reduce the physiological toxicity of anticancer drugs

Method used

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  • Nanostrip dopo-hq cyclotriphosphazene derivative and preparation method thereof
  • Nanostrip dopo-hq cyclotriphosphazene derivative and preparation method thereof
  • Nanostrip dopo-hq cyclotriphosphazene derivative and preparation method thereof

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specific Embodiment approach 1

[0022] Specific embodiment one: the preparation method of the nanostrip DOPO-HQ cyclotriphosphazene derivative in this embodiment is carried out according to the following steps:

[0023] In the atmospheric distillation device, add about 50mL of triethylamine, and collect the distillate at 89-90°C for later use.

[0024] Add 1.36g of DOPO-HQ and 80mL of tetrahydrofuran into a 250mL three-necked flask equipped with an ultrasonic mixing device, and ultrasonically dissolve. Measure 2.0 mL of refined triethylamine, add DOPO-HQ in tetrahydrofuran solution, and mix for 5 minutes. Weigh 0.5 g of hexachlorocyclotriphosphazene, add 30 mL of tetrahydrofuran and stir to dissolve, then slowly drop it into the reactor through a constant pressure dropping funnel. After the dropwise addition, continue to react for 5 hours, and a large amount of white solids precipitate out. Most of the tetrahydrofuran solvent was removed by rotary evaporation, the concentrated solution was poured into a 50m...

specific Embodiment approach 2

[0025] Specific embodiment two: the preparation method of the nanostrip DOPO-HQ cyclotriphosphazene derivative in this embodiment is carried out according to the following steps:

[0026] Step 1. Add 4.2mmol dry DOPO-HQ to 100mL tetrahydrofuran, stir until completely dissolved;

[0027] Step 2, then add 0.5mL refined triethylamine (collected 89~90°C distillate after Tianjin Kemiou AR distillation), add dropwise (drop speed 1mL / min) tetrahydrofuran solution of hexachlorocyclotriphosphazene (1mmol hexachloro Cyclotriphosphazene was prepared by adding 20mL of tetrahydrofuran), and then ultrasonically refluxed for 10h under the conditions of ultrasonic frequency of 40HZ, power of 210W, and reaction temperature of 70°C;

[0028] Step 3, then centrifuge (6000r / min, 20min), wash with 30mL acetone and distilled water ultrasonically (210W, 2min), respectively, to obtain (fluorescent nanostrips) DOPO-HQ cyclotriphosphazene derivative;

[0029] The DOPO-HQ cyclotriphosphazene derivative...

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Abstract

The invention discloses a nanometer strip DOPO-HQ cyclotriphosphazene derivative, and relates to a DOPO-HQ cyclotriphosphazene derivative and a preparing method thereof. The general structural formula of the nanometer strip DOPO-HQ cyclotriphosphazene derivative is as follows (see the description), wherein R represents a compound (see the description) and is a fluorescence nanometer strip in morphology, and the partical size is 50-200 nm. The preparing method includes the steps that dry DOPO-HQ is added into tetrahydrofuran and stirred to be dissolved completely; an acid-binding agent is added, a tetrahydrofuran solution of hexachloro cyclotriphosphazene is dripped, and then ultrasonic reflux is carried out for 10-12 h; centrifugation and ultrasonic washing with acetone and distilled water are carried out to obtain the nanometer strip DOPO-HQ cyclotriphosphazene derivative. The derivative serves as a carrier for targeted drug delivery and is capable of achieving targeted medical delivery and fluorescence tracing.

Description

technical field [0001] The invention relates to a DOPO-HQ cyclotriphosphazene derivative and a preparation method thereof. Background technique [0002] Phosphazene polymers are a new class of macromolecular compounds with phosphorus and nitrogen atoms alternately arranged as the main chain structure, and different functional substituent groups are connected to the phosphorus atoms to obtain special properties. Its special structure leads to this These compounds combine stability and activity. Its stability is mainly reflected in the fact that the inorganic main chain of phosphazenes has excellent properties such as water resistance, solvent resistance, oil and chemical resistance, radiation resistance, high and low temperature resistance, flame retardancy, good optical transparency, and high light and heat stability. ; On the other hand, active chlorine atoms are easily substituted to introduce different functional groups, thereby preparing different functional materials. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G79/02C07F9/6593C09K11/06A61K47/34
Inventor 李晓丽马超李志国
Owner NORTHEAST FORESTRY UNIVERSITY
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