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Nanoparticle DOPO-HQ PZHQ and preparation method thereof

A DOPO-HQ and cyclotriphosphazene technology is applied in the field of DOPO-HQ cyclotriphosphazene derivatives and their preparation, and achieves the effects of good biocompatibility, efficient and practical preparation method and high yield

Inactive Publication Date: 2015-12-02
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are six active chlorine atoms in the structure that can be replaced to produce a variety of cyclotriphosphazene derivatives. There have been some reports on the synthesis and application of cyclotriphosphazene derivatives, but cyclotriphosphazene derivatives are used in biomedicine There are few studies on it, only Sohn et al. have synthesized amphiphilic cyclic triphosphazene derivatives, which are used to include anticancer drugs, improve the targeting of drug delivery, and reduce the physiological toxicity of anticancer drugs

Method used

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  • Nanoparticle DOPO-HQ PZHQ and preparation method thereof
  • Nanoparticle DOPO-HQ PZHQ and preparation method thereof
  • Nanoparticle DOPO-HQ PZHQ and preparation method thereof

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specific Embodiment approach 1

[0022] Embodiment 1: Add about 50 mL of triethylamine to an atmospheric distillation device, and collect the distillate at 89-90° C. for later use.

[0023] Add 0.136g of DOPO-HQ and 80mL of acetonitrile into a 250mL three-neck flask equipped with an ultrasonic mixing device, and ultrasonically dissolve. Measure 2.0 mL of refined triethylamine, add it to the acetonitrile solution of DOPO-HQ, and mix for 5 minutes. Weigh 0.05 g of hexachlorocyclotriphosphazene, add 30 mL of acetonitrile and stir to dissolve, then slowly drop it into the reactor through a constant pressure dropping funnel, and continue to react for 5 hours to obtain a white suspension. Most of the acetonitrile solvent was removed by rotary evaporation, the concentrated solution was poured into a 50mL centrifuge tube, centrifuged at 6000r / min for 20 minutes, ultrasonically washed, centrifuged, and dried to obtain 0.12g of the final product with a yield of 81.52%.

specific Embodiment approach 2

[0024] Specific embodiment two: the preparation method of the nano-microsphere DOPO-HQ cyclotriphosphazene derivative in the present embodiment is carried out according to the following steps:

[0025] Step 1. Add 0.42mmol dry DOPO-HQ to 100mL acetonitrile and stir until completely dissolved;

[0026] Step 2, then add 2mL of refined triethylamine (collect 89-90°C distillate after Tianjin Kemiou AR distillation), add dropwise (drop speed 1mL / min) acetonitrile solution of hexachlorocyclotriphosphazene (1mmol hexachlorocyclotriphosphazene Triphosphazene was added to 220mL acetonitrile prepare ), and then the ultrasonic frequency is 40HZ and the power is 150W, and the reaction temperature is 50 ℃ under the condition of ultrasonic reflux for 10h;

[0027] Step 3, then concentrate (80°C), ultrasonically wash with water, and then vacuum-dry (50°C, 12h) to obtain nanosphere DOPO-HQ cyclotriphosphazene derivatives;

[0028] The DOPO-HQ cyclotriphosphazene derivatives (PZHQ) fluoresc...

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Abstract

The invention discloses a nanoparticle DOPO-HQ PZHQ and relates to a DOPO-HQ PZHQ and a preparation method thereof. The structural formula of the nanoparticle DOPO-HQ PZHQ is shown in the description, wherein the structural formula of R is also shown in the description, and R has a microstructure of fluorescent nanoparticle with the particle size of 200-500 nm. The preparation method comprises the following steps: I, adding acetonitrile into dried DOPO-HQ, and stirring until complete dissolution; II, then adding an acid-binding agent, dropwise adding acetonitrile solution of phosphonitrilic chloride trimerl, and performing ultrasonic backflow for 10-12 h; III, concentrating, washing with distilled water in an ultrasonic manner, and performing suction filtration and vacuum drying to obtain the fluorescent nanoparticle DOPO-HQ PZHQ. As a targeted drug delivery carrier, the nanoparticle DOPO-HQ PZHQ can realize the purposes of drug delivery targeting and fluorescent tracer.

Description

technical field [0001] The invention relates to a DOPO-HQ cyclotriphosphazene derivative and a preparation method thereof. Background technique [0002] Phosphazene polymers are a new class of macromolecular compounds with phosphorus and nitrogen atoms alternately arranged as the main chain structure, and different functional substituent groups are connected to the phosphorus atoms to obtain special properties. Its special structure leads to this These compounds combine stability and activity. Its stability is mainly reflected in the fact that the inorganic main chain of phosphazenes has excellent properties such as water resistance, solvent resistance, oil and chemical resistance, radiation resistance, high and low temperature resistance, flame retardancy, good optical transparency, and high light and heat stability. ; On the other hand, active chlorine atoms are easily substituted to introduce different functional groups, thereby preparing different functional materials. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/6593
Inventor 李晓丽马超李志国
Owner NORTHEAST FORESTRY UNIVERSITY
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