Hexaminoacid ester phenoxyl cyclotriphosphazene, its fluorescent nano-microsphere and preparation method thereof

A technology of ester phenoxy cyclotriphosphazene and carboxyphenoxy cyclotriphosphazene is applied in the field of cyclotriphosphazene and its fluorescent nano-microspheres and preparation, and achieves the effects of simple process, high yield and stable structure
CN102408445AInactive Publication Date: 2012-04-11NORTHEAST FORESTRY UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NORTHEAST FORESTRY UNIVERSITY
Publication Date
2012-04-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

Relating to cyclotriphosphazene and its fluorescent nano-microsphere as well as a preparation method, the invention provides hexaminoacid ester phenoxyl cyclotriphosphazene, its fluorescent nano-microsphere and a preparation method thereof. Hexaminoacid ester phenoxyl cyclotriphosphazene has a general structural formula as shown in the picture, wherein, M is amino acid x ester. And hexaminoacid ester phenoxyl cyclotriphosphazene is prepared by first reacting 6 pairs of carboxyphenoxyl cyclotriphosphazene with thionyl chloride, and then adding amino-acid ester hydrochloride and an acid binding agent for reaction. Composed of hexaminoacid ester phenoxyl cyclotriphosphazene, the fluorescent nano-microsphere is prepared by the steps of: dissolving hexaminoacid ester phenoxyl cyclotriphosphazene in an organic solvent, then adding distilled water dropwisely, and pouring water, then conducting dialysis and freeze-drying, thus obtaining the fluorescent nano-microsphere. Hexaminoacid ester phenoxyl cyclotriphosphazene has stable structure, good biocompatibility, easy degradation, degradation product free of toxicity and inflammatory response, and its preparation method has a yield up to over 80%, mild reaction conditions, and a simple process, thus boasting very good industrial application prospects. Under ultraviolet excitation, the fluorescent nano-microsphere can generate a fluorescence phenomenon, and can serve as a carrier of targeting drug delivery.
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Description

technical field

[0001] The invention relates to a cyclotriphosphazene, fluorescent nanometer microspheres and a preparation method thereof. Background technique

[0002] Phosphazene polymers are a new class of macromolecular compounds with phosphorus and nitrogen atoms alternately arranged as the main chain structure, and different functional substituent groups are connected to the phosphorus atoms to obtain special properties. Its special structure leads to this These compounds combine stability and activity. Its stability is mainly reflected in the fact that the inorganic main chain of phosphazenes has excellent properties such as water resistance, solvent resistance, oil and chemical resistance, radiation resistance, high and low temperature resistance, flame retardancy, good optical transparency, and high light and heat stability. ; On the other hand, active chlorine atoms are easily substituted to introduce different functional groups, thereby preparing different funct...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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