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PET/CT macroscopical digital information and pathological microscopic information matching method

A technology of digital information and information matching, applied in image data processing, instrumentation, computing, etc., can solve the problems of limiting the development of PET/CT and the inability to detect endogenous tumor markers by immunohistochemistry

Inactive Publication Date: 2015-12-23
胡漫
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  • Claims
  • Application Information

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Problems solved by technology

At present, large slices are limited to HE staining, and immunohistochemical detection of endogenous tumor markers cannot be performed. Therefore, how to match the biological function information of human tumors detected by PET / CT with histological pathological diagnosis information It is the difficulty of current research, which limits the development of PET / CT in the diagnosis and treatment of malignant tumors

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  • PET/CT macroscopical digital information and pathological microscopic information matching method
  • PET/CT macroscopical digital information and pathological microscopic information matching method

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Embodiment 1

[0029] A method for matching PET / CT macroscopic digital information with pathological microscopic information, comprising the following steps:

[0030] Step 1: As shown in Figure 1(a) and Figure 1(b), restore the postoperative specimen to the in vivo state, and then immerse it in formalin for 24 hours; The resected lung tissue is marked with X, Y, and Z in the natural state of the body, and the lung tissue is isolated to form a specimen, and the specimen is positioned according to the three-dimensional direction in the body, and the specimen is restored to the in vivo state;

[0031] Step 2: If Figure 2(a)-Figure 2(c) As shown, review the preoperative PET / CT image, and the cross-section is formed between the highest level of tracer uptake in the PET / CT image and the carina (in this embodiment, it is the lesion in the lung, so the carina is selected; if it is For intracerebral lesion scanning, select the blood vessel indicated by the specimen), cut the specimen from the middle...

Embodiment 2

[0039] A method for matching PET / CT macroscopic digital information with pathological microscopic information, comprising the following steps:

[0040] Step 1: As shown in Figure 1(a) and Figure 1(b), restore the postoperative specimen to the in vivo state, and then immerse it in formalin for 16 hours; The resected lung tissue is marked with X, Y, and Z in the natural state of the body, and the lung tissue is isolated to form a specimen, and the specimen is positioned according to the three-dimensional direction in the body, and the specimen is restored to the in vivo state;

[0041] Step 2: If Figure 2(a)-Figure 2(c) As shown, review the preoperative PET / CT image, and the cross-section is formed between the highest level of tracer uptake in the PET / CT image and the carina (in this embodiment, it is the lesion in the lung, so the carina is selected; if it is For intracerebral lesion scanning, select the blood vessel indicated by the specimen), cut the specimen from the middle...

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Abstract

The invention provides a PET / CT (Positron Emission Tomography / Computed Tomography) macroscopical digital information and pathological microscopic information matching method. A postoperative sample is reduced into an in-vivo state and is soaked into formalin; a cross section is formed between the tracer highest-ingestion layer surface in a PET / CT image and an adjacent anatomic landmark; the sample is cut apart from the middle in the cross section direction, and is soaked into the formalin; HE (Hematoxylin-Eosin) staining pathological sections are manufactured; a paraffin block region of an immune tissue chemical staining region in each HE staining pathological section is determined; the selected paraffin block region is fixed, and the paraffin section cutting is performed; and the parameter of the tracer high-ingestion layer surface in each layer of PET / CT image and the corresponding layer immunohistochemistry expression are analyzed. The PET / CT image information and immunohistochemistry information matching accuracy is improved; a tracer high-ingestion region and a histology region are accurately registered; and after the matching, the accuracy of the PET / CT on the detection of the in-vivo oncobiology information can be verified.

Description

technical field [0001] The invention relates to the technical field of functional image analysis, in particular to a method for matching PET / CT macroscopic digital information with pathological microscopic information. Background technique [0002] PET / CT (positronemissiontomography / computedtomography) is called positron emission tomography / X-ray computed tomography, which is a combination of PET (functional metabolic imaging) and CT (anatomical structure imaging) A new type of imaging equipment that is organically combined. It injects a small amount of positron nuclide tracers into the human body, and then uses a special in vitro detector (PET) to detect the distribution of these positron nuclide in various organs of the human body The computer tomography method is used to display the physiological and metabolic functions of the main organs of the human body, and at the same time, CT technology is used to accurately locate the distribution of these nuclides, so that this ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/03G06T7/00G06T7/30
Inventor 胡漫李新科孙菊杰卢洁李丽范秉杰
Owner 胡漫
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