Pyridine oxadiazole complex capable of catalyzing DHPMs (Dihydropyrimidinones)
A technology of dihydropyrimidinones and complexes, which can be used in organic compound/hydride/coordination complex catalysts, cobalt organic compounds, organic chemistry, etc., can solve the problems of unfriendly environment, long reaction time and high reaction temperature , to achieve the effect of shortening the reaction time, reducing the dosage, and simplifying the experimental operation
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Embodiment 1
[0019] Embodiment 1, product 1 Synthesis
[0020] 0.035g of p-toluenesulfonic acid (0.2mmol), 0.008g of sodium hydroxide (0.2mmol), 0.045g BPO (0.2mmol) and 0.029g of cobalt nitrate (0.1mmol) were dissolved in a mixed solution of water (2mL) and methanol (3mL). Transfer the reaction mixture to a reaction kettle and heat it at 120 degrees for 5 hours, then slowly lower it to room temperature at a rate of 5 degrees per hour, filter, stand still, and precipitate a red target product 1 and determine its crystal structure. in BPO The structural formula is as figure 1 ; the resulting product 1 The molecular structure was determined by single crystal X-ray diffraction analysis as figure 2 .
Embodiment 2
[0021] Embodiment two, the method for catalytic synthesis of dihydropyrimidinone compounds
[0022] Get 0.02mmol of product 1 as a catalyst and join in the mixture of 1mmol benzaldehyde, 2mmol ethyl acetoacetate and 1.5mmol urea, heat in an oil bath at 80 degrees Celsius for 2 hours to obtain a colorless product, and finally wash with water and methanol purification to obtain the target product. Finally, different aldehydes were selected to catalyze a series of dihydropyrimidinones and their derivatives under the same conditions. Among them, the catalytic results are as image 3 .
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