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Medicine slow-release nanoparticle wrapping magnetosomes of magnetotactic bacteria and preparation method of medicine slow-release nanoparticle

A technology of magnetotactic bacteria and nano-microspheres, applied in the field of biomedicine, can solve problems such as poor water solubility, poor tolerance, and affecting clinical application of drugs

Inactive Publication Date: 2015-12-30
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, most clinical drugs have defects such as poor tolerance, strong cytotoxic side effects, poor oral absorption, poor water solubility, and short biological half-life, which affect the clinical application of drugs.

Method used

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  • Medicine slow-release nanoparticle wrapping magnetosomes of magnetotactic bacteria and preparation method of medicine slow-release nanoparticle
  • Medicine slow-release nanoparticle wrapping magnetosomes of magnetotactic bacteria and preparation method of medicine slow-release nanoparticle
  • Medicine slow-release nanoparticle wrapping magnetosomes of magnetotactic bacteria and preparation method of medicine slow-release nanoparticle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 A drug sustained-release nanosphere embedded with magnetotactic bacterial magnetosomes

[0029] The composition of the sustained-release nanometer microsphere is: 1 part of magnetosome of magnetotactic bacteria, 1 part of chitosan, 1 part of methyl cellulose and 10 parts of camptothecin.

[0030] The preparation of slow-release nanospheres embedded with magnetotactic bacterial magnetosomes is achieved by the following methods:

[0031] (1) Collect magnetotactic bacteria after culturing Magnetospiri-llumsp.AMB-1, break the wall with 500W ultrasound for 1 hour, release magnetosomes, and apply an external magnetic field to absorb and recover magnetosomes.

[0032] (2) Rinse the magnetosomes with physiological saline for 3 times, mix chitosan, methylcellulose, and camptothecin with a molecular weight of 10KDa and a deacetylation degree of 50% according to the above ratio, and prepare nano Microspheres; spray drying conditions are: inlet air temperature 80°C, outl...

Embodiment 2

[0034] Example 2 A drug slow-release nanosphere embedded with magnetotactic bacterial magnetosomes

[0035] The composition of the sustained-release nano microspheres is: 9 parts of magnetosomes of magnetotactic bacteria, 20 parts of chitosan, 4 parts of hydroxypropyl cellulose, and 10 parts of adriamycin.

[0036] The preparation of slow-release nanospheres embedded with magnetotactic bacterial magnetosomes is achieved by the following methods:

[0037] (1) Collect the magnetotactic bacteria after culturing M. gryphiswaldenseMSR-1, break the wall with 600W ultrasound for 0.5h, release the magnetosomes, and apply an external magnetic field to absorb and recover the magnetosomes.

[0038] (2) Rinse the magnetosomes with physiological saline for 5 times, mix chitosan, hydroxypropyl cellulose, and doxorubicin with a molecular weight of 100KDa and a degree of deacetylation of 80% according to the above ratio, and prepare by spray drying Nano microspheres; spray drying conditions ...

Embodiment 3

[0040] Example 3 A drug slow-release nanosphere embedded with magnetotactic bacterial magnetosomes

[0041] The composition of the sustained-release nano microspheres is: 10 parts of magnetosomes of magnetotactic bacteria, 5 parts of chitosan, 5 parts of pectin and 10 parts of vincristine.

[0042] The preparation of slow-release nanospheres embedded with magnetotactic bacterial magnetosomes is achieved by the following methods:

[0043] (1) Collect the magnetotactic bacteria after culturing M. magnetotacticumMS-1, break the wall with 300W ultrasound for 2 hours, release the magnetosomes, and apply an external magnetic field to absorb and recover the magnetosomes.

[0044] (2) Rinse the magnetosomes with normal saline for 3 times, mix chitosan, pectin, and vincristine with a molecular weight of 2000KDa and a degree of deacetylation of 90% according to the above ratio, and prepare nanospheres by spray drying ; Spray drying conditions are: inlet air temperature 180°C, outlet te...

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Abstract

The invention relates to a medicine slow-release nanoparticle wrapping magnetosomes of magnetotactic bacteria and a preparation method of the medicine slow-release nanoparticle. The medicine slow-release nanoparticle comprises the magnetosomes of magnetotactic bacteria, chitosan, pharmaceutic adjuvant and medicine components. The preparation method includes the steps of collecting the magnetosomes of magnetotactic bacteria, mixing the materials, conducting spray drying to obtain the nanoparticle, wherein the grain size of the nanoparticle ranges from 100 nanometers to 50 micrometers. According to different treatment aims, the nanoparticle can serve as an oral slow-release formulation, can be used as a slow-release formulation for preparing targeted medicine as well, and can be widely applied to the field of biological medicine.

Description

technical field [0001] The invention relates to a drug slow-release nano-microsphere, in particular to a drug slow-release nano-microsphere embedded with a magnetosome of magnetotactic bacteria, belonging to the field of biomedicine. Background technique [0002] At present, most clinical drugs have defects such as poor tolerance, strong cytotoxic side effects, poor oral absorption, poor water solubility, and short biological half-life, which affect the clinical application of drugs. In order to achieve the purpose of improving the performance of drugs, technologies such as time-selective pulse release, drug precursor design, transdermal drug delivery and nano-microspheres have been developed at home and abroad. Among them, nano-microsphere sustained-release technology has the advantages of specific tropism to target organs, long duration of drug release, and improved bioavailability. [0003] As a drug delivery platform, nanospheres can improve the efficacy of active pharm...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/46A61K31/4745A61K31/704A61K31/475A61K31/337A61K31/7076A61P35/00
Inventor 李晓岩赵敏赵庆生
Owner NORTHEAST FORESTRY UNIVERSITY
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