Medicine slow-release nanoparticle wrapping magnetosomes of magnetotactic bacteria and preparation method of medicine slow-release nanoparticle

A technology of magnetotactic bacteria and nano-microspheres, applied in the field of biomedicine, can solve problems such as poor water solubility, poor tolerance, and affecting clinical application of drugs
CN105193733AInactive Publication Date: 2015-12-30NORTHEAST FORESTRY UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
NORTHEAST FORESTRY UNIVERSITY
Publication Date
2015-12-30
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a medicine slow-release nanoparticle wrapping magnetosomes of magnetotactic bacteria and a preparation method of the medicine slow-release nanoparticle. The medicine slow-release nanoparticle comprises the magnetosomes of magnetotactic bacteria, chitosan, pharmaceutic adjuvant and medicine components. The preparation method includes the steps of collecting the magnetosomes of magnetotactic bacteria, mixing the materials, conducting spray drying to obtain the nanoparticle, wherein the grain size of the nanoparticle ranges from 100 nanometers to 50 micrometers. According to different treatment aims, the nanoparticle can serve as an oral slow-release formulation, can be used as a slow-release formulation for preparing targeted medicine as well, and can be widely applied to the field of biological medicine.
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Description

technical field

[0001] The invention relates to a drug slow-release nano-microsphere, in particular to a drug slow-release nano-microsphere embedded with a magnetosome of magnetotactic bacteria, belonging to the field of biomedicine. Background technique

[0002] At present, most clinical drugs have defects such as poor tolerance, strong cytotoxic side effects, poor oral absorption, poor water solubility, and short biological half-life, which affect the clinical application of drugs. In order to achieve the purpose of improving the performance of drugs, technologies such as time-selective pulse release, drug precursor design, transdermal drug delivery and nano-microspheres have been developed at home and abroad. Among them, nano-microsphere sustained-release technology has the advantages of specific tropism to target organs, long duration of drug release, and improved bioavailability.

[0003] As a drug delivery platform, nanospheres can improve the efficacy of active pharm...

Claims

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