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Cefaclor tablet composition as well as preparation method and application thereof

A technology of cefaclor tablet and cefaclor, applied in the field of pharmaceutical composition of cefaclor tablet

Inactive Publication Date: 2015-12-30
HAIKOU PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cefaclor has been used for more than 20 years, but its antibacterial spectrum and antibacterial activity against Gram-positive and negative bacteria have not declined

Method used

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  • Cefaclor tablet composition as well as preparation method and application thereof
  • Cefaclor tablet composition as well as preparation method and application thereof
  • Cefaclor tablet composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 The present invention adopts dry granulation to prepare the technique of cefaclor tablet

[0032] (1) Preparation process: take cefaclor raw material and pass through 80-mesh sieve, and pass through 80-mesh sieve for auxiliary materials except flow aid respectively, and mix evenly in a CH50V mixer with a rotating speed of 25-30 rpm and a mixing time of about 30 Minutes, the mixed material is granulated with GL-5B dry granulator, feeding speed: 55-65rpm, 250-300g / min, pressing wheel speed: 5-7rpm, pressing wheel spacing: 0.1-0.3mm, granulation speed: 298rpm, the qualified granules are controlled at 20-40 meshes, the angle of repose of the granules is measured to be less than 30°, the flow aid of the prescribed amount is added, placed in a ZP35D tablet press for tableting, the speed of the tablet press is adjusted to 13 rpm, and the tablet pressure is controlled to 7~10kg. Film coat Opadry, the film coating premix, with purified water.

[0033] (2) The fo...

Embodiment 2

[0037] (1) preparation process is with embodiment 1;

[0038] (2) The formula of cefaclor tablet composition is shown in Table 2:

[0039] Table 2, cefaclor tablet formula 2

[0040] component name

Embodiment 3

[0042] (1) preparation process is with embodiment 1;

[0043] (2) The formula of cefaclor tablet composition is shown in Table 3:

[0044] Table 3, cefaclor tablet formula 3

[0045] component name

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PUM

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Abstract

The invention provides cefaclor tablet composition. The composition is prepared through dry granulation, during granulation, the liquid pressure is 2-4 MPa, the extrusion speed is 15-20 r / min, the feeding speed is 200-300 g / min, the cake pressing thickness is 0.3-2 mm, and water or ethyl alcohol is not required to be added. The invention further provides a preparation method of the cefaclor tablet composition and an application of the cefaclor tablet composition to preparation of drugs having the antibacterial effect.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical composition of cefaclor tablets, a preparation method and application thereof. Background technique [0002] Cefaclor is the second-generation oral cephalosporin created by Eli Lilly and Company of the United States. It was first listed in 1982 under the trade name "Xickrao". In 1993, its patent expired. In addition to the Lilly Company of the United States and the Shionogi Pharmaceutical Company of Japan, the suppliers also included ACSDobfar Company of Italy and Ranbaxy Company of India. [0003] Cefaclor is a β-lactam antibiotic, chemical name: (6R,7R)-7-[(R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-5-sulfur Hetero-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate, molecular formula C 15 h 14 ClN 3 o 4 S·H 2 O, molecular weight is 385.82, its chemical structure formula is as follows: [0004] [0005] Cefaclor is a white to light ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/26A61K47/36A61K47/32A61K31/545A61P31/04
CPCY02A50/30
Inventor 张志兰王彬潘丽
Owner HAIKOU PHARMA FACTORY
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