Medicated bath granules of artemisinin or derivatives of artemisinin and application of medicated bath granules

A derivative, artemisinin technology, applied in the field of medicated bath granules, can solve problems such as unsuitability for use

Active Publication Date: 2016-01-06
海南中和美业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Preparation of artemisinin or its derivatives into medicated baths is not reported in the prior art. The inventors found in the course of research that directly adding artemisinin and its derivatives to the bath will cause emulsion or sediment, and because Artemisia annua Artemisinin or its ...

Method used

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  • Medicated bath granules of artemisinin or derivatives of artemisinin and application of medicated bath granules
  • Medicated bath granules of artemisinin or derivatives of artemisinin and application of medicated bath granules
  • Medicated bath granules of artemisinin or derivatives of artemisinin and application of medicated bath granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] The preparation of embodiment 1 artemisinin medicinal bath granule

[0121] Prescription 1:

[0122] Artemisinin 200g

[0123] Sodium bicarbonate 3750g

[0124] Sodium sulfate 2550g

[0125] --------------------------------------

[0126] Make 1000 bags

[0127] Preparation method: In a D-level clean area that complies with the provisions of the Good Manufacturing Practice (GMP), the prescribed quantities of artemisinin, sodium bicarbonate, and sodium sulfate are respectively pulverized with a pulverizer, passed through a 60-mesh sieve, and then added with V -type mixer, mixed in mixer for 10 minutes, and the material after total mixing was bagged on the granule distributing machine, and the dispensing amount was 6.5g, made 1000 bags, promptly got artemisinin medicated bath granule (I).

[0128] Prescription 2:

[0129] Artemisinin 6250g

[0130] Sodium bicarbonate 10000g

[0131] Sodium sulfate 10000g

[0132] --------------------------------------

[0133] M...

Embodiment 2

[0142] The preparation of embodiment 2 dihydroartemisinin medicated bath granule

[0143] Prescription 4:

[0144] Dihydroartemisinin 80g

[0145] Sodium bicarbonate 3750g

[0146] Sodium sulfate 2550g

[0147] --------------------------------------

[0148] Make 1000 bags

[0149] Preparation method: In a D-level clean area that complies with the provisions of the Good Manufacturing Practice (GMP), the prescription quantities of dihydroartemisinin, sodium bicarbonate, and sodium sulfate are respectively pulverized with a pulverizer, passed through a 60-mesh sieve, and sequentially Add V-type mixer, mix in mixer for 10 minutes, the material after total mixing is bagged on the particle packing machine, and the subpackage is 7.1g, makes 1000 bags, obtains dihydroartemisinin medicated bath granule ( I).

[0150] Prescription 5:

[0151] Dihydroartemisinin 2000g

[0152] Sodium bicarbonate 8750g

[0153] Sodium sulfate 4250g

[0154] -------------------------------------...

Embodiment 3

[0164] The preparation of embodiment 3 artesunate medicated bath granules

[0165] Prescription 7:

[0166]Artesunate 300g

[0167] Sodium bicarbonate 3750g

[0168] Sodium sulfate 2550g

[0169] --------------------------------------

[0170] Make 1000 bags

[0171] Preparation method: In a D-level clean area that complies with the provisions of the Good Manufacturing Practice (GMP), the prescribed quantities of artesunate, sodium bicarbonate, and sodium sulfate are respectively pulverized with a pulverizer, passed through a 60-mesh sieve, and added in sequence V-type mixer, mixed in the mixer for 10 minutes, the material after the total mixing was bagged on the particle packing machine, and the sub-package was 6.6g, and 1000 bags were made to obtain the artesunate medicated bath granule (I) .

[0172] Prescription 8:

[0173] Artesunate 10000g

[0174] Sodium bicarbonate 10000g

[0175] Sodium sulfate 10000g

[0176] --------------------------------------

[0177]...

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Abstract

The invention relates to medicated bath granules of artemisinin or derivatives of the artemisinin and application of the medicated bath granules. The medicated bath granules take the artemisinin or the derivatives of the artemisinin as main active pharmaceutical ingredients, and comprise the following components in weight proportion: 0.1 to 20g of artemisinin or the derivatives of the artemisinin, 1 to 40g of sodium bicarbonate and 1 to 40g of sodium sulfate; the derivatives of the artemisinin are selected from dihydroartemisinin, artesunate and artemether.

Description

technical field [0001] The invention relates to a medicated bath liquid, in particular to a medicated bath granule prepared from artemisinin or its derivatives and its application. Background technique [0002] Artemisinin is an effective anti-malarial monomer isolated and identified from the taxonomic Artemisia annua (Chinese medicine Artemisia annua) by Chinese scientists in the 1970s. Its structural formula, molecular formula and molecular weight are: [0003] [0004] With the in-depth research on artemisinin, Chinese scientists have developed more active derivatives of artemisinin, such as dihydroartemisinin, artesunate, artemether ( Artemether) and so on. [0005] The structural formula, molecular formula and molecular weight of dihydroartemisinin are as follows: [0006] [0007] The structural formula, molecular formula and molecular weight of artesunate are as follows: [0008] [0009] The structural formula, molecular formula and molecular weight of ar...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/14A61K31/357A61K47/04A61P17/00A61P31/10A61P17/04A61P37/02A61P19/02A61P29/00A61P17/06
Inventor 崔学云杨平
Owner 海南中和美业科技有限公司
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