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Vilazodone orally disintegrating tablet and preparation method thereof

A technology for oral disintegrating tablets and disintegrating agents, which can be applied in the field of medicine and can solve problems such as patent blanks

Inactive Publication Date: 2016-01-06
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are few domestic patents related to vilazodone preparations, and there are temporarily no patents related to immediate-release solid oral preparations or orally disintegrating tablets

Method used

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  • Vilazodone orally disintegrating tablet and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of Vilazodone Orally Disintegrating Tablets (10mg)

[0032] Tablet composition Weight ratio (%) Vilazodone 10 Mannitol 40 microcrystalline cellulose 31.5 Crospovidone 8 Croscarmellose Sodium 8 Acesulfame K 1 silica 1 Magnesium stearate 0.5

[0033] Preparation Process:

[0034] (1) Crushing the vilazodone raw material through a 100-mesh sieve;

[0035] (2) Mix the pulverized raw materials with the prescribed amount of mannitol, microcrystalline cellulose, crospovidone, croscarmellose sodium, and acesulfame potassium;

[0036] (3) Add silicon dioxide and magnesium stearate to the above mixture, mix well and press into tablets with a weight of 100mg and a hardness of 30-40N.

Embodiment 2

[0037] Example 2 Preparation of Vilazodone Orally Disintegrating Tablets (20mg)

[0038] Tablet composition Weight ratio (%) Vilazodone 20 Mannitol 40 microcrystalline cellulose 30.5 Crospovidone 8 Croscarmellose Sodium 8 Acesulfame K 2 silica 1 Magnesium stearate 0.5

[0039] Preparation Process:

[0040] (1) Crushing the vilazodone raw material through a 100-mesh sieve;

[0041] (2) Mix the pulverized raw materials with the prescribed amount of mannitol, microcrystalline cellulose, crospovidone, croscarmellose sodium, and acesulfame potassium;

[0042] (3) Add silicon dioxide and magnesium stearate to the above mixture, mix well and press into tablets with a tablet weight of 110mg and a hardness of 30-40N.

Embodiment 3

[0043] Example 3 Preparation of Vilazodone Orally Disintegrating Tablets (10mg)

[0044] Tablet composition Weight ratio (%) Vilazodone 10 Woodnitol 42 microcrystalline cellulose 31 Crospovidone 6 Croscarmellose Sodium 8 Acesulfame K 1 aspartame 0.5 silica 1 Magnesium stearate 0.5

[0045] Preparation Process:

[0046] (1) Crushing the vilazodone raw material through a 100-mesh sieve;

[0047] (2) Add and mix the pulverized raw materials with the prescribed amount of woodnitol, microcrystalline cellulose, crospovidone, croscarmellose sodium, acesulfame potassium, and aspartame ;

[0048] (3) Add silicon dioxide and magnesium stearate to the above mixture, mix well and press into tablets with a weight of 100mg and a hardness of 30-40N.

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Abstract

The invention discloses a vilazodone orally disintegrating tablet which has good taste, does not need water for administration, is capable of quickly disintegrating after entering the mouth, suitable for patients, having trouble in swallowing, like old people and psychiatric patients to take and also suitable for administration under conditions that water is difficult to get during travelling and wartime. an indication of the vilazodone orally disintegrating tablet is major depression disorder of adults, and administration compliance of the patients can be improved due to good taste and a simple and quick administration mode. In addition, the invention further discloses a preparation method of the vilazodone orally disintegrating tablet. The preparation method is simple in process and low in cost. The orally disintegrating tablet prepared by the method is quick to disintegrate and act, so that administration discomfort of the patients is reduced.

Description

technical field [0001] The invention relates to an orally disintegrating tablet of an antidepressant psychotropic drug and a preparation method thereof, in particular to an orally disintegrating tablet of vilazodone and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Depression, also known as depressive disorder, is the main type of mood disorder with significant and persistent low mood as the main clinical feature. It can be seen clinically that the mood is not commensurate with the situation. The depression of mood can range from gloomy to distraught, low self-esteem and depression, even pessimistic world-weariness, and there may be suicide attempts or behaviors; even stupor; some cases have obvious anxiety and motor agitation; In severe cases, psychotic symptoms such as hallucinations and delusions may appear. Each attack lasts for at least 2 weeks, or even several years in the elderly. Most cases have a tendency ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/496A61K47/38A61P25/24
Inventor 姚丽华张庭
Owner AVENTIS PHARMA HAINAN
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