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Application of Sphenostylisins C in preparation of drugs used for treating rhinitis

A technology for medicine and rhinitis, which is applied in the application field of Sphenostylisins C in the preparation of medicine for treating rhinitis, and can solve the problems of ineffectiveness and poor curative effect of rhinitis.

Inactive Publication Date: 2016-02-03
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used in the treatment of rhinitis. These drugs have poor or ineffective effects on chronicity and recurrent rhinitis

Method used

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  • Application of Sphenostylisins C in preparation of drugs used for treating rhinitis
  • Application of Sphenostylisins C in preparation of drugs used for treating rhinitis
  • Application of Sphenostylisins C in preparation of drugs used for treating rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound SphenostylisinsC tablet involved in the present invention:

[0013] Get 20 grams of compound Sphenostylisins C, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound SphenostylisinsC capsules involved in the present invention:

[0015] Get 20 grams of compound Sphenostylisins C, add conventional adjuvants for preparing capsules such as 180 grams of starch, mix well, and make 1000 capsules.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1, the influence of Sphenostylisins C of the present invention on ovalbumin-induced allergic rhinitis in rats

[0018] Male SD rats, weighing 180-220 g, were intraperitoneally injected with 1 mg of ovalbumin and 10 mg of aluminum hydroxide gel, and then injected once every other day, a total of 7 times. From the 14th day, 10ul of 1mg / ml ovalbumin physiological saline solution was instilled into the nasal cavities of both sides of the rat every day, 7 times in total. Immediately after the last infusion, observe the number of times the rats sneeze and wipe their noses within 30 minutes, and the test drug is orally administered 1 hour before the last infusion of ovalbumin.

[0019] Table 1 The influence of SphenostylisinsC of the present invention on ovalbumin-induced allergic rhinitis in rats (x ± SD)

[0020]

[0021] Compared with the control group, **P<0.01*P<0.05

[0022] It can be seen from Table 1 that Sphenostylisins C (10, 20 mg / kg) signi...

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Abstract

The invention provides Sphenostylisins C used for treating immunity inflammation. The Sphenostylisins C is applicable to preparation of immunity inflammation drugs, especially preparation of drugs used for treating rhinitis. In contrast to terfenadine and diclofenac sodium, the Sphenostylisins C has definite curative effect. The application of the Sphenostylisins C in preparation of drugs used for treating rhinitis is disclosed for the first time; since the skeleton type of the Sphenostylisins C is a brand new skeleton type and good activity of the Sphenostylisins C in treatment of rhinitis is unexpected, possibility of inspiration by any other compound does not exist and the Sphenostylisins C has protruding substantive distinguishing features; meanwhile, substantial progress is made as the Sphenostylisins C is applied to prevention and treatment of rhinitis.

Description

technical field [0001] The present invention relates to the new application of compound Sphenostylisins C, in particular to the application of Sphenostylisins C in the preparation of medicine for treating rhinitis. Background technique [0002] Rhinitis is a common and frequently-occurring disease in clinical practice. The occurrence of rhinitis is mainly related to allergic reactions and belongs to the category of immune inflammation. At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used for the treatment of rhinitis, and these drugs have poor or ineffective effects on chronicity and recurrent rhinitis. Therefore, small molecular compounds with clear components, quality control, safety and high efficiency have potential value in the development of drugs for rhinitis treatment. [0003] The compound Sphenostylisins C involved in the present invention is a new compound published in 2013 (LiJ, et al., Sphenos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P11/02
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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