Application of Tianmu Qionghua Alcoholic Extract in the Preparation of Drugs for Treating Atherosclerotic Diseases
A technique for atherosclerosis and tianmu agarol is applied in the application field of ethanol extract of tianmu agarwood in the preparation of medicines for treating atherosclerotic diseases, so as to achieve good treatment of atherosclerotic diseases, less toxic and side effects, and better treatment of atherosclerosis. Simple preparation method
Inactive Publication Date: 2019-01-08
TAISHAN MEDICAL UNIV
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[0005] The purpose of the present invention is to provide a new application of traditional Chinese medicine Tianmuqionghua ethanol extract in the preparation of drugs for the treatment of atherosclerosis in view of the lack of efficient and safe drugs for atherosclerosis.
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[0017] 1. Materials and methods
[0018] (1) Preparation of Alcoholic Extract of Tianmu Qionghua
[0019] The fruit of Tianmu Qionghua is collected from Mount Tai and identified by Professor Li Tongde, a senior expert in traditional Chinese medicine at Taishan Medical College. The fruit of Tianmu Qionghua was dried at room temperature and ground into a 40-mesh coarse powder, and 500g of the powder was extracted in 95% ethanol (M:V=1:10). The alcohol extract is filtered and concentrated into extract (3.49g crude drug / g), then the extract is prepared into 2.5 g crude drug / ml, 5.0g crude drug / ml, 10.0g crude drug / ml with 5% sodium carboxymethylcellulose ml, stored at 4°C for later use.
[0020] (2) Grouping and handling of animals
[0021] 40 male apoE - / - Mice (20±2g, 7 weeks old) were purchased from Beijing Huafukang Biotechnology Co., Ltd. [permit number: SCYK (Beijing) 2014-0004], and were randomly divided into 5 groups after adaptive feeding for 1 week:
[0022] Model...
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The invention discloses application of an alcohol extract of viburnum sargentii koehne to preparation of medicines for treating AS (atherosclerosis) diseases. By taking C57BL / 6J mice as blank control and taking a simvastatin medicated group as positive control, observation of influences of the viburnum sargentii koehne on AS and exploration of corresponding mechanisms are carried out after a high fat diet-induced apoE<- / -> mouse AS model is intragastrically given with the alcohol extract of the viburnum sargentii koehne for 12 weeks. According to results, the alcohol extract of the viburnum sargentii koehne evidently lowers the level of lipids in serum, inhibits oxidative stress and inflammatory reaction, decelerates formation of atheromatous plaques and lipid accumulation on arterial walls of the high fat diet-induced apoE<- / -> mouse and inhibits AS occurrence and development. By application of the alcohol extract of the viburnum sargentii koehne to preparation of the medicines for treating the AS diseases, not only is a novel usage of the alcohol extract of the viburnum sargentii koehne is developed, but also a novel approach of AS treatment is provided.
Description
technical field [0001] The invention relates to the field of application of Tianmu Qionghua, in particular to the application of an ethanol extract of Tianmu Qionghua in the preparation of medicines for treating atherosclerotic diseases. Background technique [0002] Atherosclerosis (AS) is a common and frequently-occurring disease that seriously endangers human health. The formation and rupture of vulnerable plaques are the main cause of acute clinical symptoms in the late stages of AS. A large number of epidemiological investigations and experimental studies have shown that hyperlipidemia, smoking, diabetes, hypertension, and gender differences are all risk factors related to the occurrence of AS. Richard et al. believe that hyperlipidemia (HLP) is the direct cause of AS. Causes and primary risk factors. Among them, the level of serum cholesterol, especially low-density lipoprotein cholesterol (LDL-C) was positively correlated with the occurrence of AS. Berliner et al fo...
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IPC IPC(8): A61K36/35A61P9/10
Inventor 张颖秦树存姚树桐司艳红
Owner TAISHAN MEDICAL UNIV